...D.P. Sullivan; H. Ohvo-Rekilä; N.A. Baumann; C.T. Beh; A.K. Menon We recently showed that transport of ergosterol from the ER (endoplasmic reticulum) to the sterol-enriched PM (plasma membrane) in yeast occurs by a non-vesicular (Sec18p-independent) mechanism that results in the equilibration...

... and for the promotion of good health. A large range of lipidic products produced by yeast is known today. Ergosterol and its metabolic precursors are major lipidic components of industrial and commercial interest. Having in mind the aim to increase the productivity of ergosterol and its precursor metabolites, both...

...R. Pasrija; T. Prasad; R. Prasad By exploiting the biosynthetic pathways of raft lipid constituents, in this study we demonstrate that fluctuations in either sphingolipid or ergosterol levels result in increased drug sensitivity and morphological defects in Candida albicans cells. We show that any...

... in relation to sterol and AdoMet substrates. The structure of SMT is predicted based on known crystallographic structures of AdoMet-dependent methyltransferase as reported in [ 38 ]. Term., terminal. enzyme redesign ergosterol phytosterol diversity site-directed mutagenesis sterol biosynthesis...