... different venoms demonstrate considerable cytotoxic effects on cancer cells via induction of apoptosis, cell cycle arrest and suppression of proliferation. These enzymes produce more pronounced cytotoxic effects in cancer cells than normal cells, thus they can be potential sources as chemotherapeutic agents...

...@abdn.ac.uk ). 10 1 2007 © 2007 The Biochemical Society 2007 chemoprevention colorectal cancer cytotoxicity non-steroidal anti-inflammatory drug (NSAID) polyamine Colorectal cancer is currently the most commonly diagnosed cancer in the European Union. In 2004, there were 376000...

...A. Saudemont; K. Okkenhaug; F. Colucci NK cell (natural killer cells) are lymphocytes of innate immunity that kill tumour cells and respond to infections, without prior stimulation. A balance of activating and inhibitory signals regulates NK cell cytotoxicity, but the molecular mechanisms...

...N. Shangari; W.R. Bruce; R. Poon; P.J. O'Brien Glyoxals are reactive α-oxoaldehydes that are formed endogenously from sugars, the levels of which are increased in various pathological conditions associated with hyperglycaemia and thiamine deficiency. However, the molecular cytotoxic mechanisms...

... proliferation and viability. The assays performed suggested that apoptosis was not the principal cell death mechanism involved in oxa-polyamine cytotoxicity. In contrast, HL-60 cell death induced by the bisnaphthalimido series was characterized by early exposure of phosphatidylserine exclusive from membrane...

...-mail Bengt.Hallberg@cmb.umu.se 11 3 2002 © 2002 Biochemical Society 2002 ADP ribosylation coenzyme-binding site cytotoxicity ExoS, exoenzyme S GST, glutathione S-transferase NADE, p75NTR-associated cell-death executor 14-3-3 Proteins in Cell Regulation 13 14 15 16 17 18 19 20 21 22 23...

... indicated that cancer cells may become enriched in CLA during growth in culture. This may make intracellular lipids more susceptible to ordinary levels of oxidative stress, to the point of producing a cytotoxic effect. © 2001 Biochemical Society 2001 cytotoxicity lipid peroxidation phospholipid...