... key for translational regulation. 1 To whom correspondence should be addressed (email nwortham@trafalgarschool.org.uk ). 24 7 2015 © 2015 Authors; published by Portland Press Limited 2015 eukaryotic initiation factor 2B (eIF2B) integrated stress response integrated...

... eukaryotic initiation factor 2B (eIF2B) protein synthesis vanishing white matter (VWM) eIF2B is controlled by several mechanisms, particularly in response to cellular stress in diverse organisms from yeast to humans. One well-studied and evolutionarily conserved mechanism is via phosphorylation...

...–GEF pairs and compare these with observations from our research on eIF2 and eIF2B to propose a model for how interactions between eIF2B and eIF2 promote guanine nucleotide exchange. childhood ataxia with central nervous system hypomyelination (CACH) eukaryotic initiation factor 2B (eIF2B) G...

... matter syndrome (CACH/VWM syndrome) eukaryotic initiation factor 2B (eIF2B) guanine nucleotide-exchange factor (GEF) leukodystrophy translation translation regulation Figure 2 Comparison of cerebral magnetic resonance imaging from subjects with and without CACH/VVM Cerebral MRI (Flair...

... studies of the yeast and mammalian eIF2B proteins. 1 email graham.pavitt@manchester.ac.uk 22 6 2005 © 2005 The Biochemical Society 2005 childhood ataxia with central nervous system hypomyelination/vanishing white matter (CACH/VWM) eukaryotic initiation factor 2B (eIF2B...