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Biochem Soc Trans (2023) 51 (5): 1975–1988.
Published: 13 October 2023
...Ramzan Umarov; Chung-Chau Hon Enhancers are genomic regions that regulate gene transcription and are located far away from the transcription start sites of their target genes. Enhancers are highly enriched in disease-associated variants and thus deciphering the interactions between enhancers...
Biochem Soc Trans (2022) 50 (6): 1633–1642.
Published: 09 November 2022
...Hao Deng; Gaochen Jin; Bomyi Lim Proper enhancer–promoter interactions are essential to maintaining specific transcriptional patterns and preventing ectopic gene expression. Drosophila is an ideal model organism to study transcriptional regulation due to extensively characterized regulatory regions...
Biochem Soc Trans (2022) 50 (3): 1167–1177.
Published: 23 May 2022
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . ATAC-seq chromatin accessibility cis -regulatory elements enhancer vertebrate development Genomic DNA is packaged into chromatin composed of repeating structural units called nucleosomes, where...
Biochem Soc Trans (2021) 49 (3): 1041–1054.
Published: 22 June 2021
...Lan-Hsin Wang; Marvin Angelo E. Aberin; Sean Wu; Shu-Ping Wang Enhancers are cis -regulatory elements that play essential roles in tissue-specific gene expression during development. Enhancer function in the expression of developmental genes requires precise regulation, while deregulation...
In CollectionEmbryonic development
Biochem Soc Trans (2019) 47 (2): 713–724.
Published: 05 April 2019
... the importance of zebrafish chromatin research towards the understanding of human disease and transgenerational inheritance. chromatin developmental biology enhancer epigenetics methylation zebrafish The spatial organisation of the nucleus changes as cells commit to developmental fates (reviewed...
Gabriela Ridner, Reut Bartoov-Shifman, Tatyana Zalogin, Tali Avnit-Sagi, Keren Bahar, Revital Sharivkin, Lia Kantorovich, Sara Weiss, Michael D. Walker
Biochem Soc Trans (2008) 36 (3): 360–362.
Published: 21 May 2008
... between CD22 and GPR40 contains several evolutionarily conserved sequence blocks, among them HR2 and HR3 . β-Cell-specific expression of GPR40 is controlled at the transcriptional level through HR2, a potent β-cell-specific enhancer. The mechanisms controlling cell-specific expression of the remaining...