... and the Biochemical Society under a transformative agreement with JISC. βTrCP cancer drug discovery and design NRF2 beta -Transducin repeat-containing protein (βTrCP) is one of 69 human F-box proteins [ 1–3 ] that play roles in regulating the activity of cell cycle proteins and transcription factors...

... to this work. 1 11 2022 31 1 2023 1 2 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 allosteric regulation drug discovery and design kinases Eukaryotic protein kinases regulate a wide array of cellular processes...

... with Portland Press and the Biochemical Society under a transformative agreement with JISC. biological networks cellular localization drug discovery and design G-protein-coupled receptors signalling systems biology GPCR signalling constitutes a central mechanism allowing cells to sense...

... into the era of artificial intelligence. Correspondence: Fernán Agüero ( fernan@iib.unsam.edu.ar ) 20 10 2022 1 12 2022 5 12 2022 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 chemogenomics drug discovery and design...

... Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . breast cancers cancer drug discovery and design JNK molecular scaffolds therapeutics The c-Jun N-terminal Kinases (JNKs) are members of the mitogen-activated...

...-ND) . antibiotics biosynthesis drug discovery and design metabolic engineering Antimicrobial-resistant (AMR) infections pose a serious threat to society [ 1 ], driving the need to discover and develop new antimicrobial molecules. Promising sources of such antimicrobials are naturally...

... the Creative Commons Attribution License 4.0 (CC BY) . drug discovery and design organ on chip translational science The high attrition rate the pharmaceutical industry is still facing indicates that the current tools for conducting research too often fail in predicting the outcome in patients...

... Society 2022 computational biochemistry computational biology drug discovery and design molecular docking platforms protein structure Drug repurposing possesses great advantages in terms of establishing new therapeutic options for specific disorders by exploiting drugs used for other...

... the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . biologics cryo-EM drug discovery and design small molecule vaccines Structure-based drug design (SBDD) has been an essential tool in pharmaceutical development for decades. Structures of macromolecular drug targets, especially when...

... drug discovery and design malaria NAD biology NAD dehydrogenases tuberculosis Dehydrogenases are strictly conserved enzymes in all domains of life and catalyze the oxidation of their substrate(s) through the engagement of a reducing electron acceptor, usually NAD + /NADP + , or a flavin...

...@glasgow.ac.uk ) 30 10 2019 4 12 2019 9 12 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 drug discovery and design palmitoylation protein S-acylation thioesterase zDHHC protein acyltransferase zDHHC-PATs are zinc...

... Carloni ( p.carloni@fz-juelich.de ) drug discovery and design molecular dynamics neuropathology Counteracting the derangement associated with neurodegenerative diseases, such as Alzheimer's and Parkinson's, [ 1 , 2 ] is an increasingly critical issue in our aging society [ 3 ]. The slow...

... analyses suggest that autoinhibition is mediated by competition between ‘acid box’ and heparan sulfate binding, and through back-binding of D1 to the FGF binding-site on domains D2 and D3 [ 28 – 31 ]. drug discovery and design fibroblast growth factor receptors receptor tyrosine kinases...

... be found in the reviews cited above. computational biochemistry drug discovery and design structural biology Computational methods of drug discovery have a basis in the very earliest structural studies of protein molecules. The first structure of a protein, that of sperm whale myoglobin...

.... ( 2007 ) Leishmania amazonensis: multiple receptor-ligand interactions are involved in amastigote infection of human dendritic cells . Exp. Parasitol. 116 , 306 – 310 . drug discovery and design heparan sulfate host–pathogen interactions Leishmania parasitology proteoglycan...

... BY) . calnexin drug discovery and design glucosidase glycobiology iminosugar Enveloped viruses have a membrane surrounding their capsid, which is composed of lipids derived from host membranes and viral glycoproteins. These viral glycoproteins are typically dependent upon the host endoplasmic...