... the filopodia structure through controlling actin nucleation effectors mDia1 and mDia2, and these signalling pathways are distinct with the canonical Cdc42/WASP/Arp2/3 filopodia formation pathway, increasing the complexity and specificity of actin cytoskeleton regulation. filopodium lymphocyte morphology...

...-specific chemotaxis regulator (ECSCR) filopodium Robo4 Angiogenesis is the development of new blood vessels from existing vasculature [ 1 ]. This process is fundamental for normal development and healing, but it also occurs in over 70 different disease states, including diabetic retinopathy...

... that is significant to our understanding of cardiovascular disease. 1 To whom correspondence should be addressed (email a.poole@bris.ac.uk ). 7 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 conventional protein kinase C (cPKC) filopodium mouse model platelet...

... of the Ena/VASP family [ 3 , 17 ], but their precise functions and interactions with other proteins in filopodia, however, remain controversial. Consistent with a crucial function of VASP, Dictyostelium mutants lacking VASPs are severely impaired in filopodium formation [ 17 ]. Interestingly, dDia2...

... be addressed (email sam.passey@bristol.ac.uk ). 23 7 2004 © 2004 The Biochemical Society 2004 actin Cdc42 filopodium Rif Numerous cells possess thin actin-rich surface protrusions, which differ in length, thickness, dynamics, localization (apical versus peripheral) and origin...