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Keywords: exocytosis
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Articles
Biochem Soc Trans (2022) 50 (4): 1157–1167.
Published: 12 August 2022
... imaging techniques were unable to visualize the membrane transformation underlying vesicle exocytosis and endocytosis. The revolution of fluorescent protein labeling brought many new interesting applications to study proteins and lipids involved in membrane fusion and fission, including...
Articles
Biochem Soc Trans (2021) 49 (6): 2841–2851.
Published: 16 November 2021
..., primarily in endo- and exocytosis. In this review, I summarize recent advances in our understanding on how these non-canonical functions differ from canonical macroautophagy, and contribute to immune activation and viral replication. Understanding these pathways will allow us to harness them...
Articles
Biochem Soc Trans (2018) 46 (2): 235–247.
Published: 22 February 2018
...Hao Xu; Na-Ryum Bin; Shuzo Sugita Mast cells play pivotal roles in innate and adaptive immunities but are also culprits in allergy, autoimmunity, and cardiovascular diseases. Mast cells respond to environmental changes by initiating regulated exocytosis/secretion of various biologically active...
Articles
Biochem Soc Trans (2013) 41 (6): 1557–1561.
Published: 20 November 2013
... proposed to ensure gliotransmitter release: non-exocytotic release from cytosolic pools through plasma membrane proteins, and Ca 2+ -regulated exocytosis through the fusion of gliotransmitter-storing secretory organelles. Regulated Ca 2+ -dependent glial exocytosis has received much attention...
Articles
Biochem Soc Trans (2012) 40 (5): 1117–1122.
Published: 19 September 2012
... compilation © 2012 Biochemical Society 2012 cytoskeleton endocytosis exocytosis leucine-rich repeat kinase 2 (LRRK2) PD (Parkinson's disease) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting more than 1 million people in North America and more than 4...
Articles
Biochem Soc Trans (2011) 39 (5): 1115–1119.
Published: 21 September 2011
... or granules (‘carriers’) in the final stages of constitutive or regulated exocytosis undergo four discrete stages: (i) approach, (ii) docking, (iii) priming, and (iv) fusion. Transfer of carriers through these four stages relies on the actions of many different myosin motor proteins, particularly non-muscle...
Articles
Biochem Soc Trans (2010) 38 (2): 457–459.
Published: 22 March 2010
... spontaneous action potentials, allowing the presynaptic control of glutamate exocytosis to be studied. Recent developments have greatly increased the sensitivity with which the bioenergetics of the intra-synaptosomal mitochondria can be investigated. 1 email dnicholls@buckinstitute.org 23 8...
Articles
Biochem Soc Trans (2010) 38 (1): 163–166.
Published: 19 January 2010
...Jennifer Greaves; Gerald R. Prescott; Oforiwa A. Gorleku; Luke H. Chamberlain The SNARE (soluble N -ethylmaleimide-sensitive fusion protein-attachment protein receptor) protein SNAP-25 (25 kDa synaptosome-associated protein) is essential for regulated exocytosis in neuronal and neuroendocrine cells...
Articles
Biochem Soc Trans (2010) 38 (1): 167–171.
Published: 19 January 2010
...Nicolas Vitale Exocytosis of hormones occurs through the fusion of large dense-core secretory vesicles with the plasma membrane. This highly regulated process involves key proteins such as SNAREs (soluble N -ethylmaleimide-sensitive fusion protein-attachment protein receptors) and also specific...
Articles
Biochem Soc Trans (2010) 38 (1): 192–198.
Published: 19 January 2010
... to syntaxin-1 are important to regulate subsequent steps in the secretory pathway: docking (‘closed’ syntaxin) and fusion (‘open’ syntaxin). docking electron microscopy exocytosis filamentous actin (F-actin) Munc18-1 syntaxin-1 In electron micrographs of synapses and chromaffin cells...
Articles
Biochem Soc Trans (2010) 38 (1): 213–216.
Published: 19 January 2010
... protein receptor) complex. A plethora of molecules such as members of the MUNC13, MUNC18, complexin and synaptotagmin families act along with the SNARE complex to enable calcium-regulated synaptic vesicle exocytosis. The synaptotagmins are localized to synaptic vesicles by an N-terminal transmembrane...
Articles
Biochem Soc Trans (2010) 38 (1): 172–176.
Published: 19 January 2010
... exocytosis Munc18-1 Rab3 UNC-18 Alcohol is the most used and abused substance in the world and drunkenness is correlated with a host of social problems. Despite the prevalence in its use, the exact physiological and molecular mechanisms underlying intoxication and alcohol abuse remain poorly...
Articles
Biochem Soc Trans (2010) 38 (1): 199–204.
Published: 19 January 2010
... and the regulation of their exocytosis. In the present paper, we summarize the current knowledge on the roles of myosin Va in the different steps of dense-core vesicle biogenesis and exocytosis, and compare findings obtained from different cell types and experimental systems. Figure 1 Mode of interaction...
Articles
Biochem Soc Trans (2008) 36 (3): 294–299.
Published: 21 May 2008
... pattern. In the last few years, we have therefore combined live cell imaging and electrophysiology to study insulin secretion at the level of individual granules, as they approach the plasma membrane, undergo exocytosis and finally release their insulin cargo. In the present paper, we review evidence...
Articles
Biochem Soc Trans (2006) 34 (5): 683–686.
Published: 25 October 2006
..., and the interaction of these two proteins is required for the assembly of this complex and its tethering function in exocytosis. Sec1p binds to assembled SNARE complexes, possibly stabilizing them. Another effector of Sec4p, Sro7p, interacts with the exocytic t-SNARE Sec9p and this interaction is required for Sec4p's...
Articles
Biochem Soc Trans (2006) 34 (5): 671–674.
Published: 25 October 2006
... events of these organelles, which precede their exocytosis. Consistent with these roles, interactions of myosin Va with an array of well-known proteins involved in regulated protein secretion have been documented. Each heavy chain of the homodimeric myosin Va consists of an N-terminal head domain...
Articles
Biochem Soc Trans (2006) 34 (5): 675–678.
Published: 25 October 2006
...G.A. Rutter; M.K. Loder; M.A. Ravier Minute-to-minute control of the release of insulin by pancreatic β-cells in response to glucose or other stimuli requires the precise delivery of large dense-core vesicles to the plasma membrane and regulated exocytosis. At present, the precise spatial...
Articles
Biochem Soc Trans (2006) 34 (4): 472–473.
Published: 21 July 2006
... tools to study the relevance of PKA anchoring in cellular processes. 1 To whom correspondence should be addressed (email klussmann@fmp-berlin.de ). 6 4 2006 © 2006 The Biochemical Society 2006 A-kinase-anchoring protein (AKAP) aquaporin-2 (AQP2) cAMP exocytosis protein...
Articles
Biochem Soc Trans (2005) 33 (6): 1341–1344.
Published: 26 October 2005
...A. Morgan; R.D. Burgoyne; J.W. Barclay; T.J. Craig; G.R. Prescott; L.F. Ciufo; G.J.O. Evans; M.E. Graham PKC (protein kinase C) has been known for many years to modulate regulated exocytosis in a wide variety of cell types. In neurons and neuroendocrine cells, PKC regulates several different stages...
Articles
Biochem Soc Trans (2005) 33 (6): 1316–1318.
Published: 26 October 2005
... Society 2005 A-kinase anchoring protein (AKAP) aquaporin-2 (AQP2) cAMP compartmentalization exocytosis protein kinase A (PKA) Various hormones and other signals induce the generation of cAMP by activation of adenylate cyclase, most often via G-protein-coupled receptors. The most important...
Articles
Biochem Soc Trans (2005) 33 (6): 1350–1353.
Published: 26 October 2005
... and how this phosphorylation may control its function in the SV life cycle. 1 To whom correspondence should be addressed (email m.cousin@ed.ac.uk ). 13 6 2005 © 2005 The Biochemical Society 2005 exocytosis neuron phosphorylation plasticity synaptophysin tyrosine...
Articles
Biochem Soc Trans (2003) 31 (4): 842–847.
Published: 01 August 2003
... to be present in the cytosol of rat pancreatic β-cells and rat insulinoma INS-1 cells. Capacitance measurements revealed that exocytosis of primed granules was not affected by the presence of a monoclonal antibody against NSF, mAb 2E5, suggesting that NSF is not involved in the fusion process. The antibody...
Articles
Biochem Soc Trans (2003) 31 (4): 848–850.
Published: 01 August 2003
... release in mice, Munc18-1, results in a complete block of exocytosis. Manipulation of Munc18-1 protein levels in neurons and adrenal chromaffin cells argues for a positive role of this protein in vesicle secretion, as overexpression results in an increase in vesicle secretion. A decrease in Munc18-1...
Articles
Biochem Soc Trans (2003) 31 (4): 819–823.
Published: 01 August 2003
..., the application of TIR-FM to membrane trafficking events in both non-excitable and excitable cells has been an area of notable expansion and fruition. This review gives a brief overview of that literature, with emphasis on the study of the regulation of exocytosis and endocytosis in excitable cells using TIR-FM...
Articles
Biochem Soc Trans (2003) 31 (4): 833–836.
Published: 01 August 2003
...)] or the lumen [neuropeptide Y (NPY)·pH-insensitive yellow fluorescent protein (Venus)] by evanescent wave microscopy. Unexpectedly, the frequency of NPY·Venus release events was only 17–27% of that of vesicle fusion reported with synapto·pHluorin, but not phogrin·EGFP, indicating that exocytosis of cargo...
Articles
Biochem Soc Trans (2003) 31 (4): 837–841.
Published: 01 August 2003
...L. Tabares; M. Lindau; G. Alvarez de Toledo We have studied exocytosis in rat peritoneal mast cells by cell-attached patch amperometry. Step increases in capacitance were accompanied by typical amperometric spikes due to the release of 5-hydroxytryptamine (serotonin), indicating exocytosis...