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Keywords: embryonic stem cell
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Biochem Soc Trans (2013) 41 (3): 711–719.
Published: 23 May 2013
... of pluripotent cells in vitro . Recent studies have, however, found that the choice of culture condition has a significant impact on epigenetic profiles of cultured pluripotent cells. Mouse and human ESCs (embryonic stem cells) show substantial epigenetic differences that are dependent on the culture condition...
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Biochem Soc Trans (2011) 39 (1): 383–387.
Published: 19 January 2011
...Raymond A.A. Smith; Kate Meade; Claire E. Pickford; Rebecca J. Holley; Catherine L.R. Merry ES (embryonic stem) cell differentiation is dependent on the presence of HS (heparan sulfate). We have demonstrated that, during differentiation, the evolution of specific cell lineages is associated...
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Biochem Soc Trans (2010) 38 (4): 1033–1036.
Published: 26 July 2010
... alternative sources of human hepatocytes which circumvent these issues. The research in our group has focused on generating human hepatic endoderm from the scalable pluripotent stem cell populations, human embryonic stem cells and induced pluripotent stem cells. We have developed efficient and scalable models...
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Biochem Soc Trans (2010) 38 (4): 1027–1032.
Published: 26 July 2010
.... This is the foundation of mammalian development and of ES (embryonic stem) cell biology. What are the design principles of this naïve cell state? How is pluripotency acquired and maintained? Suppressing activation of ERKs (extracellular-signal-regulated kinases) is critical to establishing and sustaining ES cells...
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Biochem Soc Trans (2005) 33 (6): 1526–1530.
Published: 26 October 2005
... embryonic stem cell germ cell tumour pluripotentcy teratocarcinoma Despite their similarities, teratocarcinoma-derived EC cells present only a caricature of ES cells. In contrast with ES cells, EC cells often only have a limited capacity for differentiation, and many EC cell lines have completely...
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