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Keywords: dyskinesia
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Biochem Soc Trans (2014) 42 (2): 600–604.
Published: 20 March 2014
... movements (dyskinesias) within a few years. The mechanisms underlying the development of LIDs ( L -dopa-induced dyskinesias) involve, on one hand, a presynaptic dysregulation of dopamine release and clearance and, on the other hand, an abnormal postsynaptic response to dopamine in the brain...
Biochem Soc Trans (2010) 38 (2): 493–497.
Published: 22 March 2010
... of them, similarly to patients, exhibit a reduction in the efficacy of the drug and disabling AIMs (abnormal involuntary movements) defined, as a whole, as L -dopa-induced dyskinesia. In those animals experiencing AIMs, synaptic plasticity is altered and is paralleled by modifications in the postsynaptic...