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Keywords: drug discovery and design
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Biochem Soc Trans (2023) 51 (3): 925–936.
Published: 09 June 2023
... with residue boundaries for Neh1-7. The Neh2 domain contains the Keap1 DLG and ETGE degron sequences and the Neh6 domain contains the DSGIS and DSAPGS phosphodegrons. βTrCP cancer drug discovery and design NRF2 Table 1. Previously reported bTrCP substrates Gene code Gene...
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Biochem Soc Trans (2023) 51 (1): 373–385.
Published: 16 February 2023
...). Published by Portland Press Limited on behalf of the Biochemical Society 2023 allosteric regulation drug discovery and design kinases Eukaryotic protein kinases regulate a wide array of cellular processes through the catalytic transfer of a phosphate group from adenosine triphosphate (ATP...
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Biochem Soc Trans (2023) 51 (1): 13–20.
Published: 23 January 2023
... by the participation of University of Cambridge in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. biological networks cellular localization drug discovery and design G-protein-coupled receptors signalling systems...
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Biochem Soc Trans (2023) 51 (1): 195–206.
Published: 06 January 2023
... into the era of artificial intelligence. Correspondence: Fernán Agüero ( fernan@iib.unsam.edu.ar ) 20 10 2022 1 12 2022 5 12 2022 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 chemogenomics drug discovery and design...
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Biochem Soc Trans (2022) 50 (5): 1315–1328.
Published: 05 October 2022
... discovery and design metabolic engineering In the context of NP biosynthesis in E. coli , metabolic engineering has been used to build chassis strains such as HM0079 and BAP1, that are optimized to support the synthesis of complex NPs by expressing phosphopantetheine transferase, an enzyme crucial...
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Biochem Soc Trans (2022) 50 (2): 665–673.
Published: 19 April 2022
... © 2022 The Author(s) 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . drug discovery and design organ on chip translational science The high...
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Biochem Soc Trans (2022) 50 (2): 747–758.
Published: 14 March 2022
..., and scientific publications [ 15 ]. 9 12 2021 8 2 2022 21 2 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 computational biochemistry computational biology drug discovery and design molecular docking platforms protein...
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Biochem Soc Trans (2021) 49 (6): 2627–2638.
Published: 23 November 2021
... development of the technique. biologics cryo-EM drug discovery and design small molecule vaccines Structure-based drug design (SBDD) has been an essential tool in pharmaceutical development for decades. Structures of macromolecular drug targets, especially when bound to modulators, can reveal...
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Biochem Soc Trans (2020) 48 (2): 693–707.
Published: 20 April 2020
... ) or Davide M. Ferraris ( davide.ferraris@uniupo.it ) 16 12 2019 10 3 2020 16 3 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cancer drug discovery and design malaria NAD biology NAD dehydrogenases tuberculosis...
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Biochem Soc Trans (2020) 48 (1): 281–290.
Published: 24 December 2019
...@glasgow.ac.uk ) 30 10 2019 4 12 2019 9 12 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 drug discovery and design palmitoylation protein S-acylation thioesterase zDHHC protein acyltransferase Protein S-acylation...
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Biochem Soc Trans (2019) 47 (3): 909–918.
Published: 13 May 2019
... Carloni ( p.carloni@fz-juelich.de ) drug discovery and design molecular dynamics neuropathology Counteracting the derangement associated with neurodegenerative diseases, such as Alzheimer's and Parkinson's, [ 1 , 2 ] is an increasingly critical issue in our aging society [ 3 ]. The slow...
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Biochem Soc Trans (2018) 46 (6): 1753–1770.
Published: 13 December 2018
... analyses suggest that autoinhibition is mediated by competition between ‘acid box’ and heparan sulfate binding, and through back-binding of D1 to the FGF binding-site on domains D2 and D3 [ 28 – 31 ]. drug discovery and design fibroblast growth factor receptors receptor tyrosine kinases...
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Biochem Soc Trans (2018) 46 (5): 1367–1379.
Published: 21 September 2018
... be found in the reviews cited above. computational biochemistry drug discovery and design structural biology Computational methods of drug discovery have a basis in the very earliest structural studies of protein molecules. The first structure of a protein, that of sperm whale myoglobin...
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Biochem Soc Trans (2018) 46 (4): 789–796.
Published: 22 June 2018
.... ( 2007 ) Leishmania amazonensis: multiple receptor-ligand interactions are involved in amastigote infection of human dendritic cells . Exp. Parasitol. 116 , 306 – 310 . drug discovery and design heparan sulfate host–pathogen interactions Leishmania parasitology proteoglycan...
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Biochem Soc Trans (2017) 45 (2): 571–582.
Published: 13 April 2017
... BY) . calnexin drug discovery and design glucosidase glycobiology iminosugar Enveloped viruses have a membrane surrounding their capsid, which is composed of lipids derived from host membranes and viral glycoproteins. These viral glycoproteins are typically dependent upon the host endoplasmic...