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Keywords: deadenylation
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Articles
Biochem Soc Trans (2012) 40 (4): 856–864.
Published: 20 July 2012
...Matthew Brook; Nicola K. Gray The function of cytoplasmic PABPs [poly(A)-binding proteins] in promoting mRNA translation has been intensively studied. However, PABPs also have less clearly defined functions in mRNA turnover including roles in default deadenylation, a major rate-limiting step...
Articles
Biochem Soc Trans (2012) 40 (4): 865–869.
Published: 20 July 2012
... in human mitochondria Nature 1981 290 470 474 9 Chen C.Y. Shyu A.B. Mechanisms of deadenylation-dependent decay Wiley Interdiscip. Rev.: RNA 2011 2 167 183 10 Yasukawa T. Reyes A. Cluett T.J. Yang M.Y. Bowmaker M. Jacobs H.T. Holt I.J...
Articles
Biochem Soc Trans (2010) 38 (6): 1531–1536.
Published: 24 November 2010
...(A) tail (deadenylation) slows down translation of the mRNA, or prevents it entirely, by inducing mRNA decay. Thus deadenylation plays a crucial role in the post-transcriptional regulation of gene expression, deciding the fate of individual mRNAs. It acts both in basal mRNA turnover, as well...
Articles
Biochem Soc Trans (2010) 38 (6): 1602–1607.
Published: 24 November 2010
... (email nms@mole.bio.cam.ac.uk ). 30 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 deadenylation LSm1–7 complex Pat1a Pat1b p54/DDX6/Dhh1/Me31B virus The transition between actively translating mRNAs and those targeted for degradation...
Articles
Biochem Soc Trans (2010) 38 (1): 242–251.
Published: 19 January 2010
... and proteins that serve a dual function: first, they harbour mRNAs that are translationally silenced, and such mRNA can exit again from P-bodies to re-engage in translation. Secondly, P-bodies recruit mRNAs that are targeted for deadenylation and degradation by the decapping/Xrn1 pathway. Whereas certain...
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Articles
Biochem Soc Trans (2008) 36 (4): 665–670.
Published: 22 July 2008
... regulated during meiosis. We have recently deciphered a combinatorial code that can be used to qualitatively and quantitatively predict the translational behaviour of CPE-containing mRNAs. This code defines positive and negative feedback loops that generate waves of polyadenylation and deadenylation...
Articles
Biochem Soc Trans (2005) 33 (6): 1541–1543.
Published: 26 October 2005
...H.B. Osborne; C. Gautier-Courteille; A. Graindorge; C. Barreau; Y. Audic; R. Thuret; N. Pollet; L. Paillard EDEN (embryo deadenylation element)-dependent deadenylation is a regulatory process that was initially identified in Xenopus laevis early embryos and was subsequently shown to exist...
Articles
Biochem Soc Trans (2002) 30 (6): 945–952.
Published: 01 November 2002
... of the mRNA and decreased secretion of the protein. Recent evidence suggests that TTP can accomplish this accelerated mRNA degradation by first promoting removal of the polyadenylated tail from the mRNA (deadenylation). In functional assays in cells, the other family members have similar activities...