... seed the marrow are one of the essential requirements for T-cell production in the thymus and the other is the stromal cell elements which, as a minimum, must include epithelial cells and fibroblasts ( Figure 1 ). Figure 1 Thymic seeding The thymus is seeded throughout life by extrathymic T...

... on the role of different trafficking pathways in epithelial cell migration, including clathrin-mediated endocytosis, caveolar endocytosis, exocytosis of biosynthetic cargo, ‘short-loop’ and ‘long-loop’ endosomal recycling. 1 To whom any correspondence should be addressed (email J.rappaport@bham.ac.uk...

... to sphingosine derivatives. The detection of splice variants with probably different activation mechanisms supports the idea that TRPM3 may have diverse cellular functions depending on the expression of a particular variant. The expression of TRPV4 in many epithelial cell types raised the question of the role...

... as effector molecules of innate immunity. These peptides are mainly produced by phagocytes and epithelial cells, and kill a wide range of micro-organisms: Gram-negative and Gram-positive bacteria, fungi and (enveloped) viruses. However, it is increasingly evident that these peptides not only act as endogenous...

... and disassembly with high spatial resolution. Statistical processing of single speckle properties revealed two kinetically, kinematically and molecularly distinct, yet spatially overlapping, actin arrays at the leading edge of migrating epithelial cells. The first network, referred to as the lamellipodium...

... that, similar to Wnt signalling, LTD 4 increases free β-catenin and targets it to the nucleus. cancer β-catenin epithelial cell leukotriene D 4 TCF (T-cell factor)/LEF (lymphoid enhancer factor) LTD 4 (leukotriene D 4 ) is a pro-inflammatory mediator, that is known to mediate its effects...

... at University of Liverpool, Liverpool, 4–6 September 2002 8 October 2002 Copyright 2003 Biochemical Society 2003 acetylation asthma epithelial cell granulocyte/macrophage colony-stimulating factor (GM-CSF) inflammation Abbreviations used: AP-1, activating protein-1; CBP, cAMP...