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Keywords: eukaryotic initiation factor 4A (eIF4A)
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Biochem Soc Trans (2015) 43 (6): 1227–1233.
Published: 27 November 2015
... are translationally up-regulated. Such mRNAs have been shown to possess longer and more structured 5′-UTRs requiring high levels of eukaryotic initiation factor 4A (eIF4A) helicase activity for efficient translation. As such there is a developing focus on targeting eIF4A as a cancer therapy. In order...
Biochem Soc Trans (2014) 42 (1): 166–172.
Published: 23 January 2014
... Li W. Belsham G.J. Proud C.G. Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo J. Biol. Chem. 2001 276 29111 29115 51 Braun J.E. Huntzinger E. Fauser M. Izaurralde E. GW182 proteins directly recruit cytoplasmic...