... pharmacological drugs. The natural sphingolipid sphingosine exhibits lysosomotropic detergent ability and is an endogenous candidate for controlling lysosomal membrane permeabilization. The lysosomotropic properties of certain detergents might be of use in lysosome-targeting anticancer drugs and drug delivery...

... structure determination [ 12 ]. 1 To whom correspondence should be addressed ( fiona.marshall@heptares.com ). 5 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 detergent G-protein-coupled receptor membrane protein thermostability The lack...

... and functional mechanisms of this focal protein. Understanding the structure and function of membrane proteins is hampered by inherent difficulties associated with their purification since the choice of the detergents play a critical role in the protein structure and stability. In the present mini-review, we...

... Society 2011 ATPase detergent drug interaction lipid–protein interaction membrane sarcoplasmic/endoplasmic reticulum Ca 2+ -ATPase (SERCA) When we began planning the Biochemical Society Annual Symposium on Recent Advances in Membrane Biochemistry back in May 2009, we had two aims. It had...

...Richard J. Cogdell; Alastair T. Gardiner; Aleksander W. Roszak; Sigitas Stončius; Pavel Kočovský; Neil W. Isaacs Electron-density maps for the crystal structures of membrane proteins often show features suggesting binding of lipids and/or detergent molecules on the hydrophobic surface, but usually...

... the binding of cofactors and the provision of structural support. The challenges of modelling surface-associated electron density features such as lipids, detergents, small amphiphiles and ions are discussed. The (bacterio)chlorophyll-containing membrane proteins that catalyse photosynthetic energy...

...P.J. Bond; J. Cuthbertson; M.S.P. Sansom Interactions between membrane proteins and detergents are important in biophysical and structural studies and are also biologically relevant in the context of folding and transport. Despite a paucity of high-resolution data on protein–detergent interactions...