... insights into tumor heterogeneity, cancer genome remodeling, and drug resistance. Correspondence: Paul Mischel ( pmischel@stanford.edu ) 12 7 2022 17 10 2022 17 10 2022 © 2022 The Author(s) 2022 This is an open access article published by Portland Press Limited on behalf...

... of virulence and drug resistance traits. We focus on the contribution of comparative genomics, population genomics and directed evolution studies. In addition, we discuss how different types of genomic mutations (small or structural variants) contribute to intraspecific differences in virulence or drug...

... as genomic junk. LncRNAs are involved in various physiological as well as pathological conditions, and play a key role in drug resistance, gene expression, and epigenetic regulation. This review mainly focuses on exploring the multifunctional roles of candidate lncRNAs, and their strong association with TNBC...

... resistance mechanisms. Correspondence: Sima Lev ( sima.lev@weizmann.ac.il ) 4 2 2020 26 3 2020 30 3 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 drug resistance EGFR target therapy Triple-negative breast...

... given in combination to circumvent chemoresistance, but several studies have demonstrated it to be ineffective in the absence of radiotherapy. The identification of children with drug-resistant disease at the outset could allow stratification of those that are potentially curable by chemotherapy alone...

... prompted investigation into the cellular mechanisms that underpin drug resistance and the evaluation of a number of novel therapies and drug combinations [ 5 – 7 ]. Despite these efforts, relapse following initial bortezomib-driven remission remains an enduring clinical issue 10 years after bortezomib...

..., NRG treatment rescued viability in eight out of nine lines [ 35 ]. Taken together, these reports strongly suggest a role for HER3 ligand up-regulation in a large subset of HER2-amplified cells with acquired resistance. cancer drug resistance epidermal growth factor receptor (EGFR) human...

... Journal compilation © 2014 Biochemical Society 2014 BRAF drug resistance melanoma microphthalmia-associated transcription factor (MITF) mitogen-activated protein kinase pathway (MAPK pathway) mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase (MEK) Melanoma...

... efficacy. 1 These authors contributed equally to this work. 2 To whom correspondence should be addressed (email bentires@fmi.ch ). 23 1 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 breast cancer drug resistance phosphoinositide 3...

... Biochemical Society 2014 cancer cross-talk drug resistance Hippo/mammalian sterile 20 (MST) pathway phosphoinositide 3-kinase (PI3K)/Akt pathway phosphorylation protein–protein interaction RAS-association domain family 1 isoform A (RASSF1A) RAS/mitogen-activated protein kinase (MAPK) pathway...

...Rupak Doshi; Daniel A.P. Gutmann; Yvonne S.K. Khoo; Lisa A. Fagg; Hendrik W. van Veen Multidrug transporters have a crucial role in causing the drug resistance that can arise in infectious micro-organisms and tumours. These integral membrane proteins mediate the export of a broad range of unrelated...

... that, upon stress withdrawal, endoplasmic-reticulum-bound transcripts resume translation faster than those at the cytosol, which have been sequestered into stress granules. This may represent a novel mechanism by which drug-resistant cells respond quickly to stress, helping them to survive the cytotoxic...

... or rp47@hotmail.com ). 31 5 2005 © 2005 The Biochemical Society 2005 Candida albicans drug resistance ergosterol lipid raft morphogenesis sphingolipid The existence of discrete membrane microdomains, known as lipid rafts within a lipid bilayer, predominantly composed...