... be addressed (email federico.turkheimer@kcl.ac.uk ). 25 2 2015 © 2015 Authors; published by Portland Press Limited 2015 endothelium genetics heterogeneity kinetic modelling methodology microglia neuroinflammation peripheral benzodiazepine receptor (PBR) PK11195 peripheral...

...-based channels, and its effect can be replicated by other peptides of equivalent size, or by 1.5 kDa polyethylene glycol [ 11 ]. endothelium pannexin pharmacology smooth muscle vasculature A key role for purinergic signalling in vascular function has been understood for well-over half...

... important roles in this process [ 13 ]. 1 email anna.dimberg@igp.uu.se 13 10 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 anti-angiogenic therapy endothelium gene expression glioblastoma tumour vascular abnormalization Gliomas...

... Palmer (University of Glasgow, U.K.) and Stephen Yarwood (University of Glasgow, U.K.) cAMP cGMP cyclic nucleotide phosphodiesterase (PDE) endothelium platelet Cellular homoeostasis requires efficient integration of signals encoded by myriad primary messengers, including numerous...

..., with a particular emphasis on the role of the seed coat in modulating endosperm proliferation and cellularization. The innermost layer of the seed coat, the endothelium, synthesizes flavonoids which are held to provide a defensive function against microbes, act as feeding deterrents, provide UV protection...

... protein directly activated by cAMP). The present review outlines the role of Epac1 signalling within the endothelium and, in particular, the role of Epac1 in cytoskeletal dynamics and the control of cell morphology. The actin/cytoskeleton linker ezrin will be described in terms of the growing body...

... reports of its role in endothelial cells and angiogenesis. 1 To whom correspondence should be addressed (email v.heath@bham.ac.uk ). 10 8 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 actomyosin contractility angiogenesis endothelium focal adhesion...

... aharris.lab@imm.ox.ac.uk ). 6 9 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis Delta-like ligand 4 (Dll4) endothelium Notch therapy tumour Notch signalling is an evolutionarily conserved pathway, which is mediated by cell–cell contact...

... rlb682@bham.ac.uk ). 21 9 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 CD9 CD63 CD151 endothelium tetraspanin Tspan12 Endothelial cells line all blood and lymphatic vessels and are central to the regulation of vascular development and function...

... cytokines in the endothelium, and the class 3 semaphorins in neurons. A widely accepted mechanism for the role of NRP1 in the endothelium is VEGF binding to NRP1 and VEGFR2 (VEGF receptor 2) and VEGF-dependent formation of complexes or NRP1–VEGFR2 holoreceptors with enhanced signalling activity...

.... The responsiveness of endothelium to Ang1 is determined by the relative levels of Tie2 and the inhibitory co-receptor Tie1 in the cells. Tie1 undergoes regulated ectodomain cleavage which is stimulated by a range of factors including VEGF (vascular endothelial growth factor), inflammatory cytokines and changes...

...Srabasti J. Chakravorty; Katie R. Hughes; Alister G. Craig Cytoadherence of PRBCs ( Plasmodium falciparum -infected red blood cells) to host endothelium has been associated with pathology in severe malaria, but, despite extensive information on the primary processes involved in the adhesive...

... is working on the hypotheses that differences exist in how tissues of the cardiovascular system, including vessels, endothelium, heart and blood, sense pathogens compared with immune cells (principally macrophages) and that identifying such differences will reveal new therapeutic targets for the treatment...

... that vascular endothelial and smooth muscle cells of vein grafts die due to suddenly elevated blood pressure. This cell death is followed by endothelial regeneration. Central to this theme is the essential role played by EPCs (endothelial progenitor cells) in regenerating the lost endothelium. The mechanisms...

... are an increasing cause of heart disease in developed countries. 1 To whom correspondence should be addressed (email kbotham@rvc.ac.uk ). 28 2 2007 © 2007 Biochemical Society 2007 atherosclerosis chylomicron remnant dietary lipid endothelium macrophage vascular dysfunction Diet...

... Biochemical Society 2003 ATP calcium carboxy-2′,7′-dichlorofluorescein endothelium mitochondria oxidative stress Abbreviations used: BSS, balanced salt solution; [Ca 2+ ] i , cytosolic [Ca 2+ ]; [Ca 2+ ] o , extracellular [Ca 2+ ]; C-H 2 DCF, carboxy-2´,7´-dichlorodihydrofluorescein...

... meeting held at University of Liverpool, Liverpool, 4–6 September 2002 9 August 2002 Copyright 2003 Biochemical Society 2003 endothelium nitric oxide protein kinase Akt steroid hormone Abbreviations used: AF-1, ligand-independent transactivation function domain...