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Keywords: cytoskeleton
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Articles
Biochem Soc Trans (2022) 50 (5): 1281–1291.
Published: 25 October 2022
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cytoskeleton efferocytosis immune receptors mechanobiology phagocytosis phosphatidylserine In a classical paper by Fadok et al. exposure of phosphatidylserine (PS) was identified as a molecular trigger for clearance...
Articles
Biochem Soc Trans (2022) 50 (5): 1527–1539.
Published: 16 September 2022
...Rogério Lopes dos Santos; Clément Campillo Cell shape changes that are fuelled by the dynamics of the actomyosin cytoskeleton control cellular processes such as motility and division. However, the mechanisms of interplay between cell membranes and actomyosin are complicated to decipher...
Articles
Biochem Soc Trans (2021) 49 (2): 685–692.
Published: 19 March 2021
...Elena E. Grintsevich Drebrin is a key regulator of actin cytoskeleton in neuronal cells which is critical for synaptic plasticity, neuritogenesis, and neuronal migration. It is also known to orchestrate a cross-talk between actin and microtubules. Decreased level of drebrin is a hallmark...
Articles
Biochem Soc Trans (2021) 49 (1): 217–235.
Published: 01 February 2021
.... The abundance of PRK-driven pathologies suggests that these enzymes will be good therapeutic targets and we briefly report some of the progress to date. cytoskeleton phospholipids PKN protein-serine-threonine kinases Rho-associated protein kinases The PRK serine/threonine kinase family comprises...
Articles
Biochem Soc Trans (2020) 48 (4): 1397–1417.
Published: 17 July 2020
... for this article was enabled by the participation of University of Cambridge in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. cytoskeleton nuclear functions p85 phosphoinositide 3-kinase receptor trafficking...
Articles
Biochem Soc Trans (2019) 47 (6): 1621–1634.
Published: 12 December 2019
... for cell shape are therefore the elements of the bacterial cytoskeleton, principally FtsZ, MreB, and the penicillin-binding proteins. MreB is particularly relevant in the transition between rod-like and spherical cell shape as it is often (but not always) lost early in the process. Here we will highlight...
Includes: Supplementary data
Articles
Biochem Soc Trans (2019) 47 (1): 197–207.
Published: 21 December 2018
... contributes to novel diagnostic and therapeutic concepts in PD. Correspondence: Kirsten Harvey ( kirsten.harvey@ucl.ac.uk ) 15 10 2018 13 11 2018 19 11 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cytoskeleton...
Articles
Biochem Soc Trans (2018) 46 (6): 1665–1672.
Published: 22 November 2018
...Claire T. Friel; Julie P. Welburn The Kinesin superfamily is a large group of molecular motors that use the turnover of ATP to regulate their interaction with the microtubule cytoskeleton. The coupled relationship between nucleotide turnover and microtubule binding is harnessed in various ways...
Articles
Biochem Soc Trans (2018) 46 (6): 1653–1663.
Published: 22 November 2018
... on a functional cytoskeleton for many homeostatic processes such as local and long-distance vesicle transport, synaptic plasticity, and dendrites/axons growth and remodeling. Here, we will review the available data linking LRRK2 and the cytoskeleton, and discuss how this may be functionally relevant for the well...
Articles
Biochem Soc Trans (2016) 44 (6): 1709–1716.
Published: 02 December 2016
... to the BH2 domain ( Figure 1A ) [ 11 ]. This region presents high homology to the actin bundling region of Anillin. This particular actin-binding region of Cdc42EP3 is not conserved among Borg proteins; however, other Borg members may bind and/or modulate the actin cytoskeleton by alternative mechanisms...
Articles
Biochem Soc Trans (2016) 44 (6): 1701–1708.
Published: 02 December 2016
... and microtubule dynamics. Not surprisingly, formins are best known as key regulators of the cytoskeleton in a variety of morphogenetic processes. However, mounting evidence implicates several formins in the assembly and organization of actin within and around the nucleus. In addition, actin-independent roles...
Articles
Biochem Soc Trans (2016) 44 (5): 1289–1293.
Published: 19 October 2016
... cytoskeleton tumor cell adhesion vesicle trafficking Metastasis is the leading cause of death in cancer patients [ 1 , 2 ]. The first step of metastasis is considered to be the epithelial-to-mesenchymal transition (EMT) during which epithelial tumor cells acquire a motile phenotype to escape from...
Articles
Biochem Soc Trans (2016) 44 (4): 1026–1034.
Published: 15 August 2016
..., at least one class 2 gene and classes 5, 6, 9, 10, 18 and 19. Although the different myosin isoforms all have specific and non-overlapping roles in the cell, in combination they all contribute to the organization of the actin cytoskeleton, and the shape and phenotype of the cell. Over (or under) expression...
Articles
Biochem Soc Trans (2015) 43 (1): 84–91.
Published: 26 January 2015
... ET, we have shown that baculovirus generates at its rear a fishbone-like array of subsets of branched actin filaments, with an average of only four filaments engaged in pushing at any one time. In both of these studies, the application of ET of negatively stained cytoskeletons for higher filament...
Articles
Biochem Soc Trans (2014) 42 (4): 1206–1210.
Published: 11 August 2014
.... SGs and P-bodies are related to NGs (neuronal granules), which are essential in the localization and control of mRNAs in neurons. Importantly, RNA granules are linked to the cytoskeleton, which plays an important role in mediating many of their dynamic properties. In the present review, we discuss how...
Articles
Biochem Soc Trans (2014) 42 (2): 370–376.
Published: 20 March 2014
... transmembrane protein. Interaction of matching pollen and pistil S -determinants results in self-recognition, initiating a Ca 2+ -dependent signalling network in incompatible pollen. This triggers several downstream events, including alterations to the cytoskeleton, phosphorylation of sPPases (soluble inorganic...
Articles
Biochem Soc Trans (2014) 42 (2): 274–278.
Published: 20 March 2014
... protein directly activated by cAMP). The present review outlines the role of Epac1 signalling within the endothelium and, in particular, the role of Epac1 in cytoskeletal dynamics and the control of cell morphology. The actin/cytoskeleton linker ezrin will be described in terms of the growing body...
Articles
Biochem Soc Trans (2014) 42 (1): 201–205.
Published: 23 January 2014
...Sergio A. Rincón; Miguel Estravís; Pilar Pérez Polarized cell growth requires a well-orchestrated number of events, namely selection of growth site, organization of cytoskeleton elements and delivery of new material to the growth region. The small Rho GTPase Cdc42 has emerged as a major organizer...
Articles
Biochem Soc Trans (2013) 41 (6): 1750–1754.
Published: 20 November 2013
... 2013 Biochemical Society 2013 actin cytokinesis cytoskeleton formin To complete daughter cell separation following mitosis, many well-studied organisms utilize a contractile-based apparatus termed the CR (cytokinetic ring). This structure, which is structurally and functionally based...
Articles
Biochem Soc Trans (2013) 41 (6): 1736–1744.
Published: 20 November 2013
...Jonathan L.D. Lawson; Rafael E. Carazo Salas The post-genomic era has produced a variety of new investigation technologies, techniques and approaches that may offer exciting insights into many long-standing questions of scientific research. The microtubule cytoskeleton is a highly conserved system...
Articles
Biochem Soc Trans (2012) 40 (5): 1117–1122.
Published: 19 September 2012
... role of LRRK2 in the regulation of membrane trafficking from vesicle generation to the movement along cytoskeleton and finally to vesicle fusion with cell membrane. 1 To whom correspondence should be addressed (email ciaccarino@uniss.it ). 2 5 2012 © The Authors Journal...
Articles
Biochem Soc Trans (2012) 40 (5): 1080–1085.
Published: 19 September 2012
... correspondence should be addressed (email javier.alegre@dpag.ox.ac.uk ). 25 6 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 autophagy cytoskeleton dopamine leucine-rich repeat kinase 2 (LRRK2) Parkinson's disease tau Mutations in the LRRK2 (leucine-rich...
Articles
Biochem Soc Trans (2011) 39 (6): 1597–1600.
Published: 21 November 2011
... The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis cell co-culture cytoskeleton endothelial cell fibroblast Matrigel assay Angiogenesis is the process by which new blood vessels form from pre-existing vasculature. Angiogenesis is most active during development...
Articles
Biochem Soc Trans (2010) 38 (3): 729–732.
Published: 24 May 2010
... Honing H.S. Emons A.M.C. Probing cytoplasmic organisation and the actin cytoskeleton of plant cells with optical tweezers Biochem. Soc. Trans. 2010 38 823 828 38 van der Honing H.S. de Ruijter N.C.A. Emons A.M.C. Ketelaar T. Actin and mysoin regulate cytoplasm...
Articles
Biochem Soc Trans (2010) 38 (3): 789–795.
Published: 24 May 2010
.... Mitochondria are highly motile and movement on the cytoskeleton ensures that the physically discrete organelles come into contact with one another, which allows transient fusion, followed by division of the mitochondrial membranes. This article serves to review our current knowledge of mitochondrial fusion...
Articles
Biochem Soc Trans (2010) 38 (3): 747–753.
Published: 24 May 2010
...’. With latrunculin B treatment, we have investigated the involvement of actin in the elongation and persistency of the tubules. We also show how the cytoskeleton is involved in directional diffusion within the membrane. This observation may lead to an answer to the question of what function this network structure...
Articles
Biochem Soc Trans (2008) 36 (6): 1368–1372.
Published: 19 November 2008
... (anchorage 1)/SYNE (synaptic nuclear envelope protein) homology]-domain family, which function primarily as exclusive outer nuclear membrane scaffolds that associate with the cytoskeleton, the centrosome and the motor protein apparatus. In the present paper, we propose a novel model, which may explain why...
Articles
Biochem Soc Trans (2008) 36 (2): 149–155.
Published: 20 March 2008
... in the organization of the actin cytoskeleton. Although cadherins were thought to bind directly to the actin cytoskeleton through cytoplasmic proteins, termed α- and β-catenin, recent studies with purified proteins indicate that the interaction is not direct, and instead an allosteric switch in α-catenin may mediate...
Articles
Biochem Soc Trans (2007) 35 (4): 683–685.
Published: 20 July 2007
...S. Li; V.C. Duance; E.J. Blain The cytoskeleton, which in most cell types, including the intervertebral disc described here, comprises microfilaments, microtubules and intermediate filaments, plays important functions in many fundamental cellular events, including cell division, motility, protein...
Articles
Biochem Soc Trans (2007) 35 (1): 142–145.
Published: 22 January 2007
... expression of MPB2C causes a decrease in the efficiency by which MP spreads between cells and, since this effect is correlated with increased accumulation of MP on microtubules, a role of MPB2C in controlling virus movement by tethering the MP to the cytoskeleton has been proposed [ 22 ]. PAPK resides...
Articles
Biochem Soc Trans (2005) 33 (6): 1295–1298.
Published: 26 October 2005
... to identification of the molecules that initiate the recruitment of presynaptic molecules. However, the mechanisms that regulate the conversion of a growing axon into a presynaptic terminal remain poorly understood. cytoskeleton glycogen synthase kinase-3β (GSK-3β) microtubule synapse © 2005...
Articles
Biochem Soc Trans (2005) 33 (4): 694–697.
Published: 01 August 2005
... the normal maintenance of this tissue: differentiation, migration, proliferation and apoptosis. Indeed, APC is involved in the regulation of β-catenin and it also is an important regulator of the cytoskeleton. Thus mutations in APC lead to the accumulation of β-catenin, which causes changes...
Articles
Biochem Soc Trans (2004) 32 (6): 1113–1114.
Published: 26 October 2004
... 2004 cytoskeleton Dictyostelium motility Nap1 PIR121 suppressor of cAMP receptor (SCAR) The gene encoding PIR121 has been disrupted in Dictyostelium discoideum , which contains highly conserved homologues of SCAR and all the complex members. The resulting PIR121 null mutants...
Articles
Biochem Soc Trans (2004) 32 (5): 878–880.
Published: 26 October 2004
.... 1 To whom correspondence should be addressed (email g.milligan@bio.gla.ac.uk ). 6 6 2004 © 2004 The Biochemical Society 2004 cytoskeleton G-protein G-protein-coupled receptor melanin concentrating hormone opioid plakin Although initially considered to exist...
Articles
Biochem Soc Trans (2004) 32 (5): 822–825.
Published: 26 October 2004
... the contractile cytoskeleton to the plasma membrane, but there is also evidence that integrin receptors modulate signalling events that are essential for cellular differentiation. A major challenge is now to integrate work at the atomic, molecular and cellular levels, and obtain holistic insights...
Articles
Biochem Soc Trans (2004) 32 (5): 831–836.
Published: 26 October 2004
... of such junctions, whereas vinculin appears to be important in regulating adhesion dynamics and cell migration. The integrin family of cell adhesion molecules are coupled to the actin cytoskeleton [ 1 ] with the exception of integrin α6β4, which is linked to the intermediate filament network in hemidesmosomes...
Articles
Biochem Soc Trans (2003) 31 (6): 1209–1212.
Published: 01 December 2003
... 2003 Biochemical Society 2003 cytoskeleton lysophosphatidic acid (LPA) motility phospholipase Rho GTPase Tiam1 Abbreviations used: LPA, lysophosphatidic acid; GPCR, G-protein-coupled receptor; PI 3-kinase, phosphoinositide 3-kinase; EGF, epidermal growth factor; PLD, phospholipase...
Articles
Biochem Soc Trans (2003) 31 (1): 79–82.
Published: 01 February 2003
... envelope or immediately and passively transmitted to the nucleoplasm [3,4]. A number of cell types have provided compelling Key words: cytoskeleton, nucleus. Abbreviations used: ADF; actin depolymerization factor; BAPTA, bis-(o-aminophenoxy)ethane- N,N,N ,N -tetra-acetic acid; CCD, charge-coupled device...
Articles
Biochem Soc Trans (2003) 31 (1): 87–89.
Published: 01 February 2003
...J.D. Scott Targeting of protein kinases and phosphatases to the cytoskeleton enhances the regulation of many signalling events. Cytoskeletal signalling complexes facilitate this process by optimizing the relay of messages from membrane receptors to specific sites on the actin cytoskeleton...
Articles
Biochem Soc Trans (2000) 28 (2): 136–140.
Published: 01 February 2000
... -aminophenoxy)ethane- N,N ,N’,N’-tetra-acetic acid acetoxymethyl ester PKA, protein kinase A PKC, protein kinase C bile formation cholestasis cytoskeleton polarized cells tight junctions Biochemical Society Transactions (2000) Volume 28, part 2 Hepatocyte couplets R. Coleman*' and M. G. Romat...