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Keywords: double-strand break
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Biochem Soc Trans (2009) 37 (3): 597–604.
Published: 20 May 2009
...) DNA-damage response double-strand break Fanconi's anaemia homologous recombination ubiquitination BRCA1 is an important tumour-suppressor gene. Germline mutations in BRCA1 are present in nearly 50% of inherited breast cancer cases, and the acquisition of a single defective allele leads...
Biochem Soc Trans (2005) 33 (6): 1447–1450.
Published: 26 October 2005
...M.A. Macris; P. Sung Homologous recombination (HR) is a major pathway for the elimination of DNA DSBs (double-strand breaks) induced by high-energy radiation and chemicals, or that arise due to endogenous damage and stalled DNA replication forks. If not processed properly, DSBs can lead to cell...