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Keywords: exchange protein directly activated by cAMP (Epac)
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Articles
Biochem Soc Trans (2014) 42 (2): 257–264.
Published: 20 March 2014
.... Consistent with this, a cAMP-responsive signalling complex that includes Epac1 and PDE4D3 has been identified in cardiac myocytes [ 28 ]. cAMP cardiac disease exchange protein directly activated by cAMP (Epac) G-protein-coupled receptor (GPCR) heart failure phosphodiesterase cAMP...
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Articles
Biochem Soc Trans (2014) 42 (1): 89–97.
Published: 23 January 2014
... the blood and the surrounding tissue. The vasculature expresses three cAMP effector proteins: PKA (protein kinase A), CNG (cyclic-nucleotide-gated) ion channels, and the most recently discovered Epacs (exchange proteins directly activated by cAMP). Epacs are a family of GEFs (guanine-nucleotide-exchange...
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Biochem Soc Trans (2012) 40 (1): 215–218.
Published: 19 January 2012
... cytokine exchange protein directly activated by cAMP (Epac) Janus kinase (JAK) signal transducer and activator of transcription (STAT) suppressor of cytokine signalling (SOCS) ubiquitin ligase Cytokines control many important biological responses, including haemopoiesis, inflammation and T...
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Biochem Soc Trans (2012) 40 (1): 219–223.
Published: 19 January 2012
... Society 2012 allostery cAMP cGMP chemical shift covariance analysis (CHESCA) exchange protein directly activated by cAMP (Epac) nuclear magnetic resonance (NMR) protein dynamics cAMP is an ancient second messenger that controls a multitude of essential cellular processes by binding...
Articles
Biochem Soc Trans (2012) 40 (1): 51–57.
Published: 19 January 2012
... in brain and heart, and discuss the potential implication of Epac in CNS (central nervous system) and cardiac disorders. cAMP exchange protein directly activated by cAMP (Epac) G-protein-coupled receptor guanine-nucleotide-exchange factor heart failure protein kinase A (PKA) Cardiac...
Articles
Biochem Soc Trans (2006) 34 (4): 468–471.
Published: 21 July 2006
... into the complexities of this finely tuned messenger system and its dynamic interaction with other signalling pathways. adenylate cyclase (AC) calcium cAMP cyclic nucleotide-gated channel (CNGC) exchange protein directly activated by cAMP (Epac) fluorescence resonance energy transfer (FRET) phosphodiesterase...
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Biochem Soc Trans (2005) 33 (6): 1330–1332.
Published: 26 October 2005
... disease cAMP exchange protein directly activated by cAMP (EPAC) guanine nucleotide-exchange factor (GEF) protein kinase A (PKA) Rap Although the effects of cAMP-mediated signalling are wide ranging, there are only two general cAMP effectors, i.e. proteins that are activated by binding to cAMP...
Articles
Articles
Biochem Soc Trans (2003) 31 (1): 83–86.
Published: 01 February 2003
... meeting held at University of Liverpool, Liverpool, 4–6 September 2002 6 September 2002 Copyright 2003 Biochemical Society 2003 cAMP exchange protein directly activated by cAMP (Epac) integrin Abbreviations used: AF6; ALL1-fused gene from chromosome 6; Epac, exchange...