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Keywords: epidermal growth factor receptor (EGFR)
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Articles
Biochem Soc Trans (2014) 42 (4): 770–775.
Published: 11 August 2014
... factor receptor (EGFR) feedback mathematical modelling mitogen-activated protein kinase (MAPK) signalling Aberrant signalling by the MAPK (mitogen-activated protein kinase) and PI3K (phosphoinositide 3-kinase) pathways drives many tumours. These pathways are often activated by mutations...
Articles
Biochem Soc Trans (2014) 42 (4): 831–836.
Published: 11 August 2014
...@cancer.org.uk ). 14 2 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 cancer drug resistance epidermal growth factor receptor (EGFR) human epidermal growth factor receptor 2 (HER2) human epidermal growth factor receptor 3 (HER3) kinase inhibition The EGFR...
Articles
Biochem Soc Trans (2014) 42 (1): 114–119.
Published: 23 January 2014
... the formation of EGFR complexes. 1 To whom correspondence should be addressed (email sarah.needham@stfc.ac.uk ). 7 10 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 cortical actin dimerization epidermal growth factor receptor (EGFR) oligomerization single...
Articles
Biochem Soc Trans (2013) 41 (4): 1083–1088.
Published: 18 July 2013
... of (pseudo)kinases and the dual potential impact on the druggability of these proteins. 1 To whom correspondence should be addressed (email jeroen.claus@cancer.org.uk ). 3 5 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 cancer epidermal growth factor...
Articles
Biochem Soc Trans (2012) 40 (2): 464–468.
Published: 21 March 2012
...) epidermal growth factor receptor (EGFR) intraluminal vesicle (ILV) multivesicular endosome/body (MVB) protein tyrosine phosphatase 1B (PTP1B) Clathrin-containing coats were identified on flattened domains of endosomes more than 10 years ago [ 6 ] and these domains were shown to contain Hrs...
Articles
Biochem Soc Trans (2012) 40 (1): 184–188.
Published: 19 January 2012
... with the plasma membrane. 1 email marisa.martin-fernandez@stfc.ac.uk 4 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 epidermal growth factor receptor (EGFR) fluorescence lifetime imaging microscopy (FLIM) Förster resonance energy transfer (FRET) human...
Articles
Biochem Soc Trans (2012) 40 (1): 15–19.
Published: 19 January 2012
... receptor is positively linked with dimer assembly, but shows negative co-operativity within the dimer. 1 email pike@biochem.wustl.edu 31 5 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 epidermal growth factor (EGF) epidermal growth factor receptor (EGFR...
Articles
Biochem Soc Trans (2012) 40 (1): 195–199.
Published: 19 January 2012
.... cancer epidermal growth factor receptor (EGFR) ErbB juxtamembrane domain receptor tyrosine kinase EGF (epidermal growth factor) and its corresponding receptor, EGFR (EGF receptor) (or ErbB1), were initially discovered by Stanley Cohen's group over 30 years ago (reviewed in [ 1 ]). The ErbB...
Articles
Biochem Soc Trans (2011) 39 (2): 568–573.
Published: 22 March 2011
... a critical role in this phenomenon. 1 To whom correspondence should be addressed (email e.odintsova@bham.ac.uk ). 28 10 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 actin adhesion dimerization epidermal growth factor receptor (EGFR) integrin...
Articles
Biochem Soc Trans (2009) 37 (1): 173–177.
Published: 20 January 2009
... ]. Thus at least a proportion of EGFRs may remain on the perimeter membrane for some time, during which they are potentially subject to dephosphorylation by cytoplasmically exposed phosphatases. epidermal growth factor receptor (EGFR) endosomal sorting complex required for transport (ESCRT...
Articles
Biochem Soc Trans (2009) 37 (1): 146–150.
Published: 20 January 2009
...) endosome epidermal growth factor receptor (EGFR) His domain phosphotyrosine phosphatase (HD-PTP) multivesicular body (MVB) Down-regulation of mitogenic tyrosine kinase receptors is a process of fundamental importance, since defective receptor down-regulation results in a failure to turn off...
Articles
Biochem Soc Trans (2007) 35 (5): 1049–1051.
Published: 25 October 2007
... 2007 Biochemical Society 2007 aldosterone epidermal growth factor receptor (EGFR) epithelial sodium channel (ENaC) hypertension protein kinase C (PKC) protein kinase D (PKD) The phosphorylation of EGFR (epidermal growth factor receptor) in response to aldosterone has been observed...
Articles
Biochem Soc Trans (2007) 35 (4): 665–668.
Published: 20 July 2007
... to target EGFR signalling in tumours of the breast and other epithelial tissues and underline the value of three-dimensional extracellular matrix culture models for exploring cancer-relevant signalling processes ex vivo . breast cancer cell line drug response epidermal growth factor receptor (EGFR...
Articles
Biochem Soc Trans (2007) 35 (1): 1–6.
Published: 22 January 2007
... 2007 The Biochemical Society 2007 diagnostics epidermal growth factor receptor (EGFR) growth factor signalling therapeutics This short review describes the work that I have been doing for the last 45 years on growth factors, their receptors and signal transduction mechanisms. When I...
Articles
Biochem Soc Trans (2006) 34 (5): 855–857.
Published: 25 October 2006
... in response to the activation of a tyrosine kinase receptor, and suggests a previously unappreciated role for this lipid as a negative modulator of Rac signalling. β2-chimaerin C1 domain diacylglycerol epidermal growth factor receptor (EGFR) phorbol ester phospholipase Cγ (PLCγ) Rac1 CFP...
Articles
Biochem Soc Trans (2003) 31 (6): 1488–1490.
Published: 01 December 2003
... of Sheffield, 21 July 2003 epidermal growth factor receptor (EGFR) proteomics signal transduction small-molecule tyrosine kinase inhibitor surrogate marker two-dimensional electrophoresis Abbreviations used: SMTKI, small-molecule tyrosine kinase inhibitor; EGFR, epidermal growth factor...
Articles
Biochem Soc Trans (2003) 31 (6): 1203–1208.
Published: 01 December 2003
... (ADAM) cancer cross-talk epidermal growth factor receptor (EGFR) G-protein-coupled receptor (GPCR) transactivation Abbreviations used: ADAM, a d isintegrin a nd m etalloprotease; ET-1, endothelin-1; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; ERK...