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Keywords: drug resistance
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Biochem Soc Trans (2020) 48 (6): 2791–2810.
Published: 01 December 2020
... as genomic junk. LncRNAs are involved in various physiological as well as pathological conditions, and play a key role in drug resistance, gene expression, and epigenetic regulation. This review mainly focuses on exploring the multifunctional roles of candidate lncRNAs, and their strong association with TNBC...
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Biochem Soc Trans (2015) 43 (5): 1018–1022.
Published: 09 October 2015
... given in combination to circumvent chemoresistance, but several studies have demonstrated it to be ineffective in the absence of radiotherapy. The identification of children with drug-resistant disease at the outset could allow stratification of those that are potentially curable by chemotherapy alone...
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Biochem Soc Trans (2014) 42 (4): 804–808.
Published: 11 August 2014
... ]. The inevitability of MM relapse following bortezomib treatment has prompted investigation into the cellular mechanisms that underpin drug resistance and the evaluation of a number of novel therapies and drug combinations [ 5 – 7 ]. Despite these efforts, relapse following initial bortezomib-driven remission remains...
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Biochem Soc Trans (2014) 42 (4): 816–821.
Published: 11 August 2014
... Correspondence may be addressed to either of these authors (email david.romano@ucd.ie or walter.kolch@ucd.ie ). 21 1 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 cancer cross-talk drug resistance Hippo/mammalian sterile 20 (MST) pathway phosphoinositide 3...
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Biochem Soc Trans (2014) 42 (4): 831–836.
Published: 11 August 2014
...@cancer.org.uk ). 14 2 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 cancer drug resistance epidermal growth factor receptor (EGFR) human epidermal growth factor receptor 2 (HER2) human epidermal growth factor receptor 3 (HER3) kinase inhibition...
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Biochem Soc Trans (2014) 42 (4): 727–732.
Published: 11 August 2014
... responses. 1 email Claudia.Wellbrock@manchester.ac.uk 14 1 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 BRAF drug resistance melanoma microphthalmia-associated transcription factor (MITF) mitogen-activated protein kinase pathway (MAPK pathway...
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Biochem Soc Trans (2011) 39 (3): 807–811.
Published: 20 May 2011
...Rupak Doshi; Daniel A.P. Gutmann; Yvonne S.K. Khoo; Lisa A. Fagg; Hendrik W. van Veen Multidrug transporters have a crucial role in causing the drug resistance that can arise in infectious micro-organisms and tumours. These integral membrane proteins mediate the export of a broad range of unrelated...
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Biochem Soc Trans (2010) 38 (6): 1537–1542.
Published: 24 November 2010
... that, upon stress withdrawal, endoplasmic-reticulum-bound transcripts resume translation faster than those at the cytosol, which have been sequestered into stress granules. This may represent a novel mechanism by which drug-resistant cells respond quickly to stress, helping them to survive the cytotoxic...
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Biochem Soc Trans (2005) 33 (5): 1219–1223.
Published: 26 October 2005
... albicans drug resistance ergosterol lipid raft morphogenesis sphingolipid The existence of discrete membrane microdomains, known as lipid rafts within a lipid bilayer, predominantly composed of sphingolipid and sterol, are well documented in several systems [ 1 – 5 ]. Interestingly...