... BY) . cell homeostasis fibrosis immunometabolism inflammation macrophages monocytes The essence of the innate immune system has been tightly conserved through evolution. It includes, in addition to physical barriers such as the mucosa and skin, a series of myeloid cell subsets. Among them, Mφ...

... The Author(s) 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biomechanics FAK fibrosis pancreatic cancer priming Table 1 Clinical Trials...

... the levels and status of proteins in the ECM via multiple mechanisms. In so doing, Hsp90 regulates ECM dynamics, and changes in Hsp90 levels or activity support the development of ECM-related diseases, like cancer and fibrosis. Consequently, Hsp90 levels may have prognostic value, while inhibition of Hsp90...

...Crisdion Krstevski; Charles D. Cohen; Malathi S.I. Dona; Alexander R. Pinto Single-cell transcriptomics enables inference of context-dependent phenotypes of individual cells and determination of cellular diversity of complex tissues. Cardiac fibrosis is a leading factor in the development of heart...

...Jessica L. Chitty; Yordanos F.I. Setargew; Thomas R. Cox The extracellular matrix (ECM) is a fundamental component of tissue microenvironments and its dysregulation has been implicated in a number of diseases, in particular cancer. Tumour desmoplasia (fibrosis) accompanies the progression of many...

... potential cardiac myocyte: fibroblast coupling connexin fibrosis gap junction ischaemia The trigger for cardiac contraction begins in the sinoatrial node (SAN), where electrical impulses are transmitted through the atria causing them to contract. Signals are delayed at the atrioventricular node...

...Angara Sureshbabu; Hiroshi Okajima; Daisuke Yamanaka; Surya Shastri; Elizabeth Tonner; Colin Rae; Malgorzata Szymanowska; John H. Shand; Shin-Ichiro Takahashi; James Beattie; Gordon J. Allan; David J. Flint Fibrosis involves activation of fibroblasts, increased production of collagen...

... together with glomerular hypertension leads to progressive glomerulosclerosis and tubulointerstitial fibrosis in susceptible individuals. Central to the pathology of DN are cytokines and growth factors such as TGF-β (transforming growth factor β) superfamily members, including BMPs (bone morphogenetic...

... correspondence should be addressed (email akass@ucsd.edu ). 7 8 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 axonal regeneration chronic obstructive pulmonary disease (COPD) fibrosis neurotrophin peptide array phosphodiesterase 4A (PDE4A) cAMP...

... fibrosis. These studies are leading to an appreciation of the complexity of events with multiple pathways involved, but, as the facts emerge, we are finding promising new ways to treat fibrosis and halt the inexorable progression that is a feature of so many fibrotic and remodelling disorders. cytokine...

... expressed upon tissue damage, where it is up-regulated within 24 h of injury. Expression of tenascin-C is down-regulated and protein cleared from the tissue by the time repair is complete. Persistent expression of tenascin-C is associated with fibrotic diseases such as pulmonary fibrosis, scleroderma...

... uptake, metabolism and excretion. However, activation of the PXR also inhibits a deleterious response of the liver to chronic damage – that of fibrosis. The antifibrogenic mode of action is mediated through changes in the expression of genes in hepatic stellate cells and liver macrophages (Kupffers...

...C. D. Richards; C. Kerr; L. Tong; C. Langdon Metabolism of the extracellular matrix (ECM) is a complex process that becomes disregulated in disease states characterized by chronic inflammation of joints, as is seen in rheumatoid arthritis or fibrosis of the lung. The participation of certain...