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Keywords: extracellular-signal-regulated kinase (ERK)
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Articles

Regulation of IL-6-type cytokine responses by MAPKs

Ana P. Costa-Pereira
Journal: Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (1): 59–62.
https://doi.org/10.1042/BST20130267
Published: 23 January 2014
.... This function of ERK2 is not shared by ERK1 and it probably represents an entirely novel function for this prominent kinase. 1 email a.costa-pereira@imperial.ac.uk 5 12 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 cancer extracellular-signal-regulated kinase...
View article titled, Regulation of IL-6-type cytokine responses by MAPKs
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Articles

Regulation of MEK/ERK pathway output by subcellular localization of B-Raf

Catherine Andreadi, Catherine Noble, Bipin Patel, Hong Jin, Maria M. Aguilar Hernandez, Kathryn Balmanno, Simon J. Cook, Catrin Pritchard
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 67–72.
https://doi.org/10.1042/BST20110621
Published: 19 January 2012
... extracellular-signal-regulated kinase (ERK) kinase nucleus Raf signalling The prevailing model for the spatiotemporal regulation of ERKs proposes that MEK acts to anchor ERK in the cytoplasm in resting cells but, on mitogen stimulation, this complex dissociates, and allows entry of active ERK...
View article titled, Regulation of MEK/ERK pathway output by subcellular localization of B-Raf
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Articles

Decoding neurohormone pulse frequency by convergent signalling modules

Krasimira Tsaneva-Atanasova, Christopher J. Caunt, Stephen P. Armstrong, Rebecca M. Perrett, Craig A. McArdle
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 273–278.
https://doi.org/10.1042/BST20110645
Published: 19 January 2012
... The Authors Journal compilation © 2012 Biochemical Society 2012 extracellular-signal-regulated kinase (ERK) frequency decoding gonadotropin-releasing hormone (GnRH) mathematical model nuclear factor of activated T-cells (NFAT) Pulsatile signals are used extensively in biological systems...
View article titled, Decoding neurohormone pulse frequency by convergent signalling modules
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Articles

ERK phosphorylation and nuclear accumulation: insights from single-cell imaging

Christopher J. Caunt, Craig A. McArdle
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 224–229.
https://doi.org/10.1042/BST20110662
Published: 19 January 2012
... Biochemical Society 2012 extracellular-signal-regulated kinase (ERK) high content microscopy mitogen-activated protein kinase (MAPK) mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase (MEK) nuclear accumulation ERK (extracellular-signal-regulated kinase) 1 and 2...
View article titled, ERK phosphorylation and nuclear accumulation: insights from single-cell imaging
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Articles

Effect of exercise and insulin on SREBP-1c expression in human skeletal muscle: potential roles for the ERK1/2 and Akt signalling pathways

T. Boonsong, L. Norton, K. Chokkalingam, K. Jewell, I. Macdonald, A. Bennett, K. Tsintzas
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1310–1311.
https://doi.org/10.1042/BST0351310
Published: 25 October 2007
... Akt/protein kinase B (PKB) exercise extracellular-signal-regulated kinase (ERK) hyperinsulinaemic euglycaemic clamp skeletal muscle sterol-regulatory-element-binding protein 1c (SREBP-1c) SREBP-1c (sterol-regulatory-element-binding protein 1c) is a transcription factor that mediates...
View article titled, Effect of exercise and insulin on SREBP-1c expression in human skeletal muscle: potential roles for the ERK1/2 and Akt signalling pathways
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Articles

Spatiotemporal control of cAMP signalling processes by anchored signalling complexes

E. Jarnæss, K. Taskén
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 931–937.
https://doi.org/10.1042/BST0350931
Published: 25 October 2007
... compartmentalization extracellular-signal-regulated kinase (ERK) phosphodiesterase (PDE) protein kinase A (PKA) Figure 2 AKAP450 targets PKA Type II and PDE4D3 to the centrosomal region in Sertoli cells A similar mechanism operates in cardiomyocytes, where mAKAP binds and targets both PDE4D3 and PKA Type...
View article titled, Spatiotemporal control of cAMP signalling processes by anchored signalling complexes
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Articles

Spatio-temporal regulation of mitogen-activated protein kinase (MAPK) signalling by protein phosphatases

M. Karlsson, M. Mandl, S.M. Keyse
Journal: Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 842–845.
https://doi.org/10.1042/BST0340842
Published: 25 October 2006
.... Bennett A.M. Mol. Cell. Biol. 2005 25 4792 4803 1 To whom correspondence should be addressed (email Stephen.Keyse@cancer.org.uk ). 25 7 2006 © 2006 The Biochemical Society 2006 binding partner extracellular-signal-regulated kinase (ERK) mitogen-activated protein...
View article titled, Spatio-temporal regulation of mitogen-activated protein kinase (MAPK) signalling by protein phosphatases
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Articles

β-Arrestin-recruited phosphodiesterase-4 desensitizes the AKAP79/PKA-mediated switching of β 2 -adrenoceptor signalling to activation of ERK

M.D. Houslay, G.S. Baillie
Journal: Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (6): 1333–1336.
https://doi.org/10.1042/BST0331333
Published: 26 October 2005
... © 2005 The Biochemical Society 2005 A-kinase anchoring protein (AKAP) β 2 -adrenoceptor β-arrestin cAMP desensitization extracellular-signal-regulated kinase (ERK) Cellular Information Processing: A Focus Topic at BioScience2005, held at SECC Glasgow, U.K., 17–21 July 2005...
View article titled, β-Arrestin-recruited phosphodiesterase-4 desensitizes the AKAP79/PKA-mediated switching of β 2 -adrenoceptor signalling to activation of ERK
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Articles

Mitogenic stimulation of transcription by RNA polymerase III

E. Mauger, P.H. Scott
Journal: Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 976–977.
https://doi.org/10.1042/BST0320976
Published: 26 October 2004
... (email p.scott@bio.gla.ac.uk ). 30 6 2004 © 2004 The Biochemical Society 2004 c-Myc extracellular-signal-regulated kinase (ERK) retinoblastoma protein RNA polymerase III TFIIIB transcription Tight regulation of protein synthesis is necessary for normal cell growth control...
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Articles

The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways

M.D. Houslay, G.S. Baillie
Journal: Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1186–1190.
https://doi.org/10.1042/bst0311186
Published: 01 December 2003
... 2003 19 May 2003 © 2003 Biochemical Society 2003 arrestin cAMP extracellular-signal-regulated kinase (ERK) mitogen-activated protein kinase (MAP kinase) phosphodiesterase rolipram Abbreviations used: ERK, extracellular-signal-regulated kinase; PKA, protein kinase...
View article titled, The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways
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Articles

Sprouty: a controversial role in receptor tyrosine kinase signalling pathways

X. Li, L. Wheldon, J.K. Heath
Journal: Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1445–1446.
https://doi.org/10.1042/bst0311445
Published: 01 December 2003
... Biochemical Society 2003 extracellular-signal-regulated kinase (ERK) receptor tyrosine kinase signalling Sprouty Abbreviations used: dSpry, Drosophila Sprouty; EGFR, epidermal growth factor receptor; ERK, extracellular-signal-regulated kinase; EVH domain, Enabled/vasodilator-stimulated...
View article titled, Sprouty: a controversial role in receptor tyrosine kinase signalling pathways
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