...Jana Wolf; Lori A. Passmore Poly(A) tails are important regulators of mRNA stability and translational efficiency. Cytoplasmic removal of poly(A) tails by 3′→5′ exonucleases (deadenylation) is the rate-limiting step in mRNA degradation. Two exonuclease complexes contribute the majority...

... exonuclease exosome RNA degradation RNA processing RNA surveillance The exosome is a multiprotein nuclease complex that functions in RNA processing and turnover. This complex was first discovered in Saccharomyces cerevisiae and has been extensively studied in this organism, whereas the functions...

...Sophia Hartung; Karl-Peter Hopfner The RNA exosome is a multisubunit exonuclease involved in numerous RNA maturation and degradation processes. Exosomes are found in eukaryotes and archaea and are related to bacterial polynucleotide phosphorylates. Over the past years structural and biochemical...