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Keywords: dopamine
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Articles
Biochem Soc Trans (2012) 40 (5): 1111–1116.
Published: 19 September 2012
... of LRRK2 (leucine-rich repeat kinase 2), a protein that mutated represents the main genetic cause of familial PD described to date. Neurotransmission relies on proper presynaptic vesicle trafficking; defects in this process, variation in dopamine flow and alteration of presynaptic plasticity have been...
Articles
Biochem Soc Trans (2012) 40 (5): 1080–1085.
Published: 19 September 2012
.... In particular, LRRK2 has been suggested to play roles in cytoskeletal dynamics, synaptic machinery, dopamine homoeostasis and autophagic processes. Our understanding of how these pathways are affected, their contribution towards PD development and their interaction with one another is still incomplete, however...
Articles
Biochem Soc Trans (2010) 38 (2): 493–497.
Published: 22 March 2010
... characterized by the massive degeneration of dopaminergic neurons projecting to the striatum. In fact, a peculiar aspect of striatal plasticity is the modulation exerted by DA (dopamine) on LTP and LTD. Our understanding of these maladaptive forms of plasticity has mostly come from the electrophysiological...
Articles
Biochem Soc Trans (2009) 37 (1): 313–317.
Published: 20 January 2009
...Chantal Martin-Soelch The neural substrates of MDD (major depressive disorder) are complex and not yet fully understood. In the present review, I provide a short overview of the findings supporting the hypothesis of a dysfunctional dopamine system in the pathophysiology of depression. Because...
Articles
Articles
Biochem Soc Trans (2004) 32 (6): 1032–1036.
Published: 26 October 2004
...F.J.S. Lee; F. Liu Considerable evidence has accumulated describing a complex interaction between the dopaminergic and glutamatergic pathways. Efforts to describe the mechanisms underlying this complex interaction have implicated a functional interaction between dopamine and glutamate receptors...
Articles
Biochem Soc Trans (2004) 32 (5): 888–891.
Published: 26 October 2004
...@organon.co.uk 30 7 2004 © 2004 The Biochemical Society 2004 The D 1 dopamine receptor is expressed widely in the brain with high levels in the striatum, nucleus accumbens, olfactory tubercle and cortex. This receptor has a number of physiological functions (e.g. motor control). The D 1...