... be addressed (email federico.turkheimer@kcl.ac.uk ). 25 2 2015 © 2015 Authors; published by Portland Press Limited 2015 endothelium genetics heterogeneity kinetic modelling methodology microglia neuroinflammation peripheral benzodiazepine receptor (PBR) PK11195 peripheral...

.... 1 To whom correspondence should be addressed (email brant@virginia.edu ) . 10 2 2015 © The Authors Journal compilation © 2015 Biochemical Society 2015 endothelium pannexin pharmacology smooth muscle vasculature A key role for purinergic signalling in vascular...

... 2014 Biochemical Society 2014 anti-angiogenic therapy endothelium gene expression glioblastoma tumour vascular abnormalization Gliomas are common malignant brain tumours in adults that occur in various grades and histopathological subclasses. Molecularly, gliomas can be divided...

... protein directly activated by cAMP). The present review outlines the role of Epac1 signalling within the endothelium and, in particular, the role of Epac1 in cytoskeletal dynamics and the control of cell morphology. The actin/cytoskeleton linker ezrin will be described in terms of the growing body...

... mauriced@queensu.ca ). 2 Present address: Pfizer Neuroscience, 610 Main Street, Cambridge, MA 02139, U.S.A. 5 12 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 cAMP cGMP cyclic nucleotide phosphodiesterase (PDE) endothelium platelet...

..., with a particular emphasis on the role of the seed coat in modulating endosperm proliferation and cellularization. The innermost layer of the seed coat, the endothelium, synthesizes flavonoids which are held to provide a defensive function against microbes, act as feeding deterrents, provide UV protection...

... 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis Delta-like ligand 4 (Dll4) endothelium Notch therapy tumour Notch signalling is an evolutionarily conserved pathway, which is mediated by cell–cell contact ( Figure 1 ). It is involved...

... cytokines in the endothelium, and the class 3 semaphorins in neurons. A widely accepted mechanism for the role of NRP1 in the endothelium is VEGF binding to NRP1 and VEGFR2 (VEGF receptor 2) and VEGF-dependent formation of complexes or NRP1–VEGFR2 holoreceptors with enhanced signalling activity...

.... The responsiveness of endothelium to Ang1 is determined by the relative levels of Tie2 and the inhibitory co-receptor Tie1 in the cells. Tie1 undergoes regulated ectodomain cleavage which is stimulated by a range of factors including VEGF (vascular endothelial growth factor), inflammatory cytokines and changes...

... to sites of infection involves a complex series of events including leucocyte tethering to the inflamed endothelium, rolling, firm adhesion, crawling and transendothelial migration [ 3 ]. These events are dependent on multiple interactions between the leucocyte and the apical membrane of the endothelial...

... reports of its role in endothelial cells and angiogenesis. 10 8 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 actomyosin contractility angiogenesis endothelium focal adhesion Rho GTPase RhoJ/TCL Endothelial cells line blood and lymphatic vessels...

...Srabasti J. Chakravorty; Katie R. Hughes; Alister G. Craig Cytoadherence of PRBCs ( Plasmodium falciparum -infected red blood cells) to host endothelium has been associated with pathology in severe malaria, but, despite extensive information on the primary processes involved in the adhesive...

... is working on the hypotheses that differences exist in how tissues of the cardiovascular system, including vessels, endothelium, heart and blood, sense pathogens compared with immune cells (principally macrophages) and that identifying such differences will reveal new therapeutic targets for the treatment...

... that vascular endothelial and smooth muscle cells of vein grafts die due to suddenly elevated blood pressure. This cell death is followed by endothelial regeneration. Central to this theme is the essential role played by EPCs (endothelial progenitor cells) in regenerating the lost endothelium. The mechanisms...

... are an increasing cause of heart disease in developed countries. 1 To whom correspondence should be addressed (email kbotham@rvc.ac.uk ). 28 2 2007 © 2007 Biochemical Society 2007 atherosclerosis chylomicron remnant dietary lipid endothelium macrophage vascular dysfunction Diet...

... Biochemical Society 2003 ATP calcium carboxy-2′,7′-dichlorofluorescein endothelium mitochondria oxidative stress Abbreviations used: BSS, balanced salt solution; [Ca 2+ ] i , cytosolic [Ca 2+ ]; [Ca 2+ ] o , extracellular [Ca 2+ ]; C-H 2 DCF, carboxy-2´,7´-dichlorodihydrofluorescein...

... Oestrogen elicits endothelium-dependent vasodilation through the release of endothelium-derived NO. This is, in part, due to the activation of endothelial NO synthase (eNOS) by the oestrogen receptor (ER) via the mitogen- activated protein kinase (MAPK) pathway [1]. However, the cross-coupling of the ER...