...Matthew Brook; Nicola K. Gray The function of cytoplasmic PABPs [poly(A)-binding proteins] in promoting mRNA translation has been intensively studied. However, PABPs also have less clearly defined functions in mRNA turnover including roles in default deadenylation, a major rate-limiting step...

... in human mitochondria Nature 1981 290 470 474 9 Chen C.Y. Shyu A.B. Mechanisms of deadenylation-dependent decay Wiley Interdiscip. Rev.: RNA 2011 2 167 183 10 Yasukawa T. Reyes A. Cluett T.J. Yang M.Y. Bowmaker M. Jacobs H.T. Holt I.J...

... the Drosophila (HPat) and human Pat1b are involved in 5′→3′ mRNA decay in tissue culture cells. Indeed, HPat and hPat1b have been demonstrated to link the deadenylation and decapping steps in mRNA decay, using tethering assays alongside knockdowns of Dcp1/Edc4 or overexpression of dominant versions of Caf1...

...(A) tail (deadenylation) slows down translation of the mRNA, or prevents it entirely, by inducing mRNA decay. Thus deadenylation plays a crucial role in the post-transcriptional regulation of gene expression, deciding the fate of individual mRNAs. It acts both in basal mRNA turnover, as well...

... and proteins that serve a dual function: first, they harbour mRNAs that are translationally silenced, and such mRNA can exit again from P-bodies to re-engage in translation. Secondly, P-bodies recruit mRNAs that are targeted for deadenylation and degradation by the decapping/Xrn1 pathway. Whereas certain...

... regulated during meiosis. We have recently deciphered a combinatorial code that can be used to qualitatively and quantitatively predict the translational behaviour of CPE-containing mRNAs. This code defines positive and negative feedback loops that generate waves of polyadenylation and deadenylation...

...H.B. Osborne; C. Gautier-Courteille; A. Graindorge; C. Barreau; Y. Audic; R. Thuret; N. Pollet; L. Paillard EDEN (embryo deadenylation element)-dependent deadenylation is a regulatory process that was initially identified in Xenopus laevis early embryos and was subsequently shown to exist...

... of the mRNA and decreased secretion of the protein. Recent evidence suggests that TTP can accomplish this accelerated mRNA degradation by first promoting removal of the polyadenylated tail from the mRNA (deadenylation). In functional assays in cells, the other family members have similar activities...