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Keywords: epigenetic therapy
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Biochem Soc Trans (2004) 32 (6): 910–912.
Published: 26 October 2004
...C.B. Yoo; J.C. Cheng; P.A. Jones Regulatory genes are often hypermethylated at their promoter 5′ regions and silenced in cancer. Epigenetic therapy with DNA methylation inhibitors have been shown to result in the demethylation and reactivation of these genes. Zebularine is a recently discovered...