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Keywords: endothelial cell
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Articles
Biochem Soc Trans (2016) 44 (4): 1135–1141.
Published: 15 August 2016
...Wei Li; Richard M. Salmon; He Jiang; Nicholas W. Morrell Bone morphogenetic protein (BMP)9 and BMP10 are high affinity ligands for activin receptor-like kinase 1 (ALK1), a type I BMP receptor mainly expressed on vascular endothelial cells (ECs). ALK1-mediated BMP9/BMP10 signalling pathways have...
Articles
Biochem Soc Trans (2014) 42 (6): 1643–1646.
Published: 17 November 2014
... above and more. The basic steps of angiogenesis include enzymatic degradation of capillary basement membrane, endothelial cell proliferation and migration, tubulogenesis, vessel fusion and stabilization [ 8 – 10 ]. A large number of factors and cell types participate in the regulation of this important...
Articles
Biochem Soc Trans (2014) 42 (6): 1584–1589.
Published: 17 November 2014
... cells, ERK5 is required for preventing apoptosis, mediating shear-stress signalling and regulating tumour angiogenesis. The present review focuses on our current understanding of the role of ERK5 in regulating endothelial cell function. 1 To whom correspondence should be addressed (email...
Articles
Biochem Soc Trans (2014) 42 (6): 1590–1595.
Published: 17 November 2014
... it. angiogenesis antagonist cancer endothelial cell β3-integrin tumour In 1994, Brooks et al. [ 1 , 2 ] published two studies which reported αvβ3-integrin as a marker of angiogenic vasculature and, importantly, that it could be targeted to induce apoptosis of proliferative angiogenic vascular cells...
Articles
Biochem Soc Trans (2014) 42 (6): 1623–1628.
Published: 17 November 2014
... ). 15 9 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 angiogenesis endothelial cell integrin neuropilin semaphorin vascular endothelial growth factor vascular permeability Even though SEMA3A can bind NRP1 on embryonic blood vessels, mice lacking...
Articles
Biochem Soc Trans (2014) 42 (5): 1378–1382.
Published: 18 September 2014
... and to possibly exploit them for therapeutic strategies. 1 To whom correspondence should be addressed (email t.maffucci@qmul.ac.uk ) . 14 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 angiogenesis cilium endothelial cell phosphatidylinositol 3...
Articles
Biochem Soc Trans (2014) 42 (4): 928–933.
Published: 11 August 2014
... with cardiovascular disease, the specific effect of hyper- (or hypo-) glycaemia is less well understood. The present review focuses on the impact that glycaemic dysregulation has on respiratory function and ROS (reactive oxygen species) generation in the endothelial cells that are critical in preventing several key...
Articles
Biochem Soc Trans (2011) 39 (6): 1597–1600.
Published: 21 November 2011
...Clare Hetheridge; Georgia Mavria; Harry Mellor Angiogenesis is a complex process that involves multiple cellular events. In addition to receiving inputs from a range of stimulatory and inhibitory factors, endothelial cells undergoing angiogenesis make multiple interactions with the extracellular...
Articles
Biochem Soc Trans (2011) 39 (6): 1639–1643.
Published: 21 November 2011
...Lindsay S. Cooley; Dylan R. Edwards The mammalian vascular system consists of two distinct, but closely related, networks: the blood vasculature (itself divided into arterial and venous networks) and the lymphatic vasculature. EC (endothelial cell) lineage specification has been proposed...
Articles
Biochem Soc Trans (2011) 39 (6): 1649–1653.
Published: 21 November 2011
... for artery obstruction and affects the heart by causing myocardial infarction. The vascular wall is composed of three cell types and includes a monolayer of endothelial cells and is irrigated by a vasa vasorum. The formation of the vascular network from the vasa vasorum is a process involved...
Articles
Biochem Soc Trans (2009) 37 (6): 1189–1192.
Published: 19 November 2009
...Nader Rahimi Regulation of angiogenesis is often viewed as a balance between pro-angiogenic and anti-angiogenic factors, and when the balance shifts in favour of angiogenesis stimulators, an angiogenic switch turns on the normally inactive endothelial cells to grow new blood vessels. Recent studies...
Articles
Biochem Soc Trans (2009) 37 (6): 1248–1253.
Published: 19 November 2009
... ). 29 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis endothelial cell endothelial homoeostasis ETS transcription factor gene expression Angiogenesis, namely the formation of new blood vessels in the adult, is a tightly regulated process...
Articles
Biochem Soc Trans (2009) 37 (6): 1254–1259.
Published: 19 November 2009
... of tissues and is activated by a range of growth factors, cytokines and cellular stresses. Targeted deletion of Erk5 in mice has revealed that the ERK5 signalling cascade is critical for normal cardiovascular development and vascular integrity. In vitro studies have revealed that in endothelial cells, ERK5...
Articles
Biochem Soc Trans (2009) 37 (6): 1179–1183.
Published: 19 November 2009
... of the potential role(s) of PARs and COX enzymes in physiological angiogenesis is, however, currently lacking. Exposure of human endothelial cells to serine proteases (e.g. thrombin) or to PAR-selective agonist peptides leads to a wide range of cellular responses, including enhanced expression of COX-2, and we...
Articles
Biochem Soc Trans (2007) 35 (6): 1453–1455.
Published: 23 November 2007
... endemic exogenous agonists are mediated by non-BMDC (bone-marrow-derived cells), which can include endothelial cells. In contrast, the proatherogenic TLR2 responses to the defined synthetic exogenous agonist Pam3 CSK4 are mediated at least in part by BMDC, which can include lymphocytes, monocytes...
Articles
Biochem Soc Trans (2007) 35 (5): 1161–1162.
Published: 25 October 2007
...H.M. McGettrick; A. Filer; G.E. Rainger; C.D. Buckley; G.B. Nash Vascular endothelial cells play a pivotal role in regulating leucocyte recruitment during inflammation, and their responses can be modulated by their local environment, including cells of the tissue stroma. We have developed a model...
Articles
Biochem Soc Trans (2007) 35 (3): 442–445.
Published: 22 May 2007
...C.P.D. Wheeler-Jones Vascular disease is initiated by activation of the endothelium characterized by the predominance of pro-inflammatory and pro-coagulant changes in endothelial cells (ECs) referred to collectively as ‘endothelial dysfunction’. There is increasing evidence that lipoproteins...
Articles
Biochem Soc Trans (2007) 35 (2): 172–176.
Published: 20 March 2007
... (phosphoinositide 3-kinases). Hereditary mutation of PTEN causes tumour-susceptibility diseases such as Cowden disease. We used the Cre - loxP system to generate an endothelial cell-specific mutation of PTEN in mice. Heterozygous mutation of PTEN in endothelial cells enhances postnatal neovascularization, including...
Articles
Biochem Soc Trans (2006) 34 (6): 1005–1008.
Published: 25 October 2006
... and time. Both processes are influenced by silent chemokine receptors (interceptors), including DARC (Duffy antigen receptor for chemokines). Increasing experimental evidence suggests that DARC is involved in accumulation of extravascular chemokines in endothelial cells, chemokine transcytosis...
Articles
Biochem Soc Trans (2006) 34 (6): 1366–1369.
Published: 25 October 2006
... are particularly devastating and are associated with extremely high rates of morbidity and mortality. In addition to damaging the ischaemic arterial wall and microvasculature, reperfusion can also injure neurons and glial cells [ 1 – 3 ]. blood–brain barrier brain injury cerebral ischaemia endothelial cell...
Articles
Biochem Soc Trans (2006) 34 (6): 1370–1375.
Published: 25 October 2006
... fatty acids capable of activating PP2Cα and PP2Cβ in vitro induce apoptosis in various cell types as shown here for neurons and endothelial cells. Using RNA interference to reduce the amount of PP2Cα and PP2Cβ results in cells significantly less susceptible to the apoptotic effect of oleic acid...
Articles
Biochem Soc Trans (2006) 34 (4): 492–494.
Published: 21 July 2006
...S. Sayner; T. Stevens Within pulmonary microvascular endothelial cells, activation of endogenous adenylate cyclase generates tightly regulated cAMP transitions in the subplasma membrane space. These cAMP fluxes strengthen contacts between adjacent cells to tighten their barrier function. However...
Articles
Biochem Soc Trans (2005) 33 (2): 406–408.
Published: 01 April 2005
... dynamically to various stimuli, and controls a complex series of cellular reactions and interactions. The current presentation describes the use of computer enhanced video recording to study interactions between endothelial cells and circulating blood cells, especially leucocytes. Subsequently, modern assays...
Articles
Biochem Soc Trans (2004) 32 (6): 994–998.
Published: 26 October 2004
...C.M. Williams; V. Maitin; K.G. Jackson Lipoproteins such as LDL (low-density lipoprotein) and oxidized LDL have potentially adverse effects on endothelial cells due to their ability to activate pro-inflammatory pathways regulated via the transcription factor NF-κB (nuclear factor κB...
Articles
Biochem Soc Trans (2004) 32 (3): 397–402.
Published: 01 June 2004
... specialization and provide potentially useful guidance devices for targeted therapies. © 2004 Biochemical Society 2004 endothelial cell homing peptide integrin phage display Jubilee Lecture Vascular zip codes in angiogenesis and metastasis E. Ruoslahti1 The Burnham Institute, Cancer Research Center...
Articles
Biochem Soc Trans (2003) 31 (6): 1400–1402.
Published: 01 December 2003
... endothelial cell hyperglycaemia methylglyoxal Abbreviations used: AGE, advanced glycation end product; CEL, N ∊ -(1-carboxyethyl)lysine; CML, N ∊ -(carboxymethyl)lysine; ERK, extracellular-signal-regulated kinase; Hsp, heat-shock protein; MAPK, mitogen-activated protein kinase; MGO...