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Keywords: elastase
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Biochem Soc Trans (2011) 39 (5): 1450–1454.
Published: 21 September 2011
...-derived serine proteases elastase and proteinase-3 by a competitive tight-binding mechanism. Furthermore, it inhibits EVE (endogenous vascular elastase). Studies on several animal models show that antiprotease augmentation with human elafin is an effective strategy in the treatment of inflammatory...
Biochem Soc Trans (2006) 34 (2): 279–282.
Published: 20 March 2006
...P.M. Fitch; A. Roghanian; S.E.M. Howie; J.-M. Sallenave Recent evidence shows that human neutrophil elastase inhibitors can be synthesized locally at mucosal sites. In addition to efficiently targeting bacterial and host enzymes, they can be released in the interstitium and in the lumen of mucosa...
Biochem Soc Trans (2002) 30 (2): 111–115.
Published: 01 April 2002
...J.-M. Sallenave Low-molecular-mass neutrophil elastase inhibitors have been shown to be important in the control of lung inflammation. In addition to inhibiting the enzyme neutrophil elastase, these low-molecular-mass compounds (10 kDa) have been shown to have other activities. For example...