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Keywords: epistasis
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Articles
Biochem Soc Trans (2017) 45 (6): 1253–1261.
Published: 20 October 2017
... structure prediction toward accuracies approaching the experimental resolution limit. Going beyond structure prediction, the same mathematical framework allows mimicking evolutionary fitness landscapes to infer signaling interactions, epistasis, or mutational landscapes. Correspondence: Alexander...
Articles
Biochem Soc Trans (2015) 43 (6): 1172–1176.
Published: 27 November 2015
... photosynthesis epistasis evolution fitness landscape genotype-phenotype map metabolic model The metabolism of multicellular organisms exhibits an outstanding complexity in both the number and the spatial arrangement of interacting components. Since many of those components appear to be essential...
Articles
Biochem Soc Trans (2006) 34 (4): 519–522.
Published: 21 July 2006
... quite difficult to identify conditions that favour the evolution of high rates of sex and recombination. For example, fitness interactions among genes (epistasis) can favour sex and recombination but only if such interactions are negative, relatively weak and not highly variable. One reason why...
Articles
Biochem Soc Trans (2006) 34 (4): 560–561.
Published: 21 July 2006
... to follow fitness gradients in two different spaces: in nucleotide sequence space and allele sequence space respectively. Epistasis for fitness at these two scales, between nucleotides and between genes, may be qualitatively different and may significantly influence the advantage of mutation-based...