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Keywords: drug target
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Biochem Soc Trans (2010) 38 (2): 466–470.
Published: 22 March 2010
... disease amyloidosis C-reactive protein (CRP) drug target transthyretin (TTR) The ideal drug development project involves the elucidation of pathological biochemical or cellular processes in order to identify and target influential molecules; although this ideal can rarely be followed. Rather...
Biochem Soc Trans (2008) 36 (4): 555–565.
Published: 22 July 2008
... million people worldwide each year. Thus an understanding of drug-resistance mechanisms, the immunobiology of cell wall components to elucidate host–pathogen interactions and the discovery of new drug targets are now required for the treatment of TB. Above the plasma membrane is a classical chemotype IV...
Biochem Soc Trans (2007) 35 (2): 314–317.
Published: 20 March 2007
... Lo.Persson@med.lu.se 18 10 2006 © 2007 The Biochemical Society 2007 decarboxylase drug target ornithine decarboxylase (ODC) polyamine protozoan parasite S-adenosylmethionine Infectious diseases caused by protozoan parasites represent a major public health problem around...
Biochem Soc Trans (2005) 33 (4): 802–805.
Published: 01 August 2005
... and MS. Because Mycobacterium tuberculosis DAPA AT is a potential drug target, this enzyme was cloned, overexpressed and purified to homogeneity for biochemical characterization. Inactivation of Escherichia coli DAPA AT by amiclenomycin and analogues was carefully studied using different approaches...