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Articles

Differential functions of the KRAS splice variants

Juan Kochen Rossi, Cristina Nuevo-Tapioles, Mark R. Philips

Biochem Soc Trans (2023) 51 (3): 1191–1199.

https://doi.org/10.1042/BST20221347

Published: 24 May 2023

... alternative splicing evolution KRAS KRAS4A KRAS4B oncogene The human genome contains three RAS genes ( HRAS , KRAS , and NRAS ) that encode four RAS proteins (HRAS, KRAS4A, KRAS4B, and NRAS) [ 1 ]. RAS proteins are small, membrane-associated GTPases that act as molecular switches...

View article titled, Differential functions of the KRAS splice variants

Articles

How neural stem cells contribute to neocortex development

Lei Xing, Michaela Wilsch-Bräuninger, Wieland B. Huttner

Biochem Soc Trans (2021) 49 (5): 1997–2006.

https://doi.org/10.1042/BST20200923

Published: 16 August 2021

... for neurodevelopmental and psychiatric disorders. Correspondence: Wieland B. Huttner ( huttner@mpi-cbg.de ) 9 4 2021 15 7 2021 29 7 2021 cell proliferation evolution neocortex development neural progenitor cells neurogenesis The neocortex is the largest part of the mammalian...

View article titled, How neural stem cells contribute to neocortex development

Articles

Siblings or doppelgängers? Deciphering the evolution of structured cis-regulatory RNAs beyond homology

Elizabeth C. Gray, Daniel M. Beringer, Michelle M. Meyer

Biochem Soc Trans (2020) 48 (5): 1941–1951.

https://doi.org/10.1042/BST20191060

Published: 01 September 2020

..., similar functions may be obscured by lack of obvious sequence similarity. Thus looking beyond homology is crucial for furthering our understanding of RNA-based regulation. cis-regulator evolution homology RNA © 2020 The Author(s) 2020 This is an open access article published by Portland...

View article titled, Siblings or doppelgängers? Deciphering the evolution of structured cis-regulatory RNAs beyond homology

Articles

The fitness challenge of studying molecular adaptation

David Coombes, James W.B. Moir, Anthony M. Poole, Tim F. Cooper, Renwick C.J. Dobson

Biochem Soc Trans (2019) 47 (5): 1533–1542.

https://doi.org/10.1042/BST20180626

Published: 23 October 2019

... Limited on behalf of the Biochemical Society 2019 2 8 2019 30 9 2019 2 10 2019 Correspondence: Renwick Dobson ( renwick.dobson@canterbury.ac.nz ) evolution fitness molecular adaptation protein evolution It is common to assume natural selection as the ultimate...

View article titled, The fitness challenge of studying molecular adaptation

Articles

An updated structural classification of replicative DNA polymerases

Pierre Raia, Marc Delarue, Ludovic Sauguet

Biochem Soc Trans (2019) 47 (1): 239–249.

https://doi.org/10.1042/BST20180579

Published: 15 January 2019

... by Portland Press Limited on behalf of the Biochemical Society 2019 classification DNA polymerases DNA replication evolution PolD proofreading DNA replication is one of the most important functions in living organisms and viruses. It ensures the integrity of the genome and the accurate...

View article titled, An updated structural classification of replicative DNA polymerases

Articles

Structure of the plant photosystem I

Ido Caspy, Nathan Nelson

Biochem Soc Trans (2018) 46 (2): 285–294.

https://doi.org/10.1042/BST20170299

Published: 27 February 2018

...). Published by Portland Press Limited on behalf of the Biochemical Society 2018 evolution light-harvesting complexes membrane complexes photosynthesis photosystems structure The photochemical functions of oxygenic photosynthesis are performed by two photosystems, designated photosystem I...

View article titled, Structure of the plant photosystem I

Articles

Phosphate, inositol and polyphosphates

Thomas M. Livermore, Cristina Azevedo, Bernadett Kolozsvari, Miranda S.C. Wilson, Adolfo Saiardi

Biochem Soc Trans (2016) 44 (1): 253–259.

https://doi.org/10.1042/BST20150215

Published: 09 February 2016

..., inositol phosphates and polyP, speculating on the evolution of these relationships. 1 To whom correspondence should be addressed (email dmcbado@ucl.ac.uk ). 25 11 2015 © 2016 Authors; published by Portland Press Limited 2016 PolyP is the simplest biological polymer...

View article titled, Phosphate, inositol and polyphosphates

Articles

Modelling metabolic evolution on phenotypic fitness landscapes: a case study on C 4 photosynthesis

David Heckmann

Biochem Soc Trans (2015) 43 (6): 1172–1176.

https://doi.org/10.1042/BST20150148

Published: 27 November 2015

...David Heckmann How did the complex metabolic systems we observe today evolve through adaptive evolution? The fitness landscape is the theoretical framework to answer this question. Since experimental data on natural fitness landscapes is scarce, computational models are a valuable tool to predict...

View article titled, Modelling metabolic evolution on phenotypic fitness landscapes: a case study on C 4 photosynthesis

Articles

The substrate-binding protein in bacterial ABC transporters: dissecting roles in the evolution of substrate specificity

Abbas Maqbool, Richard S.P. Horler, Axel Muller, Anthony J. Wilkinson, Keith S. Wilson, Gavin H. Thomas

Biochem Soc Trans (2015) 43 (5): 1011–1017.

https://doi.org/10.1042/BST20150135

Published: 09 October 2015

... adenosine 5′-triphosphate-binding cassette (ABC) transporter evolution substrate-binding protein (SBP) substrate specificity ATP-binding cassette (ABC) transporters are ubiquitous in bacteria and function predominantly in substrate uptake as opposed to efflux. A common feature of these uptake...

View article titled, The substrate-binding protein in bacterial ABC transporters: dissecting roles in the evolution of substrate specificity

Articles

Structural biology of moonlighting: lessons from antibodies

Andrew C.R. Martin

Biochem Soc Trans (2014) 42 (6): 1704–1708.

https://doi.org/10.1042/BST20140211

Published: 17 November 2014

... compilation © 2014 Biochemical Society 2014 antibodies complementarity determining regions evolution moonlighting protein structure The traditional dogma of biology has been that DNA is copied into RNA which encodes a protein with a single function. Over the last 10–15 years, this dogma has...

View article titled, Structural biology of moonlighting: lessons from antibodies

Articles

Evolution of moonlighting proteins: insight from yeasts

Carlos Gancedo, Carmen-Lisset Flores, Juana M. Gancedo

Biochem Soc Trans (2014) 42 (6): 1715–1719.

https://doi.org/10.1042/BST20140199

Published: 17 November 2014

...Carlos Gancedo; Carmen-Lisset Flores; Juana M. Gancedo The present article addresses the possibilities offered by yeasts to study the problem of the evolution of moonlighting proteins. It focuses on data available on hexokinase from Saccharomyces cerevisiae that moonlights in catabolite repression...

View article titled, Evolution of moonlighting proteins: insight from yeasts

Articles

An evolutionary perspective on protein moonlighting

Shelley D. Copley

Biochem Soc Trans (2014) 42 (6): 1684–1691.

https://doi.org/10.1042/BST20140245

Published: 17 November 2014

... an inefficient function in one or the other of the copies [ 22 ]. adaptive conflict bifunctional protein evolution gene duplication moonlighting One of the primary determinants of the consequence of a mutation is a protein's stability. Since many amino acid changes are destabilizing [ 27 , 28...

View article titled, An evolutionary perspective on protein moonlighting

Articles

The RNA world and the origin of metabolic enzymes

Markus Ralser

Biochem Soc Trans (2014) 42 (4): 985–988.

https://doi.org/10.1042/BST20140132

Published: 11 August 2014

... and reproduction in any medium, provided the original work is properly cited. catalysis evolution glycolysis origin of life origin of metabolism pentose phosphate pathway replicator RNA We are far from understanding the origin of life, as several of the problems associated with it are yet...

View article titled, The RNA world and the origin of metabolic enzymes

Articles

Mechanisms underlying vertebrate limb regeneration: lessons from the salamander

Jeremy P. Brockes, Phillip B. Gates

Biochem Soc Trans (2014) 42 (3): 625–630.

https://doi.org/10.1042/BST20140002

Published: 22 May 2014

... in the mechanism of regeneration provides evidence for the importance of local evolution, rather than a purely ancestral mechanism. The three-finger protein called Prod1 is discussed in the present article as an exemplar of this approach. © The Authors Journal compilation © 2014 Biochemical Society 2014...

View article titled, Mechanisms underlying vertebrate limb regeneration: lessons from the salamander

Articles

Glyoxalase diversity in parasitic protists

Marcel Deponte

Biochem Soc Trans (2014) 42 (2): 473–478.

https://doi.org/10.1042/BST20140005

Published: 20 March 2014

... relationships have also been obtained from parasitic protists. These organisms, including kinetoplastid and apicomplexan parasites, are particularly interesting, both because of their relevance as pathogens and because of their phylogenetic diversity and host–parasite co-evolution which has led to specialized...

View article titled, Glyoxalase diversity in parasitic protists

Articles

The cAMP-binding Popdc proteins have a redundant function in the heart

Thomas Brand, Subreena L. Simrick, Kar Lai Poon, Roland F.R. Schindler

Biochem Soc Trans (2014) 42 (2): 295–301.

https://doi.org/10.1042/BST20130264

Published: 20 March 2014

... distributed under the terms of the Creative Commons Attribution Licence (CC-BY) ( http://creativecommons.org/licenses/by/3.0/ ) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. cAMP cardiac arrhythmia caveolin 3 evolution...

View article titled, The cAMP-binding Popdc proteins have a redundant function in the heart

Articles

Genomic impact of CRISPR immunization against bacteriophages

Rodolphe Barrangou, Anne-Claire Coûté-Monvoisin, Buffy Stahl, Isabelle Chavichvily, Florian Damange, Dennis A. Romero, Patrick Boyaval, Christophe Fremaux, Philippe Horvath

Biochem Soc Trans (2013) 41 (6): 1383–1391.

https://doi.org/10.1042/BST20130160

Published: 20 November 2013

... (Cas) system draft genome evolution © The Authors Journal compilation © 2013 Biochemical Society 2013 CRISPR loci, together with cas genes form the CRISPR–Cas immune system, which is present in ~46% of bacteria and almost 90% of archaea [ 17 , 18 ]. CRISPR loci typically consist...

View article titled, Genomic impact of CRISPR immunization against bacteriophages

Articles

Alu elements: at the crossroads between disease and evolution

Jernej Ule

Biochem Soc Trans (2013) 41 (6): 1532–1535.

https://doi.org/10.1042/BST20130157

Published: 20 November 2013

... in the inclusion of Alu exon into mature transcripts. Moreover, I present the mechanism that represses such a major inclusion of Alu exons and instead enables a gradual evolution of Alu elements into new exons. 1 email j.ule@ucl.ac.uk 13 8 2013 Alu elements are retrotransposable elements...

View article titled, Alu elements: at the crossroads between disease and evolution

Articles

The basic building blocks and evolution of CRISPR–Cas systems

Kira S. Makarova, Yuri I. Wolf, Eugene V. Koonin

Biochem Soc Trans (2013) 41 (6): 1392–1400.

https://doi.org/10.1042/BST20130038

Published: 20 November 2013

... homologous with viral or plasmid DNA and integrated into the CRISPR loci. Most of the Cas proteins evolve under relaxed purifying selection and some underwent dramatic structural rearrangements during evolution. In many cases, CRISPR–Cas system components are replaced either by homologous or by analogous...

View article titled, The basic building blocks and evolution of CRISPR–Cas systems

Includes: Supplementary data

Articles

Engineering chimaeric proteins from fold fragments: ‘hopeful monsters’ in protein design

Birte Höcker

Biochem Soc Trans (2013) 41 (5): 1137–1140.

https://doi.org/10.1042/BST20130099

Published: 23 September 2013

... email birte.hoecker@tuebingen.mpg.de 5 6 2013 © 2013 The Authors 2013 (βα) 8 -barrel computational design evolution flavodoxin-like fold fold fragments protein chimaera The ubiquitous (βα) 8 -barrel, which is a typical enzyme fold, has been hypothesized to have evolved...

View article titled, Engineering chimaeric proteins from fold fragments: ‘hopeful monsters’ in protein design

Articles

Structural constraints and functional divergences in CASK evolution

Leslie LaConte, Konark Mukherjee

Biochem Soc Trans (2013) 41 (4): 1017–1022.

https://doi.org/10.1042/BST20130061

Published: 18 July 2013

... kinase (CASK) Ca 2+ /calmodulin-dependent kinase (CaMK) evolution intron membrane-associated guanylate kinase (MAGUK) phylogeny CASK (Ca 2+ /calmodulin-activated serine kinase), a peripheral plasma membrane protein, belongs to the MAGUK (membrane-associated guanylate kinase) family...

View article titled, Structural constraints and functional divergences in CASK evolution

Articles

RNAi pathways in the recognition of foreign RNA: antiviral responses and host–parasite interactions in nematodes

Peter Sarkies, Eric A. Miska

Biochem Soc Trans (2013) 41 (4): 876–880.

https://doi.org/10.1042/BST20130021

Published: 18 July 2013

... to enhance the activity of DICER on dsRNA substrates [ 5 , 6 ], whereas RDE-1 is the Argonaute responsible for binding primary siRNA [ 7 ]. Without RDE-1, primary siRNAs are still made, but they cannot be converted into secondary siRNAs [ 5 ]. evolution nematode parasite RNA interference (RNAi...

View article titled, RNAi pathways in the recognition of foreign RNA: antiviral responses and host–parasite interactions in nematodes

Articles

Archaeology of RNA polymerase: factor swapping during the transcription cycle

Fabian Blombach, Tina Daviter, Daniel Fielden, Dina Grohmann, Katherine Smollett, Finn Werner

Biochem Soc Trans (2013) 41 (1): 362–367.

https://doi.org/10.1042/BST20120274

Published: 29 January 2013

... in all three domains of life, is the outcome of convergent evolution. 1 To whom correspondence should be addressed (email f.werner@ucl.ac.uk ). 23 10 2012 In summary, evolutionarily unrelated transcription initiation factors interact with a well-conserved motif of RNAP, the clamp...

View article titled, Archaeology of RNA polymerase: factor swapping during the transcription cycle

Articles

A brief history of the discovery of hyperthermophilic life

Karl O. Stetter

Biochem Soc Trans (2013) 41 (1): 416–420.

https://doi.org/10.1042/BST20120284

Published: 29 January 2013

... by the newly found Nanoarchaeota and Korarchaeota. 1 email karl.stetter@biologie.uni-regensburg.de 26 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 Archaea Bacteria cultivation evolution phylogeny thermophile Table 1 Examples of genes...

View article titled, A brief history of the discovery of hyperthermophilic life

Articles

Sulfolobus islandicus: a model system for evolutionary genomics

Changyi Zhang, David J. Krause, Rachel J. Whitaker

Biochem Soc Trans (2013) 41 (1): 458–462.

https://doi.org/10.1042/BST20120338

Published: 29 January 2013

.... 1 To whom correspondence should be addressed (email rwhitaker@life.illinois.edu ). 15 11 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 chromosomal marker exchange evolution recombination Sulfolobus islandicus Molecular Biology of Archaea...

View article titled, Sulfolobus islandicus: a model system for evolutionary genomics

Articles

Killing as means of promoting biodiversity

Monica I. Abrudan, Sarah Brown, Daniel E. Rozen

Biochem Soc Trans (2012) 40 (6): 1512–1516.

https://doi.org/10.1042/BST20120196

Published: 21 November 2012

... correspondence should be addressed (email monica.abrudan@postgrad.manchester.ac.uk ). 22 8 2012 © 2012 The Authors Journal 2012 bacteriocin biodiversity evolution quorum sensing signalling Recent theoretical and experimental work suggests that bacteriocins might play a key role...

View article titled, Killing as means of promoting biodiversity

Articles

Evolutionary selection for protein aggregation

Natalia Sanchez de Groot, Marc Torrent, Anna Villar-Piqué, Benjamin Lang, Salvador Ventura, Jörg Gsponer, M. Madan Babu

Biochem Soc Trans (2012) 40 (5): 1032–1037.

https://doi.org/10.1042/BST20120160

Published: 19 September 2012

... be addressed to either of these authors (email nsdgroot@mrc-lmb.cam.ac.uk or madanm@mrc-lmb.cam.ac.uk ). 10 7 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 amyloid chaperone evolution protein aggregation Figure 1 Scenarios favouring or disfavouring...

View article titled, Evolutionary selection for protein aggregation

Articles

Genes encoding WFDC- and Kunitz-type protease inhibitor domains: are they related?

Åke Lundwall, Adam Clauss

Biochem Soc Trans (2011) 39 (5): 1398–1402.

https://doi.org/10.1042/BST0391398

Published: 21 September 2011

... to proteins containing the motif of Kunitz-type protease inhibitors. Here, we discuss the evolution of genes encoding SCPs and describe mechanisms by which they and genes with Kunitz motifs might have evolved from genes with WFDC motifs. We can also demonstrate an expansion of the WFDC locus with 0.6 Mb...

View article titled, Genes encoding WFDC- and Kunitz-type protease inhibitor domains: are they related?

Articles

Computational optimization and biological evolution

Igor Goryanin

Biochem Soc Trans (2010) 38 (5): 1206–1209.

https://doi.org/10.1042/BST0381206

Published: 24 September 2010

...Igor Goryanin Modelling and optimization principles become a key concept in many biological areas, especially in biochemistry. Definitions of objective function, fitness and co-evolution, although they differ between biology and mathematics, are similar in a general sense. Although successful...

View article titled, Computational optimization and biological evolution

Articles

The principle of sufficiency and the evolution of control: using control analysis to understand the design principles of biological systems

Guy C. Brown

Biochem Soc Trans (2010) 38 (5): 1210–1214.

https://doi.org/10.1042/BST0381210

Published: 24 September 2010

... the constraint of minimizing space utilization. For any biological process with multiple steps that compete for control in series, evolution by natural selection will tend to even out the control exerted by each step. This is for two reasons: (i) shared control maximizes the flux for minimum protein...

View article titled, The principle of sufficiency and the evolution of control: using control analysis to understand the design principles of biological systems

Articles

The complexity and evolution of the plastid-division machinery

Jodi Maple, Simon Geir Møller

Biochem Soc Trans (2010) 38 (3): 783–788.

https://doi.org/10.1042/BST0380783

Published: 24 May 2010

... has remained elusive. Plastids evolved by endosymbiosis and during the establishment of a permanent endosymbiosis they retained elements of the bacterial cell-division machinery. Through evolution the photosynthetic eukaryotes have increased dramatically in complexity, from single-cell green algae...

View article titled, The complexity and evolution of the plastid-division machinery

Articles

Ancient machinery embedded in the contemporary ribosome

Matthew J. Belousoff, Chen Davidovich, Ella Zimmerman, Yaron Caspi, Itai Wekselman, Lin Rozenszajn, Tal Shapira, Ofir Sade-Falk, Leena Taha, Anat Bashan, Manfred S. Weiss, Ada Yonath

Biochem Soc Trans (2010) 38 (2): 422–427.

https://doi.org/10.1042/BST0380422

Published: 22 March 2010

..., Israel. 5 To whom correspondence should be addressed (email Ada.Yonath@weizmann.ac.il ) 16 8 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 evolution Mycobacterium smegmatis proto-ribosome ribosome symmetrical region The ribosome...

View article titled, Ancient machinery embedded in the contemporary ribosome

Articles

Differences in the SNARE evolution of fungi and metazoa

Nickias Kienle, Tobias H. Kloepper, Dirk Fasshauer

Biochem Soc Trans (2009) 37 (4): 787–791.

https://doi.org/10.1042/BST0370787

Published: 22 July 2009

... (Qa, Qb, Qc and R), each reflecting their position in the four-helix bundle. Further refinement of these main types resulted in the identification of 20 distinct conserved groups, which probably reflect the original repertoire of a proto-eukaryotic cell. We analysed the evolution of the SNARE...

View article titled, Differences in the SNARE evolution of fungi and metazoa

Articles

Prediction of horizontal gene transfers in eukaryotes: approaches and challenges

John W. Whitaker, Glenn A. McConkey, David R. Westhead

Biochem Soc Trans (2009) 37 (4): 792–795.

https://doi.org/10.1042/BST0370792

Published: 22 July 2009

...John W. Whitaker; Glenn A. McConkey; David R. Westhead HGT (horizontal gene transfer) is recognized as an important force in bacterial evolution. Now that many eukaryotic genomes have been sequenced, it has become possible to carry out studies of HGT in eukaryotes. The present review compares...

View article titled, Prediction of horizontal gene transfers in eukaryotes: approaches and challenges

Articles

Evolution of spectrin function in cytoskeletal and membrane networks

Anthony J. Baines

Biochem Soc Trans (2009) 37 (4): 796–803.

https://doi.org/10.1042/BST0370796

Published: 22 July 2009

...Anthony J. Baines Spectrin is a cytoskeletal protein thought to have descended from an α-actinin-like ancestor. It emerged during evolution of animals to promote integration of cells into tissues by assembling signalling and cell adhesion complexes, by enhancing the mechanical stability...

View article titled, Evolution of spectrin function in cytoskeletal and membrane networks

Articles

Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser 38 phosphorylation

Uttiya Basu, Andrew Franklin, Bjoern Schwer, Hwei-Ling Cheng, Jayanta Chaudhuri, Frederick W. Alt

Biochem Soc Trans (2009) 37 (3): 561–568.

https://doi.org/10.1042/BST0370561

Published: 20 May 2009

... of the evolution of this mode of AID regulation and the potential roles that it may play in activated B-cells during a normal immune response. 1 To whom correspondence should be addressed (email alt@enders.tch.harvard.edu ). 7 1 2009 © The Authors Journal compilation © 2009 Biochemical Society...

View article titled, Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser 38 phosphorylation

Articles

Molecular mechanisms of archaeal RNA polymerase

Dina Grohmann, Angela Hirtreiter, Finn Werner

Biochem Soc Trans (2009) 37 (1): 12–17.

https://doi.org/10.1042/BST0370012

Published: 20 January 2009

... the molecular mechanisms of transcription. 1 To whom correspondence should be addressed (email werner@biochem.ucl.ac.uk ). archaeon evolution RNA polymerase transcription The structure and function of RNAP ancestors in the deep and distant past of the ‘RNA world’ is subject to much...

View article titled, Molecular mechanisms of archaeal RNA polymerase

Articles

Patterns of evolutionary conservation in the nesprin genes highlight probable functionally important protein domains and isoforms

Jennifer G. Simpson, Roland G. Roberts

Biochem Soc Trans (2008) 36 (6): 1359–1367.

https://doi.org/10.1042/BST0361359

Published: 19 November 2008

... isoforms, both known and novel; our findings suggest that substantial reassessment is required. actin calmin dystrophin evolution nesprin spectrin synaptic nuclear envelope protein (SYNE) We set out to see whether this applied to the nesprins. First, we examined the previously reported...

View article titled, Patterns of evolutionary conservation in the nesprin genes highlight probable functionally important protein domains and isoforms

Includes: Supplementary data

Articles

Regulation of the ELAV target ewg : insights from an evolutionary perspective

Matthias Soller, Min Li, Irmgard U. Haussmann

Biochem Soc Trans (2008) 36 (3): 502–504.

https://doi.org/10.1042/BST0360502

Published: 21 May 2008

... The Authors Journal compilation © 2008 Biochemical Society 2008 alternative polyadenylation alternative splicing embryonic lethal abnormal visual system (ELAV) erect wing gene ( ewg gene) evolution nervous system development ELAV (embryonic lethal abnormal visual system) from Drosophila...

View article titled, Regulation of the ELAV target ewg : insights from an evolutionary perspective

Articles

Tuberculosis: evolution in millennia and minutes

S.H. Gillespie

Biochem Soc Trans (2007) 35 (5): 1317–1320.

https://doi.org/10.1042/BST0351317

Published: 25 October 2007

... of mycobacteria have undergone evolution by deletion of segments of DNA, allowing Mycobacterium bovis and other species to emerge from the M. tuberculosis complex, disproving the previously accepted theories. Deletions also affect the pathogenic potential of different lineages of M. tuberculosis . Over shorter...

View article titled, Tuberculosis: evolution in millennia and minutes

Articles

Evolution of insect P450

R. Feyereisen

Biochem Soc Trans (2006) 34 (6): 1252–1255.

https://doi.org/10.1042/BST0341252

Published: 25 October 2006

... the evolution of the CYP (cytochrome P450) superfamily in insects can be proposed. There are four large clades of insect P450 genes that existed before the divergence of the class Insecta and that are also represented by CYP families in vertebrates: the CYP2 clade, the CYP3 clade, the CYP4 clade...

View article titled, Evolution of insect P450

Articles

Genetic conflicts during meiosis and the evolutionary origins of centromere complexity

H.S. Malik, J.J. Bayes

Biochem Soc Trans (2006) 34 (4): 569–573.

https://doi.org/10.1042/BST0340569

Published: 21 July 2006

...H.S. Malik; J.J. Bayes Centromeric DNA evolves rapidly, ranging in size and complexity over several orders of magnitude. Traditional attempts at studying centromeres have left unexplained the causes underlying this complexity and rapid evolution. Instead of directly studying centromeric DNA...

View article titled, Genetic conflicts during meiosis and the evolutionary origins of centromere complexity

Articles

The distribution and causes of meiotic recombination in the human genome

S. Myers, C.C.A. Spencer, A. Auton, L. Bottolo, C. Freeman, P. Donnelly, G. McVean

Biochem Soc Trans (2006) 34 (4): 526–530.

https://doi.org/10.1042/BST0340526

Published: 21 July 2006

... and chimpanzees demonstrates very high rates of evolution of the fine-scale structure of the recombination landscape. In the light of these observations, we suggest possible resolutions of the hotspot paradox. evolution hotspot human genome meiosis recombination What is the solution? One...

View article titled, The distribution and causes of meiotic recombination in the human genome

Articles

Structures and reaction mechanisms of riboflavin synthases of eubacterial and archaeal origin

M. Fischer, W. Römisch, B. Illarionov, W. Eisenreich, A. Bacher

Biochem Soc Trans (2005) 33 (4): 780–784.

https://doi.org/10.1042/BST0330780

Published: 01 August 2005

... riboflavin synthase appear to have diverged early in the evolution of Archaea from a common ancestor. 1 To whom correspondence should be addressed (email markus.fischer@ch.tum.de ). 12 4 2005 © 2005 The Biochemical Society 2005 archaea eubacteria evolution reaction mechanism...

View article titled, Structures and reaction mechanisms of riboflavin synthases of eubacterial and archaeal origin

Articles

Evolution of the bacterial phosphotransferase system: from carriers and enzymes to group translocators

M.H. Saier, Jr, R.N. Hvorup, R.D. Barabote

Biochem Soc Trans (2005) 33 (1): 220–224.

https://doi.org/10.1042/BST0330220

Published: 01 February 2005

.... The work described provides detailed insight into the process of catalytic protein evolution. 1 To whom correspondence should be addressed (email msaier@ucsd.edu ). 7 10 2004 © 2005 The Biochemical Society 2005 energy coupling evolution phosphotransferase system secondary...

View article titled, Evolution of the bacterial phosphotransferase system: from carriers and enzymes to group translocators

Articles

Eukaryotic Fe-hydrogenases – old eukaryotic heritage or adaptive acquisitions?

J.H.P. Hackstein

Biochem Soc Trans (2005) 33 (1): 47–50.

https://doi.org/10.1042/BST0330047

Published: 01 February 2005

... of the various hydrogenosomes and their hydrogenases will contribute to an understanding of the evolution of the eukaryotic cell, and provide clues to the evolutionary origin(s) of the Fe-hydrogenase. Given the enormous diversity of hosts with hydrogenosomes in so many unrelated taxa, it is obvious...

View article titled, Eukaryotic Fe-hydrogenases – old eukaryotic heritage or adaptive acquisitions?

Articles

DNA replication in the hyperthermophilic archaeon Sulfolobus solfataricus

I. Dionne, N.P. Robinson, A.T. McGeoch, V.L. Marsh, A. Reddish, S.D. Bell

Biochem Soc Trans (2003) 31 (3): 674–676.

https://doi.org/10.1042/bst0310674

Published: 01 June 2003

... held at The University of Nottingham, 30–31 January 2003 31 January 2003 © 2003 Biochemical Society 2003 Archaea evolution lagging strand proliferating cell nuclear antigen (PCNA) replication Abbreviations used: MCM, mini-chromosome maintenance; ORC, origin...

View article titled, DNA replication in the hyperthermophilic archaeon Sulfolobus solfataricus

Articles

Halophilic adaptation of protein–DNA interactions

S. Bergqvist, M.A. Williams, R. O'Brien, J.E. Ladbury

Biochem Soc Trans (2003) 31 (3): 677–680.

https://doi.org/10.1042/bst0310677

Published: 01 June 2003

... in evolutionary time. Molecular Mechanisms and Manipulation in Archaea, a Biochemical Society-sponsored meeting held at The University of Nottingham, 30–31 January 2003 4 February 2003 © 2003 Biochemical Society 2003 calorimetry evolution halophile molecular recognition salt dependence...

View article titled, Halophilic adaptation of protein–DNA interactions

Articles

Structural insights into the evolution of the pantothenate-biosynthesis pathway

C.M.C. Lobley, F. Schmitzberger, M.L. Kilkenny, H. Whitney, H.H. Ottenhof, E. Chakauya, M.E. Webb, L.M. Birch, K.L. Tuck, C. Abell, A.G. Smith, T.L. Blundell

Biochem Soc Trans (2003) 31 (3): 563–571.

https://doi.org/10.1042/bst0310563

Published: 01 June 2003

... structures of the four Escherichia coli enzymes involved in the production of pantothenate have been determined. We describe the use of comparative analyses of the sequences and structures to identify distant homologues of the four enzymes in an attempt to understand the evolution of the pathway. We conclude...

View article titled, Structural insights into the evolution of the pantothenate-biosynthesis pathway

Articles

Communication: from neurons to people; from present to future

S.P.R. Rose

Biochem Soc Trans (2003) 31 (1): 159–161.

https://doi.org/10.1042/bst0310159

Published: 01 February 2003

... e-mail s.p.r.rose@open.ac.uk Signalling the Future, a Biochemical Society-sponsored meeting held at University of Liverpool, Liverpool, 4–6 September 2002 6 September 2002 Copyright 2003 Biochemical Society 2003 evolution exaptation metaphors intercellular...

View article titled, Communication: from neurons to people; from present to future

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