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Keywords: development
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Articles
Biochem Soc Trans (2022) 50 (6): 1693–1702.
Published: 16 November 2022
..., has been associated with many pre- or post-natal brain developmental delays [ 32 , 33 ]. Because it is highly nutrient responsive as well as involved in major cell signaling, O- GlcNAcylation emerges as a target of choice to explain how nutrition can impact early brain development. This is partly...
Articles
Biochem Soc Trans (2020) 48 (2): 463–478.
Published: 20 April 2020
... development. PIAS4 effect is partially caused by the SUMOylation of Developmental Pluripotency Associated 2 (DPPA2), which converts this transcriptional activator to a potent inhibitor of zygotic transcriptional program [ 51 ]. In agreement, another study shows that overexpression of PIAS4 after fertilization...
Articles
Biochem Soc Trans (2020) 48 (1): 301–315.
Published: 03 February 2020
... signalling reviews, the reader is referred to Ref. [ 1 , 2 , 4 , 113 ]. Given the emerging link between cancer stemness and disease progression, a better mechanistic understanding of how the PI3K pathway impinges on critical developmental processes — either in forward (normal development) or reverse...
Articles
Biochem Soc Trans (2016) 44 (3): 696–701.
Published: 09 June 2016
... under the Creative Commons Attribution Licence 4.0 (CC BY) . Normal embryonic development consists, in the main, of three processes that operate cyclically ( Figure 1 ). One is patterning, which can create differences between cells that were identical, either de novo , as in the pattern...
Articles
Biochem Soc Trans (2014) 42 (5): 1263–1269.
Published: 18 September 2014
..., a developmentally regulated cell-surface heparan sulfate proteoglycan, is expressed on developing axons and growth cones Dev. Biol. 1997 184 320 332 10.1006/dbio.1997.8532 9133438 19 de Wit J. O’Sullivan M.L. Savas J.N. Condomitti G. Caccese M.C. Vennekens K.M. Yates J.R...
Articles
Biochem Soc Trans (2014) 42 (4): 1229–1237.
Published: 11 August 2014
... . Epab −/− females, but not males, are sterile [ 64 , 65 ]. In mammals, hormonal signals trigger the development and maturation of oocytes within follicles that progress through a series of developmental stages and contain somatic cells that respond to and support the growing oocyte. Epab −/− mice...
Articles
Biochem Soc Trans (2014) 42 (4): 1168–1173.
Published: 11 August 2014
... and possibly the presence of upstream ORFs in the 5′UTR [ 25 ]. The importance of NMD for normal development has been established in earlier genetic studies that uncovered major defects in embryos lacking key NMD factors [ 26 ]. Further underscoring its developmental significance, NMD is known to co...
Articles
Biochem Soc Trans (2014) 42 (3): 689–695.
Published: 22 May 2014
... to drive differentiation towards a particular therapeutically relevant cell type. 1 To whom correspondence should be addressed (email catherine.merry@manchester.ac.uk ). 21 3 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 development differentiation...
Articles
Biochem Soc Trans (2013) 41 (6): 1720–1725.
Published: 20 November 2013
... of the sites of replication initiation, or origins, across the genome. Interestingly, origin usage changes during development and in different pathologies, suggesting an integral interplay between the establishment of replication initiation along the chromosomes and cellular function. The present review...
Articles
Biochem Soc Trans (2013) 41 (6): 1489–1494.
Published: 20 November 2013
... in embryogenesis and development. Many autophagy gene-knockout mice have embryonic lethality at different stages of development. Furthermore, interactions of autophagy with crucial developmental pathways such as Wnt, Shh (Sonic Hedgehog), TGFβ (transforming growth factor β) and FGF (fibroblast growth factor) have...
Articles
Biochem Soc Trans (2012) 40 (4): 784–788.
Published: 20 July 2012
... to increased inclusion of CD44 alternative exons associated with metastasis. Recent research has identified new physiological target RNAs for Tra2β in development, and revealed it as an important developmental splicing regulator. Gradients in Tra2β protein concentrations may drive exon inclusion...
Articles
Biochem Soc Trans (2010) 38 (4): 1137–1143.
Published: 26 July 2010
... Drosophila developmental processes via their post-transcriptional effects on mRNA degradation and translation. The importance of mRNA degradation in development is illustrated by the phenotypes of animals where mRNA turnover pathways have been disrupted. For example, recent work in Drosophila has...
Articles
Biochem Soc Trans (2010) 38 (2): 507–510.
Published: 22 March 2010
..., loss of FMRP results in increased synaptic number and morphological differences during early postnatal development [ 13 , 28 , 32 – 35 ]. The early increase in dendritic spine length and density in pyramidal cells of S1 of Fmr1 -knockout mice appears to be developmentally regulated and is not detected...
Articles
Biochem Soc Trans (2008) 36 (6): 1267–1271.
Published: 19 November 2008
... the developmental trajectories of brain regions and processes are not uniform with respect to onset, peak activity and quiescence [ 5 ]. Thus the effect of any nutrient deficiency on the developing brain will be a function of the timing of the deficiency relative to any given brain region's need for that nutrient...
Articles
Biochem Soc Trans (2008) 36 (5): 868–873.
Published: 19 September 2008
..., as divergent results have been obtained related to the Lwr-mediated nuclear localization of Dl and Dorsal-related immunity factor [ 33 , 55 ]. A growing body of evidence relates SUMOylation to crucial cellular and developmental processes. In development, where transcription, translation and cellular...
Articles
Biochem Soc Trans (2008) 36 (4): 629–631.
Published: 22 July 2008
...Jörg Hartkamp; Stefan G.E. Roberts The Wilms' tumour-suppressor gene ( WT1 ), encodes a zinc-finger transcription factor that is critical for the development of several organs, including the kidneys, gonads and spleen. Despite its identification as a tumour suppressor that plays a crucial role...
Articles
Biochem Soc Trans (2004) 32 (5): 792–796.
Published: 26 October 2004
...H. Wang; Y. Lee; C.C. Malbon Wnt signalling in development operates via members of the Frizzleds, G-protein-coupled receptors that bind specific Wnt ligands and mediate signalling via distinct pathways. The Wnt/Ca 2+ /cGMP pathway mediated by Frizzled-2 was discovered recently. Activation...
Articles
Biochem Soc Trans (2001) 29 (2): 76–80.
Published: 01 May 2001
...F. Villarroya; S. Brun; M. Giralt; Y. Cámara; G. Solanes; R. Iglesias Uncoupling proteins (UCPs) are considered to be major determinants of energy expenditure in mammals. During development in rodents, the expression of the UCP genes occurs sequentially. UCP2 mRNA is expressed long before birth...