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Keywords: development
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Biochem Soc Trans (2020) 48 (2): 463–478.
Published: 20 April 2020
... the expression and/or roles of SUMOs, E1, E2, ligases or proteases and then, we provide examples of SUMO target proteins and the effect of SUMOylation in their function during development. Table 2 SUMOylation components in developmental processes Organ/Process SUMO/Ubc9 E3 Ligase De...
Biochem Soc Trans (2020) 48 (1): 301–315.
Published: 03 February 2020
... signalling reviews, the reader is referred to Ref. [ 1 , 2 , 4 , 113 ]. Given the emerging link between cancer stemness and disease progression, a better mechanistic understanding of how the PI3K pathway impinges on critical developmental processes — either in forward (normal development) or reverse...
Biochem Soc Trans (2016) 44 (3): 696–701.
Published: 09 June 2016
... to culture conditions may be very useful in growing stem cells and differentiating them towards a desired fate. None of these custom ‘tissues’ are natural outcomes of our evolved developmental mechanisms, so their production requires deliberate interference with cells, their environment or both...
Biochem Soc Trans (2014) 42 (5): 1263–1269.
Published: 18 September 2014
... development; forebrain and hypothalamus late in development [ 53 ] Unknown in brain Developmental overgrowth including brain, characteristic of Simpson–Golabi–Behmel syndrome, perinatal death (some viable) [ 57 ] Glypican 4 HS Highest in development, also in adult [ 2 ] Throughout CNS, strong...
Biochem Soc Trans (2014) 42 (4): 1229–1237.
Published: 11 August 2014
... [ 64 , 65 ]. In mammals, hormonal signals trigger the development and maturation of oocytes within follicles that progress through a series of developmental stages and contain somatic cells that respond to and support the growing oocyte. Epab −/− mice have normal oestrus and normal follicle numbers...
Biochem Soc Trans (2014) 42 (4): 1168–1173.
Published: 11 August 2014
... and possibly the presence of upstream ORFs in the 5′UTR [ 25 ]. The importance of NMD for normal development has been established in earlier genetic studies that uncovered major defects in embryos lacking key NMD factors [ 26 ]. Further underscoring its developmental significance, NMD is known to co...
Biochem Soc Trans (2014) 42 (3): 689–695.
Published: 22 May 2014
... to drive differentiation towards a particular therapeutically relevant cell type. 1 To whom correspondence should be addressed (email catherine.merry@manchester.ac.uk ). 21 3 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 development differentiation...
Biochem Soc Trans (2013) 41 (6): 1489–1494.
Published: 20 November 2013
... in embryogenesis and development. Many autophagy gene-knockout mice have embryonic lethality at different stages of development. Furthermore, interactions of autophagy with crucial developmental pathways such as Wnt, Shh (Sonic Hedgehog), TGFβ (transforming growth factor β) and FGF (fibroblast growth factor) have...
Biochem Soc Trans (2013) 41 (6): 1720–1725.
Published: 20 November 2013
... of the sites of replication initiation, or origins, across the genome. Interestingly, origin usage changes during development and in different pathologies, suggesting an integral interplay between the establishment of replication initiation along the chromosomes and cellular function. The present review...
Biochem Soc Trans (2012) 40 (4): 784–788.
Published: 20 July 2012
... for Tra2β in development, and revealed it as an important developmental splicing regulator. Gradients in Tra2β protein concentrations may drive exon inclusion patterns over development, leading to the regulated production of developmentally important protein isoforms. Alternatively, Tra2β might provide...
Biochem Soc Trans (2010) 38 (4): 1137–1143.
Published: 26 July 2010
... to development is to study a well-characterized model organism, such as Drosophila melanogaster . The present review aims to outline the mechanisms of mRNA degradation and then focus on the role of miRNAs (microRNAs) as factors affecting particular Drosophila developmental processes via their post...
Biochem Soc Trans (2010) 38 (2): 507–510.
Published: 22 March 2010
.... Furthermore, the transience of certain developmental phenotypes and the persistence of others into maturity raise the possibility that FMRP has different roles at distinct times in development. It is apparent that the loss of FMRP has widespread effects on brain development, ranging from changes...
Biochem Soc Trans (2008) 36 (6): 1267–1271.
Published: 19 November 2008
... deficiency and brain development Semin. Pediatr. Neurol. 2006 13 158 65 4 Palmer C. Roberts R.L. Bero C. Deferoxamine posttreatment reduces ischemic brain injury in neonatal rats Stroke 1994 25 1039 1045 5 Thompson R.A. Nelson C.A. Developmental science...
Biochem Soc Trans (2008) 36 (5): 868–873.
Published: 19 September 2008
.... 2006 103 10358 10363 19 Pilot F. Philippe J.M. Lemmers C. Chauvin J.P. Lecuit T. Developmental control of nuclear morphogenesis and anchoring by charleston, identified in a functional genomic screen of Drosophila cellularisation Development 2006 133 711 723...
Biochem Soc Trans (2008) 36 (4): 629–631.
Published: 22 July 2008
...Jörg Hartkamp; Stefan G.E. Roberts The Wilms' tumour-suppressor gene ( WT1 ), encodes a zinc-finger transcription factor that is critical for the development of several organs, including the kidneys, gonads and spleen. Despite its identification as a tumour suppressor that plays a crucial role...
Biochem Soc Trans (2004) 32 (5): 792–796.
Published: 26 October 2004
...H. Wang; Y. Lee; C.C. Malbon Wnt signalling in development operates via members of the Frizzleds, G-protein-coupled receptors that bind specific Wnt ligands and mediate signalling via distinct pathways. The Wnt/Ca 2+ /cGMP pathway mediated by Frizzled-2 was discovered recently. Activation...
Biochem Soc Trans (2001) 29 (2): 76–80.
Published: 01 May 2001
...F. Villarroya; S. Brun; M. Giralt; Y. Cámara; G. Solanes; R. Iglesias Uncoupling proteins (UCPs) are considered to be major determinants of energy expenditure in mammals. During development in rodents, the expression of the UCP genes occurs sequentially. UCP2 mRNA is expressed long before birth...