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Keywords: endoplasmic reticulum
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Biochem Soc Trans (2023) 51 (2): 571–577.
Published: 09 March 2023
...Margret Helene Bülow; Julia Sellin The study of endoplasmic reticulum (ER)-mitochondria communication is a vast and expanding field with many novel developments in the past few years. In this mini-review, we focus on several recent publications that identify novel functions of tether complexes...
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Biochem Soc Trans (2022) 50 (5): 1389–1402.
Published: 28 October 2022
... overexpression enhances autophagy and extends lifespan in yeast and Drosophila [ 68 ]. aging endoplasmic reticulum inter-organelle longevity mitochondria Over the course of evolution, cellular pathways and processes have become highly compartmentalized. Cell biologists have spent years mapping...
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Biochem Soc Trans (2021) 49 (5): 2199–2210.
Published: 19 October 2021
... the pathways of selective autophagy, two aspects of mitophagy will be covered: (i) How does a machinery normally working in association with the endoplasmic reticulum (ER) to make an autophagosome can also do so at a site distinct from the ER such as on the surface of the targeted cargo? and (ii) how does...
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Biochem Soc Trans (2020) 48 (5): 2173–2184.
Published: 29 October 2020
...Yu-Jie Chen; Parikshit Bagchi; Billy Tsai The endoplasmic reticulum (ER), with its expansive membranous system and a vast network of chaperones, enzymes, sensors, and ion channels, orchestrates diverse cellular functions, ranging from protein synthesis, folding, secretion, and degradation to lipid...
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Biochem Soc Trans (2020) 48 (1): 199–205.
Published: 17 February 2020
... little attention has been dedicated to signaling at endomembranes. In this review, I will discuss recent evidence that we obtained on signaling of tyrosine kinases at the surface of the endoplasmic reticulum (ER), as well as in the lumen of this organelle. I will discuss how tyrosine kinase signaling...
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Biochem Soc Trans (2020) 48 (1): 187–197.
Published: 17 February 2020
... ( dematteis@tigem.it ) 6 11 2019 20 1 2020 24 1 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 endoplasmic reticulum golgi apparatus membrane contact sites phosphatidylinositol Membrane contact sites (MCSs...
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Biochem Soc Trans (2018) 46 (3): 699–706.
Published: 25 May 2018
...Marisa Loi; Ilaria Fregno; Concetta Guerra; Maurizio Molinari The endoplasmic reticulum (ER) is the site of protein, lipid, phospholipid, steroid and oligosaccharide synthesis and modification, calcium ion storage, and detoxification of endogenous and exogenous products. Its volume (and activity...
Articles
Biochem Soc Trans (2018) 46 (2): 437–452.
Published: 27 March 2018
... to maintain a defined protein and lipid composition in both their membranes. The maintenance of mitochondrial membrane identity requires a selective and regulated transport of specific lipids from/to the endoplasmic reticulum (ER) and across the mitochondria outer and inner membranes. Since...
Articles
Biochem Soc Trans (2017) 45 (6): 1323–1331.
Published: 17 November 2017
... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . autophagy endoplasmic reticulum trafficking The discovery of the omegasome was a major breakthrough in autophagy research with respect...
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Articles
Biochem Soc Trans (2016) 44 (2): 499–504.
Published: 11 April 2016
...Alexander R. van Vliet; Patrizia Agostinis The endoplasmic reticulum (ER) is the main hub of cellular Ca 2+ signalling and protein synthesis and folding. The ER moreover is the central player in the formation of contact sites with other organelles and structures, including mitochondria, plasma...
Articles
Biochem Soc Trans (2016) 44 (2): 546–553.
Published: 11 April 2016
... ) and IP 3 receptor (IP 3 R) on the endoplasmic reticulum (ER). A less understood, parallel Ca 2+ signalling cascade is that involving the messenger nicotinic acid adenine dinucleotide phosphate (NAADP) that couples to Ca 2+ release from acidic Ca 2+ stores [e.g. endo-lysosomes, secretory vesicles...
Articles
Biochem Soc Trans (2016) 44 (2): 493–498.
Published: 11 April 2016
... complexes. STARD3 [StAR (steroidogenic acute regulatory protein)-related lipid transfer domain-3] and its close paralogue STARD3NL (STARD3 N-terminal like) are involved in the formation of contacts between late-endosomes and the endoplasmic reticulum (ER). The lipid transfer protein (LTP) STARD3...
Articles
Biochem Soc Trans (2016) 44 (2): 425–430.
Published: 11 April 2016
... organellar architecture during the transfer process. Even though the molecular compositions of membrane contact sites are diverse, it is striking that several of these sites, including contact sites between the endoplasmic reticulum (ER) and endosomes, Golgi and the plasma membrane (PM), and contact sites...
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Articles
Biochem Soc Trans (2014) 42 (5): 1335–1342.
Published: 18 September 2014
... banafshe.larijani@ikerbasque.org or dlpoccia@amherst.edu ) . 14 8 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 diacylglycerol endoplasmic reticulum membrane fusion nuclear envelope phosphoinositide In recent years, cell and developmental biologists have...
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Biochem Soc Trans (2014) 42 (4): 905–908.
Published: 11 August 2014
... the endoplasmic reticulum: too reducing and disulfides will not form, too oxidizing and non-native disulfides will not be resolved. How the endoplasmic reticulum maintains the correct redox balance is unknown. Although we have a good appreciation of the processes leading to a more oxidizing environment, our...
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Biochem Soc Trans (2014) 42 (1): 63–70.
Published: 23 January 2014
... groups of IP 3 , but synthetic ligands can use other interactions to make these essential contacts ( Figure 1 D). © The Authors Journal compilation © 2014 Biochemical Society 2014 calcium signalling cAMP endoplasmic reticulum inositol 1 4 5-trisphosphate receptor (IP 3 receptor) lysosome...
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Biochem Soc Trans (2012) 40 (6): 1348–1352.
Published: 21 November 2012
... the ER (endoplasmic reticulum) to create a replicating niche called the BCV ( Brucella -containing vacuole). The ER is a suitable strategic place for pathogenic Brucella . Indeed, bacteria can be hidden from host cell defences to persist within the host, and they can take advantage of the membrane...
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Biochem Soc Trans (2012) 40 (1): 112–118.
Published: 19 January 2012
...Wei-Wei Shen; Nicolas Demaurex The SOCE (store-operated Ca 2+ entry) pathway is a central component of cell signalling that links the Ca 2+ -filling state of the ER (endoplasmic reticulum) to the activation of Ca 2+ -permeable channels at the PM (plasma membrane). SOCE channels maintain a high free...
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Biochem Soc Trans (2011) 39 (5): 1544–1548.
Published: 21 September 2011
... endoplasmic reticulum farnesol reactive oxygen species (ROS) FOH (farnesol), a non-sterol isoprenoid produced by dephosphorylation of farnesyl pyrophosphate, has been shown to inhibit proliferation and induce apoptosis in neoplastic cell lines and also to be effective in chemoprevention...
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Biochem Soc Trans (2010) 38 (6): 1537–1542.
Published: 24 November 2010
... at the endoplasmic reticulum, follow the same pattern. By using a series of chimaeric transcripts, we have demonstrated that transcript localization at the endoplasmic reticulum bypasses the signals dictating stress granule sequestration. Polysome profile analyses and protein synthesis experiments indicate...
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Biochem Soc Trans (2010) 38 (3): 747–753.
Published: 24 May 2010
...Lawrence R. Griffing The network of the ER (endoplasmic reticulum) is set up by cytoskeletal control of the movement and remodelling of polygonal rings of tubules, bundles of tubules and cisternal regions. We have developed a new image analysis tool, persistency mapping, to understand the framework...
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Biochem Soc Trans (2010) 38 (3): 755–760.
Published: 24 May 2010
... endoplasmic reticulum Golgi body microtubule plant The woody secondary walls of plants provide the mechanical stability for upward growth while permitting the plant to withstand considerable external forces that would otherwise lead to lodging and breakage. In mature xylem vessels, the secondary...
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Biochem Soc Trans (2009) 37 (6): 1399–1403.
Published: 19 November 2009
... The Authors Journal compilation © 2009 Biochemical Society 2009 adenosine deaminase that acts on RNA (ADAR) central nervous system (CNS) endoplasmic reticulum γ-aminobutyric acid type A receptor (GABA A receptor) RNA editing transmembrane region 1 To whom correspondence should...
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Biochem Soc Trans (2009) 37 (5): 961–965.
Published: 21 September 2009
...Becky Bola; Viki Allan The ER (endoplasmic reticulum) is a fascinating organelle that is highly dynamic, undergoing constant movement and reorganization. It has many key roles, including protein synthesis, folding and trafficking, calcium homoeostasis and lipid synthesis. It can expand in size when...
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Biochem Soc Trans (2007) 35 (5): 970–973.
Published: 25 October 2007
...B. Nyfeler; H.-P. Hauri The ER (endoplasmic reticulum) is a major protein folding and modification organelle. In its lumen, the ER processes a third of all newly synthesized proteins. To accomplish this task, numerous resident proteins capture the nascent and newly synthesized proteins...
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Biochem Soc Trans (2007) 35 (1): 96–100.
Published: 22 January 2007
... refill of internal Ca 2+ stores is accomplished with minimal increase in [Ca 2+ ] i unless the SERCA (sarcoplasmic/endoplasmic-reticulum Ca 2+ -ATPase) pump activity is blocked. This suggested that ER is closely apposed to the PM, enabling Ca 2+ that is entering the cell to be rapidly taken up...
Articles
Biochem Soc Trans (2006) 34 (5): 910–912.
Published: 25 October 2006
... be addressed (email cwt1000@cam.ac.uk ). 19 6 2006 © 2006 The Biochemical Society 2006 endoplasmic reticulum inositol 1,4,5-trisphosphate receptor (IP 3 receptor) patch–clamp recording plasma membrane protein targeting store-operated Ca 2+ entry The most unexpected feature...
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Biochem Soc Trans (2006) 34 (5): 922–926.
Published: 25 October 2006
... the relatively well-characterized IP 3 and ryanodine receptors. Furthermore, in the sea urchin egg, the NAADP-sensitive store appears to be separate from the endoplasmic reticulum and is most likely an acidic store. These findings have also been reinforced by similar findings in mammalian cells, and a unified...
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Biochem Soc Trans (2006) 34 (3): 404–408.
Published: 22 May 2006
...J.-Y. Choi; W.R. Riekhof; W.-I. Wu; D.R. Voelker PtdSer (phosphatidylserine) is synthesized in the endoplasmic reticulum and the related MAM (mitochondria-associated membrane), and transported to the PtdSer decarboxylases, Pds1p in the mitochondria, and Psd2p in the Golgi. Genetic and biochemical...
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Biochem Soc Trans (2006) 34 (3): 395–398.
Published: 22 May 2006
... by photosynthesis. Lipid biosynthetic enzymes of different subcellular compartments participate in the biogenesis of the thylakoid membrane system. This process requires the extensive exchange of lipid precursors between the chloroplast and the ER (endoplasmic reticulum). The underlying lipid trafficking phenomena...
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Biochem Soc Trans (2006) 34 (3): 351–355.
Published: 22 May 2006
...G.A. Rutter A number of studies in recent years have demonstrated that the ER (endoplasmic reticulum) makes intimate contacts with mitochondria, the latter organelles existing both as individual organelles and occasionally as a more extensive interconnected network. Demonstrations that mitochondria...
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Articles
Biochem Soc Trans (2006) 34 (3): 367–369.
Published: 22 May 2006
...H. Riezman Sphingolipids are important signalling molecules and thus it is very important to understand how they are generated. Sphingolipid biosynthesis shows a conserved compartmentalization in eukaryotic cells. Their synthesis begins in the endoplasmic reticulum and is completed in the Golgi...
Articles
Biochem Soc Trans (2006) 34 (3): 359–362.
Published: 22 May 2006
... of these pathways moves exogenous sterols from the plasma membrane to the endoplasmic reticulum in the yeast Saccharomyces cerevisiae . We have found that two classes of proteins play critical roles in this transport, ABC transporters (ATP-binding-cassette transporters) and oxysterol-binding protein-related...
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Biochem Soc Trans (2005) 33 (5): 1016–1018.
Published: 26 October 2005
... ( Figure 1 ), proteins are initially translocated into the ER (endoplasmic reticulum). They then travel through the Golgi complex, where they can enter two possible pathways: (i) a route to LV via a PVC/MVB (prevacuolar compartment/multivesicular body) [ 7 , 8 ]. This is mediated by a sorting receptor...
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Biochem Soc Trans (2004) 32 (5): 655–658.
Published: 26 October 2004
...C.E. Jessop; S. Chakravarthi; R.H. Watkins; N.J. Bulleid Native disulphide bonds are essential for the structure and function of many membrane and secretory proteins. Disulphide bonds are formed, reduced and isomerized in the endoplasmic reticulum of mammalian cells by a family of oxidoreductases...
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Biochem Soc Trans (2004) 32 (5): 663–667.
Published: 26 October 2004
...L. Ellgaard Disulphide bonds are critical for the maturation and stability of secretory and cell-surface proteins. In eukaryotic cells, disulphide bonds are introduced in the ER (endoplasmic reticulum), where the redox conditions are optimal to support their formation. Yet, the correct pairing...
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Biochem Soc Trans (2004) 32 (3): 524–528.
Published: 01 June 2004
.... These included citrate synthase, which is known to be targeted to mitochondria, peroxisomes and glyoxysomes, and luminal binding protein, which is an ER (endoplasmic reticulum)-resident protein. Searches of the Arabidopsis database revealed that there are several genes encoding putative citrate synthase...
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Biochem Soc Trans (2003) 31 (6): 1238–1242.
Published: 01 December 2003
... that tail-anchored proteins translocate their C-termini across the endoplasmic reticulum membrane by a mechanism different from that used for Sec61-dependent post-translational signal-peptide-driven translocation. Here we summarize recent results on the insertion of tail-anchored proteins and discuss...
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Biochem Soc Trans (2003) 31 (6): 1243–1247.
Published: 01 December 2003
...B. Martoglio Signal sequences are the addresses of proteins destined for secretion. In eukaryotic cells, they mediate targeting to the endoplasmic reticulum membrane and insertion into the translocon. Thereafter, signal sequences are cleaved from the pre-protein and liberated into the endoplasmic...
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Biochem Soc Trans (2003) 31 (6): 1253–1256.
Published: 01 December 2003
...A.V. Nikonov; G. Kreibich Protein translocation in the ER (endoplasmic reticulum) and N-glycosylation are fundamental processes essential for the normal functioning of eukaryotic cells. They are the initial steps in the intracellular pathway that are followed by secretory proteins and membrane...
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Biochem Soc Trans (2003) 31 (6): 1260–1262.
Published: 01 December 2003
... processes. In the case of ricin, the process inhibited is protein synthesis. In order to reach their cytosolic substrates, several toxins undergo retrograde transport to the ER (endoplasmic reticulum) before translocating across the ER membrane. To achieve this export, these toxins exploit the ERAD (ER...
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Biochem Soc Trans (2003) 31 (4): 885–888.
Published: 01 August 2003
.... While these interactions have been most thoroughly studied with respect to the receptor at the synapse, the same proteins may also interact with the receptor much earlier in its biosynthetic pathway and play important roles in receptor trafficking from the endoplasmic reticulum to the synapse. 1...
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Biochem Soc Trans (2003) 31 (4): 875–879.
Published: 01 August 2003
...K. Bollan; L.A. Robertson; H. Tang; C.N. Connolly Mammalian γ-aminobutyric acid type A (GABA A ) receptors are constructed from a large repertoire of subunits (α1–α6, β1–β3, γ1–γ3, δ, ∊, θ and π) into a pentameric ion channel. GABA A receptor assembly occurs within the endoplasmic reticulum (ER...