... (phosphoinositide 3-kinase) signalling upon treatment and how that affects drug sensitivity. drug response epidermal growth factor receptor (EGFR) feedback mathematical modelling mitogen-activated protein kinase (MAPK) signalling Aberrant signalling by the MAPK (mitogen-activated protein kinase...

...@cancer.org.uk ). 14 2 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 cancer drug resistance epidermal growth factor receptor (EGFR) human epidermal growth factor receptor 2 (HER2) human epidermal growth factor receptor 3 (HER3) kinase inhibition...

... the formation of EGFR complexes. 1 To whom correspondence should be addressed (email sarah.needham@stfc.ac.uk ). 7 10 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 cortical actin dimerization epidermal growth factor receptor (EGFR) oligomerization single...

... (email jeroen.claus@cancer.org.uk ). 3 5 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 cancer epidermal growth factor receptor (EGFR) kinase kinase inhibitor protein kinase A (PKA) pseudokinase The collection of all kinases in a cell, the kinome...

... endoplasmic reticulum (ER) endosomal sorting complex required for transport machinery (ESCRT machinery) epidermal growth factor receptor (EGFR) intraluminal vesicle (ILV) multivesicular endosome/body (MVB) protein tyrosine phosphatase 1B (PTP1B) Following EGF (epidermal growth factor)-induced...

... with the plasma membrane. 1 email marisa.martin-fernandez@stfc.ac.uk 4 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 epidermal growth factor receptor (EGFR) fluorescence lifetime imaging microscopy (FLIM) Förster resonance energy transfer (FRET) human...

... © 2012 Biochemical Society 2012 epidermal growth factor (EGF) epidermal growth factor receptor (EGFR) negative co-operativity saturation binding isotherm EGF (epidermal growth factor) was first purified from extracts of mouse submaxillary glands by Stanley Cohen nearly half...

.... 1 email aislyn.wist@mssm.edu 24 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 cancer epidermal growth factor receptor (EGFR) ErbB juxtamembrane domain receptor tyrosine kinase EGF (epidermal growth factor) and its corresponding receptor...

... factor receptor (EGFR) integrin tetraspanin Co-ordination of signals from different groups of transmembrane receptors is vital for normal development and maintenance of tissue homoeostasis, and de-regulation of this process may lead to the progression of many diseases, including cancer [ 1 – 5...

...) endosome epidermal growth factor receptor (EGFR) His domain phosphotyrosine phosphatase (HD-PTP) multivesicular body (MVB) Down-regulation of mitogenic tyrosine kinase receptors is a process of fundamental importance, since defective receptor down-regulation results in a failure to turn off...

... that either ESCRT-III is dispensable for EGF-stimulated intraluminal vesicle formation or that other ESCRT-III components can compensate for loss of VPS24. epidermal growth factor receptor (EGFR) endosomal sorting complex required for transport (ESCRT) multivesicular body (MVB) phosphoinositide 3...

... 2007 Biochemical Society 2007 aldosterone epidermal growth factor receptor (EGFR) epithelial sodium channel (ENaC) hypertension protein kinase C (PKC) protein kinase D (PKD) The mineralocorticoid hormone, aldosterone, is released into the circulation by the adrenal cortex as the final...

... © 2007 Biochemical Society 2007 breast cancer cell line drug response epidermal growth factor receptor (EGFR) three-dimensional extracellular matrix culture tumour necrosis factor α (TNFα) tumour necrosis factor α-converting enzyme (TACE) We have extensively studied a culture...

... 2007 The Biochemical Society 2007 diagnostics epidermal growth factor receptor (EGFR) growth factor signalling therapeutics This short review describes the work that I have been doing for the last 45 years on growth factors, their receptors and signal transduction mechanisms. When I...

...-chimaerin C1 domain diacylglycerol epidermal growth factor receptor (EGFR) phorbol ester phospholipase Cγ (PLCγ) Rac1 While the properties of chimaerins as phorbol ester receptors have been known for years, a crucial question that remained unanswered was whether chimaerins were responsive...

... of Sheffield, 21 July 2003 10 July 2003 © 2003 Biochemical Society 2003 epidermal growth factor receptor (EGFR) proteomics signal transduction small-molecule tyrosine kinase inhibitor surrogate marker two-dimensional electrophoresis Abbreviations used: SMTKI, small-molecule...

... (ADAM) cancer cross-talk epidermal growth factor receptor (EGFR) G-protein-coupled receptor (GPCR) transactivation Abbreviations used: ADAM, a d isintegrin a nd m etalloprotease; ET-1, endothelin-1; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; ERK...