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Keywords: degron
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Biochem Soc Trans (2020) 48 (4): 1557–1567.
Published: 06 July 2020
...Richard T. Timms; Itay Koren Selective protein degradation by the ubiquitin-proteasome system (UPS) is thought to be governed primarily by the recognition of specific motifs — degrons — present in substrate proteins. The ends of proteins — the N- and C-termini – have unique properties...
Biochem Soc Trans (2010) 38 (1): 78–82.
Published: 19 January 2010
... proteolysis is a highly specific endeavour. The respective ubiquitin ligase must be able to identify its victims and to differentiate them from innocent bystanders. Once the code, or ‘degron’ is deciphered, it is possible to search the entire proteome to identify the substrates of the respective ligase...