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Keywords: evolution
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Articles
Biochem Soc Trans (2023) 51 (5): 1947–1956.
Published: 16 October 2023
..., and the SAR), we propose that whilst polyP synthesising machinery was present in the ancestral eukaryote, most lineages subsequently lost it during evolution. The analysis of the bacteria-acquired amoeba PPK1 and its unique polyP physiology suggests that eukaryote cells must have developed mechanisms to limit...
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Biochem Soc Trans (2023) 51 (3): 1191–1199.
Published: 24 May 2023
... for prenylated proteins and shuttles them between membrane compartments by concealing their hydrophobic lipid moiety from the cytosol [ 32 , 33 ]. Although KRAS4A is also prenylated, it is not a binding partner of PDE6δ [ 14 ] ( Figure 1 ). alternative splicing evolution KRAS KRAS4A KRAS4B oncogene...
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Biochem Soc Trans (2021) 49 (5): 1997–2006.
Published: 16 August 2021
... a transformative agreement with Max Planck Digital Library. cell proliferation evolution neocortex development neural progenitor cells neurogenesis The neocortex is the largest part of the mammalian cerebral cortex and is the seat of higher cognitive functions, such as thinking and language...
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Articles
Biochem Soc Trans (2019) 47 (5): 1533–1542.
Published: 23 October 2019
... Limited on behalf of the Biochemical Society 2019 2 8 2019 30 9 2019 2 10 2019 Correspondence: Renwick Dobson ( renwick.dobson@canterbury.ac.nz ) evolution fitness molecular adaptation protein evolution It is common to assume natural selection as the ultimate...
Articles
Biochem Soc Trans (2019) 47 (1): 239–249.
Published: 15 January 2019
... by Portland Press Limited on behalf of the Biochemical Society 2019 classification DNA polymerases DNA replication evolution PolD proofreading DNA replication is one of the most important functions in living organisms and viruses. It ensures the integrity of the genome and the accurate...
Articles
Biochem Soc Trans (2018) 46 (2): 285–294.
Published: 27 February 2018
...). Published by Portland Press Limited on behalf of the Biochemical Society 2018 evolution light-harvesting complexes membrane complexes photosynthesis photosystems structure The photochemical functions of oxygenic photosynthesis are performed by two photosystems, designated photosystem I...
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Biochem Soc Trans (2016) 44 (1): 253–259.
Published: 09 February 2016
..., inositol phosphates and polyP, speculating on the evolution of these relationships. 1 To whom correspondence should be addressed (email dmcbado@ucl.ac.uk ). 25 11 2015 © 2016 Authors; published by Portland Press Limited 2016 PolyP is the simplest biological polymer...
Articles
Biochem Soc Trans (2015) 43 (6): 1172–1176.
Published: 27 November 2015
...David Heckmann How did the complex metabolic systems we observe today evolve through adaptive evolution? The fitness landscape is the theoretical framework to answer this question. Since experimental data on natural fitness landscapes is scarce, computational models are a valuable tool to predict...
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Articles
Biochem Soc Trans (2014) 42 (6): 1684–1691.
Published: 17 November 2014
... in orthologous proteins in different organisms? And, most interestingly, why has the moonlighting protein not been replaced by two proteins, each of which performs a specialized function? adaptive conflict bifunctional protein evolution gene duplication moonlighting © The Authors Journal...
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Biochem Soc Trans (2014) 42 (6): 1704–1708.
Published: 17 November 2014
... compilation © 2014 Biochemical Society 2014 antibodies complementarity determining regions evolution moonlighting protein structure The traditional dogma of biology has been that DNA is copied into RNA which encodes a protein with a single function. Over the last 10–15 years, this dogma has...
Articles
Biochem Soc Trans (2014) 42 (6): 1715–1719.
Published: 17 November 2014
...Carlos Gancedo; Carmen-Lisset Flores; Juana M. Gancedo The present article addresses the possibilities offered by yeasts to study the problem of the evolution of moonlighting proteins. It focuses on data available on hexokinase from Saccharomyces cerevisiae that moonlights in catabolite repression...
Articles
Biochem Soc Trans (2014) 42 (4): 985–988.
Published: 11 August 2014
... and reproduction in any medium, provided the original work is properly cited. catalysis evolution glycolysis origin of life origin of metabolism pentose phosphate pathway replicator RNA We are far from understanding the origin of life, as several of the problems associated with it are yet...
Articles
Biochem Soc Trans (2014) 42 (3): 625–630.
Published: 22 May 2014
... in the mechanism of regeneration provides evidence for the importance of local evolution, rather than a purely ancestral mechanism. The three-finger protein called Prod1 is discussed in the present article as an exemplar of this approach. © The Authors Journal compilation © 2014 Biochemical Society 2014...
Articles
Biochem Soc Trans (2014) 42 (2): 473–478.
Published: 20 March 2014
... relationships have also been obtained from parasitic protists. These organisms, including kinetoplastid and apicomplexan parasites, are particularly interesting, both because of their relevance as pathogens and because of their phylogenetic diversity and host–parasite co-evolution which has led to specialized...
Articles
Biochem Soc Trans (2014) 42 (2): 295–301.
Published: 20 March 2014
... distributed under the terms of the Creative Commons Attribution Licence (CC-BY) ( http://creativecommons.org/licenses/by/3.0/ ) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. cAMP cardiac arrhythmia caveolin 3 evolution...
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Biochem Soc Trans (2013) 41 (6): 1383–1391.
Published: 20 November 2013
... (Cas) system draft genome evolution © The Authors Journal compilation © 2013 Biochemical Society 2013 CRISPR loci, together with cas genes form the CRISPR–Cas immune system, which is present in ~46% of bacteria and almost 90% of archaea [ 17 , 18 ]. CRISPR loci typically consist...
Articles
Biochem Soc Trans (2013) 41 (6): 1532–1535.
Published: 20 November 2013
... in the inclusion of Alu exon into mature transcripts. Moreover, I present the mechanism that represses such a major inclusion of Alu exons and instead enables a gradual evolution of Alu elements into new exons. 1 email j.ule@ucl.ac.uk 13 8 2013 Alu elements are retrotransposable elements...
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Biochem Soc Trans (2013) 41 (6): 1392–1400.
Published: 20 November 2013
... homologous with viral or plasmid DNA and integrated into the CRISPR loci. Most of the Cas proteins evolve under relaxed purifying selection and some underwent dramatic structural rearrangements during evolution. In many cases, CRISPR–Cas system components are replaced either by homologous or by analogous...
Includes: Supplementary data
Articles
Biochem Soc Trans (2013) 41 (5): 1137–1140.
Published: 23 September 2013
... email birte.hoecker@tuebingen.mpg.de 5 6 2013 © 2013 The Authors 2013 (βα) 8 -barrel computational design evolution flavodoxin-like fold fold fragments protein chimaera The ubiquitous (βα) 8 -barrel, which is a typical enzyme fold, has been hypothesized to have evolved...
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Biochem Soc Trans (2013) 41 (4): 1017–1022.
Published: 18 July 2013
... kinase (CASK) Ca 2+ /calmodulin-dependent kinase (CaMK) evolution intron membrane-associated guanylate kinase (MAGUK) phylogeny CASK (Ca 2+ /calmodulin-activated serine kinase), a peripheral plasma membrane protein, belongs to the MAGUK (membrane-associated guanylate kinase) family...
Articles
Biochem Soc Trans (2013) 41 (4): 876–880.
Published: 18 July 2013
... to enhance the activity of DICER on dsRNA substrates [ 5 , 6 ], whereas RDE-1 is the Argonaute responsible for binding primary siRNA [ 7 ]. Without RDE-1, primary siRNAs are still made, but they cannot be converted into secondary siRNAs [ 5 ]. evolution nematode parasite RNA interference (RNAi...
Articles
Biochem Soc Trans (2013) 41 (1): 362–367.
Published: 29 January 2013
... in all three domains of life, is the outcome of convergent evolution. 1 To whom correspondence should be addressed (email f.werner@ucl.ac.uk ). 23 10 2012 In summary, evolutionarily unrelated transcription initiation factors interact with a well-conserved motif of RNAP, the clamp...
Articles
Biochem Soc Trans (2013) 41 (1): 416–420.
Published: 29 January 2013
... by the newly found Nanoarchaeota and Korarchaeota. 1 email karl.stetter@biologie.uni-regensburg.de 26 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 Archaea Bacteria cultivation evolution phylogeny thermophile Table 1 Examples of genes...
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Biochem Soc Trans (2013) 41 (1): 458–462.
Published: 29 January 2013
.... 1 To whom correspondence should be addressed (email rwhitaker@life.illinois.edu ). 15 11 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 chromosomal marker exchange evolution recombination Sulfolobus islandicus Molecular Biology of Archaea...
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Biochem Soc Trans (2012) 40 (6): 1512–1516.
Published: 21 November 2012
... correspondence should be addressed (email monica.abrudan@postgrad.manchester.ac.uk ). 22 8 2012 © 2012 The Authors Journal 2012 bacteriocin biodiversity evolution quorum sensing signalling Recent theoretical and experimental work suggests that bacteriocins might play a key role...
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Biochem Soc Trans (2012) 40 (5): 1032–1037.
Published: 19 September 2012
... be addressed to either of these authors (email nsdgroot@mrc-lmb.cam.ac.uk or madanm@mrc-lmb.cam.ac.uk ). 10 7 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 amyloid chaperone evolution protein aggregation Figure 1 Scenarios favouring or disfavouring...
Articles
Biochem Soc Trans (2011) 39 (5): 1398–1402.
Published: 21 September 2011
... to proteins containing the motif of Kunitz-type protease inhibitors. Here, we discuss the evolution of genes encoding SCPs and describe mechanisms by which they and genes with Kunitz motifs might have evolved from genes with WFDC motifs. We can also demonstrate an expansion of the WFDC locus with 0.6 Mb...
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Biochem Soc Trans (2010) 38 (5): 1206–1209.
Published: 24 September 2010
...Igor Goryanin Modelling and optimization principles become a key concept in many biological areas, especially in biochemistry. Definitions of objective function, fitness and co-evolution, although they differ between biology and mathematics, are similar in a general sense. Although successful...
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Articles
Biochem Soc Trans (2010) 38 (3): 783–788.
Published: 24 May 2010
... has remained elusive. Plastids evolved by endosymbiosis and during the establishment of a permanent endosymbiosis they retained elements of the bacterial cell-division machinery. Through evolution the photosynthetic eukaryotes have increased dramatically in complexity, from single-cell green algae...
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Biochem Soc Trans (2010) 38 (2): 422–427.
Published: 22 March 2010
..., Israel. 5 To whom correspondence should be addressed (email Ada.Yonath@weizmann.ac.il ) 16 8 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 evolution Mycobacterium smegmatis proto-ribosome ribosome symmetrical region The ribosome...
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Biochem Soc Trans (2009) 37 (4): 787–791.
Published: 22 July 2009
... (Qa, Qb, Qc and R), each reflecting their position in the four-helix bundle. Further refinement of these main types resulted in the identification of 20 distinct conserved groups, which probably reflect the original repertoire of a proto-eukaryotic cell. We analysed the evolution of the SNARE...
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Biochem Soc Trans (2009) 37 (4): 792–795.
Published: 22 July 2009
...John W. Whitaker; Glenn A. McConkey; David R. Westhead HGT (horizontal gene transfer) is recognized as an important force in bacterial evolution. Now that many eukaryotic genomes have been sequenced, it has become possible to carry out studies of HGT in eukaryotes. The present review compares...
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Biochem Soc Trans (2009) 37 (4): 796–803.
Published: 22 July 2009
...Anthony J. Baines Spectrin is a cytoskeletal protein thought to have descended from an α-actinin-like ancestor. It emerged during evolution of animals to promote integration of cells into tissues by assembling signalling and cell adhesion complexes, by enhancing the mechanical stability...
Articles
Biochem Soc Trans (2009) 37 (3): 561–568.
Published: 20 May 2009
... of the evolution of this mode of AID regulation and the potential roles that it may play in activated B-cells during a normal immune response. 1 To whom correspondence should be addressed (email alt@enders.tch.harvard.edu ). 7 1 2009 © The Authors Journal compilation © 2009 Biochemical Society...
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Biochem Soc Trans (2009) 37 (1): 12–17.
Published: 20 January 2009
... the molecular mechanisms of transcription. 1 To whom correspondence should be addressed (email werner@biochem.ucl.ac.uk ). archaeon evolution RNA polymerase transcription The structure and function of RNAP ancestors in the deep and distant past of the ‘RNA world’ is subject to much...
Articles
Biochem Soc Trans (2008) 36 (6): 1359–1367.
Published: 19 November 2008
... isoforms, both known and novel; our findings suggest that substantial reassessment is required. actin calmin dystrophin evolution nesprin spectrin synaptic nuclear envelope protein (SYNE) We set out to see whether this applied to the nesprins. First, we examined the previously reported...
Includes: Supplementary data
Articles
Biochem Soc Trans (2008) 36 (3): 502–504.
Published: 21 May 2008
... The Authors Journal compilation © 2008 Biochemical Society 2008 alternative polyadenylation alternative splicing embryonic lethal abnormal visual system (ELAV) erect wing gene ( ewg gene) evolution nervous system development ELAV (embryonic lethal abnormal visual system) from Drosophila...
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Biochem Soc Trans (2007) 35 (5): 1317–1320.
Published: 25 October 2007
... of mycobacteria have undergone evolution by deletion of segments of DNA, allowing Mycobacterium bovis and other species to emerge from the M. tuberculosis complex, disproving the previously accepted theories. Deletions also affect the pathogenic potential of different lineages of M. tuberculosis . Over shorter...
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Biochem Soc Trans (2006) 34 (6): 1252–1255.
Published: 25 October 2006
... the evolution of the CYP (cytochrome P450) superfamily in insects can be proposed. There are four large clades of insect P450 genes that existed before the divergence of the class Insecta and that are also represented by CYP families in vertebrates: the CYP2 clade, the CYP3 clade, the CYP4 clade...
Articles
Biochem Soc Trans (2006) 34 (4): 569–573.
Published: 21 July 2006
...H.S. Malik; J.J. Bayes Centromeric DNA evolves rapidly, ranging in size and complexity over several orders of magnitude. Traditional attempts at studying centromeres have left unexplained the causes underlying this complexity and rapid evolution. Instead of directly studying centromeric DNA...
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Biochem Soc Trans (2006) 34 (4): 526–530.
Published: 21 July 2006
... and chimpanzees demonstrates very high rates of evolution of the fine-scale structure of the recombination landscape. In the light of these observations, we suggest possible resolutions of the hotspot paradox. evolution hotspot human genome meiosis recombination What is the solution? One...
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Biochem Soc Trans (2005) 33 (4): 780–784.
Published: 01 August 2005
... riboflavin synthase appear to have diverged early in the evolution of Archaea from a common ancestor. 1 To whom correspondence should be addressed (email markus.fischer@ch.tum.de ). 12 4 2005 © 2005 The Biochemical Society 2005 archaea eubacteria evolution reaction mechanism...
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Biochem Soc Trans (2005) 33 (1): 47–50.
Published: 01 February 2005
... of the various hydrogenosomes and their hydrogenases will contribute to an understanding of the evolution of the eukaryotic cell, and provide clues to the evolutionary origin(s) of the Fe-hydrogenase. Given the enormous diversity of hosts with hydrogenosomes in so many unrelated taxa, it is obvious...
Articles
Biochem Soc Trans (2003) 31 (3): 674–676.
Published: 01 June 2003
... held at The University of Nottingham, 30–31 January 2003 31 January 2003 © 2003 Biochemical Society 2003 Archaea evolution lagging strand proliferating cell nuclear antigen (PCNA) replication Abbreviations used: MCM, mini-chromosome maintenance; ORC, origin...
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Biochem Soc Trans (2003) 31 (3): 677–680.
Published: 01 June 2003
... in evolutionary time. Molecular Mechanisms and Manipulation in Archaea, a Biochemical Society-sponsored meeting held at The University of Nottingham, 30–31 January 2003 4 February 2003 © 2003 Biochemical Society 2003 calorimetry evolution halophile molecular recognition salt dependence...
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Biochem Soc Trans (2003) 31 (3): 563–571.
Published: 01 June 2003
... structures of the four Escherichia coli enzymes involved in the production of pantothenate have been determined. We describe the use of comparative analyses of the sequences and structures to identify distant homologues of the four enzymes in an attempt to understand the evolution of the pathway. We conclude...