... to structural biology as the cryo-electron microscopy revolution has brought us new insights into the structure and mechanism of ABCG2. In this update, we evaluate the degree to which new data have enhanced our understanding of the structure and mechanism of ABCG2 and whether we are now in a position...

... 2010 docking electron microscopy exocytosis filamentous actin (F-actin) Munc18-1 syntaxin-1 In electron micrographs of synapses and chromaffin cells, many synaptic and secretory vesicles are found morphologically docked at the target membrane. Morphologically docked vesicles...

... hydrophobic region of α-synuclein comprising residues 71–82 is required for aggregation of the protein into the fibrillar form found in pathogenic aggregates [Giasson, Murray, Trojanowski and Lee (2001) J. Biol. Chem. 276 , 2380–2386]. In the present study, we used 2 H NMR and electron microscopy...

... interface comprises a relatively large, or even scattered, area. Molecular electron microscopy and single-particle analysis were performed on a headpiece fragment of integrin α5β1 in the presence and absence of bound ligand (Fn fragment), and revealed a marked shape change of the β subunit hybrid and I-like...

... on the structural information about the final, mature fibril and in particular the complementary techniques of cryo-electron microscopy, solid-state NMR and X-ray fibre diffraction. 1 To whom correspondence should be addressed (e-mail Is279@cam.ac.uk ) 6 3 2002 © 2002 Biochemical Society 2002...