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Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 952–956.
Published: 25 October 2007
... (sarcoplasmic reticulum) calcium release channel in triggering arrhythmias. Mutant RyR2 channels give rise to spontaneous release of calcium (Ca 2+ ) from the SR during diastole, which enhances the probability of ventricular arrhythmias. Several molecular mechanisms have been proposed to explain the gain...