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Keywords: cytokine signalling
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Biochem Soc Trans (2013) 41 (4): 1042–1047.
Published: 18 July 2013
..., and (ii) inhibiting the activity of JAK after it has been switched on. Whereas the first mode of inhibition is mediated by JAK's own pseudokinase domain as well as the action of phosphatases, the second is achieved by the action of the SOCS (suppressor of cytokine signalling) proteins, negative-feedback...
Biochem Soc Trans (2008) 36 (3): 464–468.
Published: 21 May 2008
...Joanne Elliott; Michelle B. Hookham; James A. Johnston Many studies have suggested that E3 ubiquitin ligases can behave as either oncogenes or tumour suppressor genes and, recently, it has become clear that the SOCS (suppressor of cytokine signalling) E3 ligases fit this mould. While most cancer...