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Keywords: exocytosis
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Articles
Biochem Soc Trans (2021) 49 (6): 2841–2851.
Published: 16 November 2021
..., primarily in endo- and exocytosis. In this review, I summarize recent advances in our understanding on how these non-canonical functions differ from canonical macroautophagy, and contribute to immune activation and viral replication. Understanding these pathways will allow us to harness them...
Articles
Biochem Soc Trans (2018) 46 (2): 235–247.
Published: 22 February 2018
...Hao Xu; Na-Ryum Bin; Shuzo Sugita Mast cells play pivotal roles in innate and adaptive immunities but are also culprits in allergy, autoimmunity, and cardiovascular diseases. Mast cells respond to environmental changes by initiating regulated exocytosis/secretion of various biologically active...
Articles
Biochem Soc Trans (2013) 41 (6): 1557–1561.
Published: 20 November 2013
... proposed to ensure gliotransmitter release: non-exocytotic release from cytosolic pools through plasma membrane proteins, and Ca 2+ -regulated exocytosis through the fusion of gliotransmitter-storing secretory organelles. Regulated Ca 2+ -dependent glial exocytosis has received much attention...
Articles
Biochem Soc Trans (2012) 40 (5): 1117–1122.
Published: 19 September 2012
... of LRRK2 in the regulation of vesicle trafficking. cytoskeleton endocytosis exocytosis leucine-rich repeat kinase 2 (LRRK2) This research was supported by Fondazione Banco di Sardegna [grant number 970/2010.0375] and Regione Sardegna [grant number CRP-17171/2009]. M.G.D.G...
Articles
Biochem Soc Trans (2011) 39 (5): 1115–1119.
Published: 21 September 2011
... in general. 1 To whom correspondence should be addressed (email fb1@mole.bio.cam.ac.uk ). 4 4 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 actin exocytosis fusion myosin secretion vesicle Secretion/exocytosis is a fundamental mechanism...
Articles
Biochem Soc Trans (2010) 38 (2): 457–459.
Published: 22 March 2010
... spontaneous action potentials, allowing the presynaptic control of glutamate exocytosis to be studied. Recent developments have greatly increased the sensitivity with which the bioenergetics of the intra-synaptosomal mitochondria can be investigated. References 1 Dunkley P.R. Jarvie P.E...
Articles
Biochem Soc Trans (2010) 38 (1): 172–176.
Published: 19 January 2010
.... 2004 24 10679 10686 17 Jahn R. Lang T. Südhof T.C. Membrane fusion Cell 2003 112 519 533 18 Burgoyne R.D. Morgan A. Secretory granule exocytosis Physiol. Rev. 2003 83 581 632 19 Grosshans B.L. Ortiz D. Novick P. Rabs...
Articles
Biochem Soc Trans (2010) 38 (1): 199–204.
Published: 19 January 2010
... and the regulation of their exocytosis. In the present paper, we summarize the current knowledge on the roles of myosin Va in the different steps of dense-core vesicle biogenesis and exocytosis, and compare findings obtained from different cell types and experimental systems. Table 1 Effects of myosin Va...
Articles
Biochem Soc Trans (2010) 38 (1): 163–166.
Published: 19 January 2010
...Jennifer Greaves; Gerald R. Prescott; Oforiwa A. Gorleku; Luke H. Chamberlain The SNARE (soluble N -ethylmaleimide-sensitive fusion protein-attachment protein receptor) protein SNAP-25 (25 kDa synaptosome-associated protein) is essential for regulated exocytosis in neuronal and neuroendocrine cells...
Articles
Biochem Soc Trans (2010) 38 (1): 167–171.
Published: 19 January 2010
...Nicolas Vitale Exocytosis of hormones occurs through the fusion of large dense-core secretory vesicles with the plasma membrane. This highly regulated process involves key proteins such as SNAREs (soluble N -ethylmaleimide-sensitive fusion protein-attachment protein receptors) and also specific...
Articles
Biochem Soc Trans (2010) 38 (1): 192–198.
Published: 19 January 2010
... heidi.de.wit@cncr.vu.nl 30 3 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 docking electron microscopy exocytosis filamentous actin (F-actin) Munc18-1 syntaxin-1 In electron micrographs of synapses and chromaffin cells, many synaptic and secretory...
Articles
Biochem Soc Trans (2010) 38 (1): 213–216.
Published: 19 January 2010
... protein receptor) complex. A plethora of molecules such as members of the MUNC13, MUNC18, complexin and synaptotagmin families act along with the SNARE complex to enable calcium-regulated synaptic vesicle exocytosis. The synaptotagmins are localized to synaptic vesicles by an N-terminal transmembrane...
Articles
Biochem Soc Trans (2008) 36 (3): 294–299.
Published: 21 May 2008
... pattern. In the last few years, we have therefore combined live cell imaging and electrophysiology to study insulin secretion at the level of individual granules, as they approach the plasma membrane, undergo exocytosis and finally release their insulin cargo. In the present paper, we review evidence...
Articles
Biochem Soc Trans (2006) 34 (5): 671–674.
Published: 25 October 2006
... events of these organelles, which precede their exocytosis. Consistent with these roles, interactions of myosin Va with an array of well-known proteins involved in regulated protein secretion have been documented. 1 To whom correspondence should be addressed (email hans-hermann.gerdes...
Articles
Biochem Soc Trans (2006) 34 (5): 675–678.
Published: 25 October 2006
...G.A. Rutter; M.K. Loder; M.A. Ravier Minute-to-minute control of the release of insulin by pancreatic β-cells in response to glucose or other stimuli requires the precise delivery of large dense-core vesicles to the plasma membrane and regulated exocytosis. At present, the precise spatial...
Articles
Biochem Soc Trans (2006) 34 (5): 683–686.
Published: 25 October 2006
... complex containing eight conserved gene products, each required for exocytosis [ 8 , 9 ]. Early genetic studies suggested that one subunit, Sec15p, might act downstream of Sec4p [ 10 ] and subsequent biochemical analysis confirmed that Sec15p is a bona fide Sec4p effector as it directly binds Sec4-GTP...
Articles
Biochem Soc Trans (2006) 34 (4): 472–473.
Published: 21 July 2006
... tools to study the relevance of PKA anchoring in cellular processes. 1 To whom correspondence should be addressed (email klussmann@fmp-berlin.de ). 6 4 2006 © 2006 The Biochemical Society 2006 A-kinase-anchoring protein (AKAP) aquaporin-2 (AQP2) cAMP exocytosis protein...
Articles
Biochem Soc Trans (2005) 33 (6): 1341–1344.
Published: 26 October 2005
...A. Morgan; R.D. Burgoyne; J.W. Barclay; T.J. Craig; G.R. Prescott; L.F. Ciufo; G.J.O. Evans; M.E. Graham PKC (protein kinase C) has been known for many years to modulate regulated exocytosis in a wide variety of cell types. In neurons and neuroendocrine cells, PKC regulates several different stages...
Articles
Biochem Soc Trans (2005) 33 (6): 1316–1318.
Published: 26 October 2005
.... Theilig F. Schmitt R. Vossebein L. Tamma G. Beyermann M. J. Biol. Chem. 2004 279 26654 26665 21 6 2005 © 2005 The Biochemical Society 2005 A-kinase anchoring protein (AKAP) aquaporin-2 (AQP2) cAMP compartmentalization exocytosis protein kinase A (PKA...
Articles
Biochem Soc Trans (2005) 33 (6): 1350–1353.
Published: 26 October 2005
... and how this phosphorylation may control its function in the SV life cycle. 1 To whom correspondence should be addressed (email m.cousin@ed.ac.uk ). 13 6 2005 © 2005 The Biochemical Society 2005 exocytosis neuron phosphorylation plasticity synaptophysin tyrosine...
Articles
Biochem Soc Trans (2003) 31 (4): 842–847.
Published: 01 August 2003
... to be present in the cytosol of rat pancreatic β-cells and rat insulinoma INS-1 cells. Capacitance measurements revealed that exocytosis of primed granules was not affected by the presence of a monoclonal antibody against NSF, mAb 2E5, suggesting that NSF is not involved in the fusion process. The antibody...
Articles
Biochem Soc Trans (2003) 31 (4): 848–850.
Published: 01 August 2003
... release in mice, Munc18-1, results in a complete block of exocytosis. Manipulation of Munc18-1 protein levels in neurons and adrenal chromaffin cells argues for a positive role of this protein in vesicle secretion, as overexpression results in an increase in vesicle secretion. A decrease in Munc18-1...
Articles
Biochem Soc Trans (2003) 31 (4): 819–823.
Published: 01 August 2003
..., the application of TIR-FM to membrane trafficking events in both non-excitable and excitable cells has been an area of notable expansion and fruition. This review gives a brief overview of that literature, with emphasis on the study of the regulation of exocytosis and endocytosis in excitable cells using TIR-FM...
Articles
Biochem Soc Trans (2003) 31 (4): 833–836.
Published: 01 August 2003
...)] or the lumen [neuropeptide Y (NPY)·pH-insensitive yellow fluorescent protein (Venus)] by evanescent wave microscopy. Unexpectedly, the frequency of NPY·Venus release events was only 17–27% of that of vesicle fusion reported with synapto·pHluorin, but not phogrin·EGFP, indicating that exocytosis of cargo...
Articles
Biochem Soc Trans (2003) 31 (4): 837–841.
Published: 01 August 2003
...L. Tabares; M. Lindau; G. Alvarez de Toledo We have studied exocytosis in rat peritoneal mast cells by cell-attached patch amperometry. Step increases in capacitance were accompanied by typical amperometric spikes due to the release of 5-hydroxytryptamine (serotonin), indicating exocytosis...