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Keywords: drug resistance
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Biochem Soc Trans (2020) 48 (6): 2791–2810.
Published: 01 December 2020
... as genomic junk. LncRNAs are involved in various physiological as well as pathological conditions, and play a key role in drug resistance, gene expression, and epigenetic regulation. This review mainly focuses on exploring the multifunctional roles of candidate lncRNAs, and their strong association with TNBC...
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Biochem Soc Trans (2015) 43 (5): 1018–1022.
Published: 09 October 2015
... given in combination to circumvent chemoresistance, but several studies have demonstrated it to be ineffective in the absence of radiotherapy. The identification of children with drug-resistant disease at the outset could allow stratification of those that are potentially curable by chemotherapy alone...
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Biochem Soc Trans (2014) 42 (4): 804–808.
Published: 11 August 2014
... prompted investigation into the cellular mechanisms that underpin drug resistance and the evaluation of a number of novel therapies and drug combinations [ 5 – 7 ]. Despite these efforts, relapse following initial bortezomib-driven remission remains an enduring clinical issue 10 years after bortezomib...
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Biochem Soc Trans (2014) 42 (4): 831–836.
Published: 11 August 2014
..., NRG treatment rescued viability in eight out of nine lines [ 35 ]. Taken together, these reports strongly suggest a role for HER3 ligand up-regulation in a large subset of HER2-amplified cells with acquired resistance. cancer drug resistance epidermal growth factor receptor (EGFR) human...
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Biochem Soc Trans (2014) 42 (4): 727–732.
Published: 11 August 2014
... Journal compilation © 2014 Biochemical Society 2014 BRAF drug resistance melanoma microphthalmia-associated transcription factor (MITF) mitogen-activated protein kinase pathway (MAPK pathway) mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase (MEK) Melanoma...
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Biochem Soc Trans (2014) 42 (4): 816–821.
Published: 11 August 2014
... Biochemical Society 2014 cancer cross-talk drug resistance Hippo/mammalian sterile 20 (MST) pathway phosphoinositide 3-kinase (PI3K)/Akt pathway phosphorylation protein–protein interaction RAS-association domain family 1 isoform A (RASSF1A) RAS/mitogen-activated protein kinase (MAPK) pathway...
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Biochem Soc Trans (2011) 39 (3): 807–811.
Published: 20 May 2011
...Rupak Doshi; Daniel A.P. Gutmann; Yvonne S.K. Khoo; Lisa A. Fagg; Hendrik W. van Veen Multidrug transporters have a crucial role in causing the drug resistance that can arise in infectious micro-organisms and tumours. These integral membrane proteins mediate the export of a broad range of unrelated...
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Biochem Soc Trans (2010) 38 (6): 1537–1542.
Published: 24 November 2010
... that, upon stress withdrawal, endoplasmic-reticulum-bound transcripts resume translation faster than those at the cytosol, which have been sequestered into stress granules. This may represent a novel mechanism by which drug-resistant cells respond quickly to stress, helping them to survive the cytotoxic...
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Biochem Soc Trans (2005) 33 (5): 1219–1223.
Published: 26 October 2005
... or rp47@hotmail.com ). 31 5 2005 © 2005 The Biochemical Society 2005 Candida albicans drug resistance ergosterol lipid raft morphogenesis sphingolipid The existence of discrete membrane microdomains, known as lipid rafts within a lipid bilayer, predominantly composed...