...Zhilin Yang; Ryan L. Hanson; Eric Batchelor The dynamics of p53 expression provide a mechanism to increase differentiation between cellular stresses and specificity in appropriate responses. Here, we review recent advances in our understanding of the molecular mechanisms regulating p53 dynamics...

.... Membrane funnels (commonly known as necks and pores) are frequently observed as transient states during fusion and fission of membrane vesicles in cells. However, caveolae display atypical dynamics where the membrane funnel can be stabilized over an extended period of time, resulting in cell surface...

... transport of ions. Tight coordination of the motions of the pump is required to couple the two spatially distant processes of ion binding and ATP hydrolysis. Here, we review our current understanding of the structural dynamics of P-type ATPases, focusing primarily on Ca 2+ pumps. We integrate different...

... regions of the protein, which change conformation depending on the nucleotide present, mediate this switch. A large number of X-ray, NMR and simulation studies have shown that this is an over-simplification. The switch regions themselves are highly dynamic and can exist in distinct sub-states in the GTP...

... Markus.Zweckstetter@dzne.de ) . 27 1 2015 © 2015 Authors; published by Portland Press Limited 2015 dynamics nuclear magnetic resonance (NMR) peripheral benzodiazepine receptor 1-(2-chlorophenyl)- N -methyl- N -(1-methylpropyl)-3-isoquinolinecarboxamide (PK11195) structure TSPO...

... ribonucleoprotein particles) and numerous protein factors. Assembly of these snRNPs and associated proteins is a highly dynamic process, making it challenging to study the conformational rearrangements and spliceosome assembly kinetics in bulk studies. In the present review, we discuss recent studies utilizing...

...Eve M. Simcox; Amy Reeve; Doug Turnbull Mitochondrial dynamics are essential for maintaining organelle stability and function. Through fission, fusion and mitophagic events, optimal populations of mitochondria are retained. Subsequently, alterations in such processes can have profound effects...

.... allostery dynamics oligomerization p53 protein complex quaternary structure The modularity of biological systems facilitates their representation as networks, enabling the use of graph theory to systematically and quantitatively analyse these highly complex systems. Protein systems networks can...

... and ATP production. Consequently, turnover of the electron transfer protein complexes must be fast, so k on and k off are as high as possible. cytochrome c dynamics myoglobin redox protein References 1 Schreiber G. Haran G. Zhou H.X. Fundamental aspects of protein...

...Mikael Akke Protein conformational dynamics can be critical for ligand binding in two ways that relate to kinetics and thermodynamics respectively. First, conformational transitions between different substates can control access to the binding site (kinetics). Secondly, differences between free...

... that the same can be true for molecular biology. In particular, and using basic modular methods of mathematical modelling which are standard in control theory, a set of dynamic models is developed for some illustrative cell signalling processes. These models, supported by recent experimental evidence, are used...

... frameworks that can be used to model such networks, and the types of algorithms available for their reconstruction. We then focus on dynamic models, typically described using differential equations, and explain the two main reconstruction approaches in current use. We discuss the data requirements...

... averaging constraints and spontaneous emission selection rules inherent in all conventional techniques. Applications of STED to the study of molecular probe dynamics are presented, together with studies of STED dynamics in a new push–push two-photon chromophore. 1 To whom correspondence should...