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Keywords: extracellular matrix
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Articles
Biochem Soc Trans (2022) 50 (2): 1003–1012.
Published: 11 April 2022
... and POGLUT3 were identified as two novel O -glucosyltransferases that modify a few Notch EGF repeats at sites distinct from those modified by POGLUT1. Comparison of these modification sites revealed a putative consensus sequence which predicted modification of many extracellular matrix proteins including...
Articles
Biochem Soc Trans (2021) 49 (6): 2611–2625.
Published: 16 December 2021
...Abir Chakraborty; Adrienne Lesley Edkins The extracellular matrix (ECM) is a dynamic and organised extracellular network assembled from proteins and carbohydrates exported from the cell. The ECM is critical for multicellular life, providing spatial and temporal cellular cues to maintain tissue...
Articles
Biochem Soc Trans (2020) 48 (6): 2539–2555.
Published: 05 November 2020
...Amir M. Alsharabasy; Sharon A. Glynn; Abhay Pandit The extracellular matrix (ECM) dynamics in tumour tissue are deregulated compared to the ECM in healthy tissue along with disorganized architecture and irregular behaviour of the residing cells. Nitric oxide (NO) as a pleiotropic molecule exerts...
Articles
Biochem Soc Trans (2020) 48 (5): 2335–2345.
Published: 14 October 2020
...Samuel Lewin; Stuart Hunt; Daniel W. Lambert Extracellular vesicles (EV) are implicated in a variety of functions affecting the extracellular matrix (ECM), including matrix degradation, cross-linking of matrix proteins and matrix calcification. These processes are important in many physiological...
Articles
Biochem Soc Trans (2020) 48 (4): 1433–1445.
Published: 14 August 2020
... 21 7 2020 24 7 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 biofabrication extracellular matrix molecular scaffolds osteoarthritis tissue engineering In healthy joint tissue, a layer of subchondral bone (SCB...
Articles
Biochem Soc Trans (2020) 48 (3): 755–764.
Published: 05 May 2020
... consistently promote bone regeneration. Correspondence: Rocky S. Tuan ( tuanr@cuhk.edu.hk ) 28 11 2019 9 4 2020 14 4 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 bone developmental engineering extracellular matrix...
Articles
Biochem Soc Trans (2019) 47 (6): 1651–1660.
Published: 17 December 2019
...Susanne Wiemann; Jacqueline Reinhard; Andreas Faissner The extracellular matrix (ECM) consists of a dynamic network of various macromolecules that are synthesized and released by surrounding cells into the intercellular space. Glycoproteins, proteoglycans and fibrillar proteins are main components...
Articles
Biochem Soc Trans (2019) 47 (6): 1661–1678.
Published: 22 November 2019
...Jessica L. Chitty; Yordanos F.I. Setargew; Thomas R. Cox The extracellular matrix (ECM) is a fundamental component of tissue microenvironments and its dysregulation has been implicated in a number of diseases, in particular cancer. Tumour desmoplasia (fibrosis) accompanies the progression of many...
Articles
Biochem Soc Trans (2019) 47 (6): 1679–1687.
Published: 14 November 2019
...Mavis A.A. Tenkorang; Upendra Chalise; Michael J. Daseke, II; Shelby R. Konfrst; Merry L. Lindsey Myocardial Infarction (MI) initiates a series of wound healing events that begins with up-regulation of an inflammatory response and culminates in scar formation. The extracellular matrix (ECM...
Articles
Biochem Soc Trans (2019) 47 (1): 101–108.
Published: 17 December 2018
...Mohammad Zahied Johan; Michael S. Samuel Reciprocal biochemical and biophysical interactions between tumor cells, stromal cells and the extracellular matrix (ECM) result in a unique tumor microenvironment that determines disease outcome. The cellular component of the tumor microenvironment...
Articles
Biochem Soc Trans (2018) 46 (3): 631–639.
Published: 09 May 2018
... (e.g. [ 61 ]), though enzyme activities in situ are rarely reported. Recently, the surface of exosomes has been reported to contain active proteases and glycosidases that may be responsible for remodelling of extracellular matrix (ECM) [ 62 ], with EVs being proposed as active components of the ECM...
Articles
Biochem Soc Trans (2017) 45 (1): 229–236.
Published: 15 February 2017
... remodeling of the stromal extracellular matrix (ECM) by CAFs are important contributors to tumor cell migration and invasion, which are critical for cancer progression from a primary tumor to metastatic disease. In this review, we discuss key paracrine signaling pathways between CAFs and cancer cells...
Articles
Biochem Soc Trans (2016) 44 (5): 1347–1354.
Published: 19 October 2016
...Elena Rainero The extracellular matrix (ECM) is a network of secreted proteins that, beyond providing support for tissues and organs, is involved in the regulation of a variety of cell functions, including cell proliferation, polarity, migration and oncogenic transformation. ECM homeostasis...
Articles
Biochem Soc Trans (2016) 44 (5): 1465–1473.
Published: 19 October 2016
... cellular environments. The extracellular matrix contains information regarding tissue architecture and its mechanical properties that is transmitted to the cell via integrin receptors. In this review, I describe various examples of modulation of the BMP pathway by integrins. In the case of the Drosophila...
Articles
Biochem Soc Trans (2015) 43 (3): 482–488.
Published: 01 June 2015
... dynamics and the extracellular matrix (ECM), showing that Cx43 plays diverse roles in co-ordinating wound closure events. It is clear that both CMPs and antisense oligonucleotides hold therapeutic potential, however maintaining Cx43 expression may be beneficial to the cell by preserving other non-channel...
Articles
Biochem Soc Trans (2015) 43 (1): 122–128.
Published: 26 January 2015
...Katarzyna I. Wolanska; Mark R. Morgan The biophysical, mechanical and chemical characteristics of extracellular matrixes influence many cellular functions to control tissue homoeostasis and drive progression of cancer and inflammatory diseases. To maintain normal tissue function, fibronectin-rich...
Articles
Biochem Soc Trans (2013) 41 (4): 995–1001.
Published: 18 July 2013
... The Authors Journal compilation © 2013 Biochemical Society 2013 actin cell adhesion extracellular matrix integrin-linked kinase (ILK) pseudokinase signalling In order to establish and maintain structural organization and proper function of the tissue, cells need to sense and process...
Articles
Biochem Soc Trans (2007) 35 (5): 857–861.
Published: 25 October 2007
...P.T. Kovanen Mast cells are present in advanced human atherosclerotic plaques, where they are thought to exert multiple effects on their neighbouring cells and on the extracellular matrix of the plaque. Extensive efforts at delineating their role(s) in atherosclerotic plaques have unravelled...
Articles
Biochem Soc Trans (2007) 35 (5): 849–852.
Published: 25 October 2007
... to structural changes deleterious to function. Finally, the extracellular matrix of vascular tissue is a multicomponent system and the role of other major constituents, such as elastin and glycosaminoglycans, in modifying tissue properties should be considered. Some details of newer methods being developed...
Articles
Biochem Soc Trans (2007) 35 (4): 643–646.
Published: 20 July 2007
... pathways, and these in turn can lead to changes in matrix turnover. This is a long way from the traditional view of the role of the extracellular matrix, or ‘ground substance’, in filling the spaces between the cells and providing physical support for them. Just over 100 delegates assembled at Sheffield...
Articles
Biochem Soc Trans (2007) 35 (4): 689–691.
Published: 20 July 2007
... on their interaction with specific inhibitors. The effect of new, hydroxamatebased inhibitors on MMP isolated from bovine brain is evaluated. bovine brain endogenous proteinase inhibitor extracellular matrix hydroxamate matrix metalloproteinase synthetic inhibitor MMPs (matrix metalloproteinases...
Articles
Biochem Soc Trans (2007) 35 (4): 672–676.
Published: 20 July 2007
... (extracellular matrix) during ovulation is critically dependent on the catalysis of HC·HA generation by TSG-6, with TSG - 6 −/− mice being female infertile because of failure of HA cross-linking. It has been shown recently that TSG-6-mediated HC·HA formation is essential for the formation of HA-rich pericellular...
Articles
Biochem Soc Trans (2007) 35 (4): 692–694.
Published: 20 July 2007
...G. Haddock; A.K. Cross; S. Allan; B. Sharrack; J. Callaghan; R.A.D. Bunning; D.J. Buttle; M.N. Woodroofe The ECM (extracellular matrix) is a complex molecular framework that provides physical support to cells and tissues, while also providing signals for cell growth, migration, differentiation...
Articles
Biochem Soc Trans (2007) 35 (4): 677–679.
Published: 20 July 2007
... compilation © 2007 Biochemical Society 2007 cartilage extracellular matrix frictional property joint tissue engineering tribology Articular cartilage has a crucial role in allowing diversity of movement under high-load-bearing conditions. The functional properties of articular cartilage may...
Articles
Biochem Soc Trans (2007) 35 (4): 695–697.
Published: 20 July 2007
... of tissue repair. These events must be tightly regulated. Excessive deposition of scar tissue is the major hallmark of fibrotic disease. Tenascin-C is an extracellular matrix glycoprotein that is transiently expressed upon tissue injury, where it is specifically localized to the wound edge, and persistently...
Articles
Biochem Soc Trans (2006) 34 (6): 1261–1266.
Published: 25 October 2006
...G.J. del Zoppo; R. Milner; T. Mabuchi; S. Hung; X. Wang; J.A. Koziol The integrity of the cerebral microvasculature depends on the interaction between its component cells and the extracellular matrix, as well as reorganized cell–cell interactions. In the central nervous system, matrix adhesion...
Articles
Biochem Soc Trans (2006) 34 (3): 454–455.
Published: 22 May 2006
... and Structure: Biochemical Society Focused Meeting held at Royal Holloway University of London, Egham Hill, U.K., 9–10 January 2006. Organized and edited by B. Mulloy (NIBSC, U.K.) and C. Rider (Royal Holloway University of London, U.K.). ECM extracellular matrix HS heparan sulphate HSPG HS...
Articles
Biochem Soc Trans (2005) 33 (6): 1254–1255.
Published: 26 October 2005
...J.R. Higginson; S.J. Winder Dystroglycan, a ubiquitous membrane-spanning cell adhesion molecule, is a crucial link between the actin cytoskeleton and the extracellular matrix. With a wide expression pattern and multiple interacting proteins, not only is dystroglycan now thought to be important...
Articles
Biochem Soc Trans (2004) 32 (3): 438–442.
Published: 01 June 2004
... © 2004 Biochemical Society 2004 adhesion epidermal growth factor (EGF) extracellular matrix growth factor receptor integrin signalling Abbreviations used: EGF(R), epidermal growth factor (receptor); Egr-1, early growth response gene product 1; ERK, extracellular-signal...