... to this work. 1 11 2022 31 1 2023 1 2 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 allosteric regulation drug discovery and design kinases Eukaryotic protein kinases regulate a wide array of cellular processes...

... of Cambridge in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. biological networks cellular localization drug discovery and design G-protein-coupled receptors signalling systems biology GPCR...

... into the era of artificial intelligence. Correspondence: Fernán Agüero ( fernan@iib.unsam.edu.ar ) 20 10 2022 1 12 2022 5 12 2022 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 chemogenomics drug discovery and design...

... 2022 The Author(s) 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . breast cancers cancer drug discovery and design JNK molecular scaffolds...

...-ND) . antibiotics biosynthesis drug discovery and design metabolic engineering Antimicrobial-resistant (AMR) infections pose a serious threat to society [ 1 ], driving the need to discover and develop new antimicrobial molecules. Promising sources of such antimicrobials are naturally...

... © 2022 The Author(s) 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . drug discovery and design organ on chip translational science The high...

... Society 2022 computational biochemistry computational biology drug discovery and design molecular docking platforms protein structure Drug repurposing possesses great advantages in terms of establishing new therapeutic options for specific disorders by exploiting drugs used for other...

... the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . biologics cryo-EM drug discovery and design small molecule vaccines Structure-based drug design (SBDD) has been an essential tool in pharmaceutical development for decades. Structures of macromolecular drug targets, especially when...

... ) or Davide M. Ferraris ( davide.ferraris@uniupo.it ) 16 12 2019 10 3 2020 16 3 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cancer drug discovery and design malaria NAD biology NAD dehydrogenases tuberculosis...

...@glasgow.ac.uk ) 30 10 2019 4 12 2019 9 12 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 drug discovery and design palmitoylation protein S-acylation thioesterase zDHHC protein acyltransferase Protein S-acylation...

... which pose different challenges for MD simulations from our own research. While by no means this article intends to be exhaustive, it will illustrate some of the current challenges and advantages of MD in investigating highly diverse targets for pharmaceutical intervention. drug discovery...

...) 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . drug discovery and design fibroblast growth factor receptors receptor tyrosine kinases structural biology...

...: Michael W. Parker ( mwp@unimelb.edu.au ) 27 6 2018 8 8 2018 13 8 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 computational biochemistry drug discovery and design structural biology Computational methods...

... ( marissa.maciej-hulme@radboudumc.nl ) 21 2 2018 25 4 2018 26 4 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 drug discovery and design heparan sulfate host–pathogen interactions Leishmania parasitology proteoglycan...

... BY) . calnexin drug discovery and design glucosidase glycobiology iminosugar Enveloped viruses have a membrane surrounding their capsid, which is composed of lipids derived from host membranes and viral glycoproteins. These viral glycoproteins are typically dependent upon the host endoplasmic...