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Keywords: directed evolution
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Articles
Biochem Soc Trans (2023) 51 (5): 1957–1966.
Published: 03 October 2023
... require improvement: In catalytic properties such as substrate and product specificity, k cat , and K M ; and in general compatibility with the milieu of cells that express the enzyme. Continuous directed evolution systems can deliver both types of improvement and are so far the most broadly effective way...
Articles
Biochem Soc Trans (2019) 47 (2): 701–711.
Published: 22 March 2019
... and design. Correspondence: Matthew Wilding ( matthew.wilding@anu.edu.au ) or Colin Jackson ( colin.jackson@anu.edu.au ) 18 1 2019 18 1 2019 18 2 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 directed evolution...
Articles
Biochem Soc Trans (2016) 44 (4): 1165–1175.
Published: 15 August 2016
... complexity from simple systems made from biological molecules–gaining a deeper understanding of life in the process. Directed evolution is a powerful tool in Synthetic Biology, able to bypass gaps in knowledge and capable of engineering even the most highly conserved biological processes. It encompasses...
Articles
Biochem Soc Trans (2016) 44 (1): 129–142.
Published: 09 February 2016
... understanding of the structure–activity relationship of GTs, directed evolution continues to be a useful approach for generating additional mutants with functionality that can be screened for in a high-throughput format. Mutating the amino acid residues constituting or close to the substrate-binding sites...
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Articles
Biochem Soc Trans (2006) 34 (6): 1215–1218.
Published: 25 October 2006
... The Biochemical Society 2006 bacterial cytochrome P450 CYP106A2 directed evolution steroid whole-cell biocatalysis Cytochromes P450 comprise a superfamily of related enzymes, which are responsible for the metabolism of a wide variety of hydrophobic compounds [ 1 , 2 ]. Cytochromes P450 are found...
Articles
Biochem Soc Trans (2006) 34 (2): 328–329.
Published: 20 March 2006
... and highlight the expression of Boolean logic in gene regulation using multiple orthogonal pairs. 1 To whom correspondence should be addressed (email chin@mrc-lmb.cam.ac.uk ). 16 1 2006 © 2006 The Biochemical Society 2006 directed evolution gene regulatory circuit genetic code...