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Keywords: evolution of DNA
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Biochem Soc Trans (2014) 42 (4): 1159–1167.
Published: 11 August 2014
... is achieved by direct readout in the minor groove. However, the level of sequence specificity observed is much less than that of DNA major groove-binding helix–turn–helix proteins. We suggest that the evolution of DNA-binding proteins following the RNA to DNA genome transition represents the major advantage...