...). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cancer dimerization hippo pathway protein kinases SARAH domain signal transduction The Hippo pathway was originally discovered in Drosophila from genetic screens designed to identify pathways the regulate...

... Press and the Biochemical Society. dimerization GTPase kinase inhibitors leucine rich repeat kinase Parkinson's disease Parkinson's disease (PD) is the second most common neurodegenerative disease [ 1 ]. Despite the fact that the etiology of PD is mostly unknown, genome-wide...

... dimerization which has emerged as an important step in the allosteric regulation of RAS function. Correspondence: John P. O'Bryan ( obryanjo@musc.edu ) 6 7 2020 31 7 2020 5 8 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020...

... long time. Nevertheless, it is now recognized that alternative splicing variants of GPCRs greatly increase the total number of receptor isoforms and can regulate receptor trafficking and signalling. Furthermore, dimerization of these truncated variants with other receptors concurs to expand receptor...

... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY) . diffusion dimerization fluorescent ligand fluorescence correlation spectroscopy G protein-coupled receptor The plasma membrane of living cells has been...

...Pablo G. Jambrina; Olga Bohuszewicz; Nicolae-Viorel Buchete; Walter Kolch; Edina Rosta Protein phosphorylation is one of the most common post-translational modifications in cell regulatory mechanisms. Dimerization plays also a crucial role in the kinase activity of many kinases, including RAF, CDK2...

... complexes point to Ets domains functioning as versatile protein-interaction modules. In the present paper, we review the progress made over the last decade to elucidate the structural mechanisms involved in modulation of DNA binding and protein partner selection during dimerization. We see that Ets domains...

...Sarah R. Needham; Laura C. Zanetti-Domingues; Michael Hirsch; Daniel J. Rolfe; Christopher J. Tynan; Selene K. Roberts; Marisa L. Martin-Fernandez; David T. Clarke Dimerization and higher-order oligomerization are believed to play an important role in the activation of the EGFR (epidermal growth...

... not stimulate ligand-independent activation of ErbB receptors in epithelial cells. However, integrin-dependent adhesion potentiated ligand-induced activation of EGFR (epidermal growth factor receptor) and ErbB2 and facilitated receptor homo- and hetero-dimerization. The actin cytoskeleton appeared to play...

... and in coupling to G-proteins, signalling pathways activated in response to VIP, agonist-dependent receptor down-regulation, phosphorylation and internalization as well as pharmacological consequences of receptor hetero-dimerization. © The Authors Journal compilation © 2007 Biochemical Society 2007...

... crystal structure dimerization DNA binding nuclear receptor transcription The AR (androgen receptor) is a member of the steroid hormone receptor subfamily of the nuclear receptors and therefore shares with its co-members a conserved three-domain structure consisting of an NTD (N-terminal...

... and the approaches that have been applied to monitoring the selectivity and the basis of α 1 -adrenoceptor dimerization are discussed. Signalling Outwards and Inwards: A Focus Topic at BioScience2004, held at SECC Glasgow, U.K., 18–22 July 2004. Edited by J. Challiss (Leicester, U.K.), A. Harwood (University...

... the mechanism of activation of GABA B receptor and examine any possible role of GABA B2 . 1 To whom correspondence should be addressed (email Laurent.Prezeau@ccipe.cnrs.fr ). 6 7 2004 © 2004 The Biochemical Society 2004 activation mechanism allostery dimerization γ-aminobutyric acid-B...