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Keywords: cytochrome p450
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (2): 517–526.
Published: 01 April 2019
... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cholesterol cytochrome p450 Hedgehog Huntington's disease metastasis sterols Oxysterols are oxidised forms of cholesterol or of its...
Includes: Supplementary data
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (1): 183–196.
Published: 06 February 2018
...Andrew W. Munro; Kirsty J. McLean; Job L. Grant; Thomas M. Makris The cytochromes P450 (P450s or CYPs) constitute a large heme enzyme superfamily, members of which catalyze the oxidative transformation of a wide range of organic substrates, and whose functions are crucial to xenobiotic metabolism...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (3): 573–579.
Published: 22 May 2012
.... In the present paper, we review recent genomic and biochemical evidence implicating Mycobacterium tuberculosis CYP (cytochrome P450) enzymes as exciting potential targets for new classes of anti-tuberculars. We also discuss HTS (high-throughput screening) and fragment-based drug-discovery campaigns...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (3): 587–593.
Published: 22 May 2012
... with activities of a number of cytochrome P450 enzymes. These P450s play central critical roles in cholesterol metabolism. Key roles include a rate-limiting reaction in the synthesis of cholesterol itself, and in the oxidative transformations of cholesterol into steroid hormones and bile acids. However, microbial...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 934–939.
Published: 26 July 2010
...Max J. Cryle The cytochromes P450 (P450s) are a superfamily of oxidative haemoproteins that are capable of catalysing a vast range of oxidative transformations, including the oxidation of unactivated alkanes, often with high stereo- and regio-selectivity. Fatty acid hydroxylation by P450s...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 1055–1059.
Published: 19 September 2008
...Benjamin H. Maskrey; Valerie B. O'Donnell Eicosanoids are oxidized arachidonate-derived lipids products generated by lipoxygenase, cyclo-oxygenase and cytochrome P450. Their bioactivity is mediated via receptor-dependent mechanisms and they are involved in a diverse array of processes in both...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1231–1235.
Published: 25 October 2006
... (cytochrome P450) represents a superfamily of enzymes capable of a diverse array of catalytic activities. Distinct members are engaged in biosynthetic reactions within many organisms, while others have a role in the detoxification of foreign compounds. The latter substrates include medicines, pollutants...
Articles
G. Bishop, T. Nomura, T. Yokota, T. Montoya, J. Castle, K. Harrison, T. Kushiro, Y. Kamiya, S. Yamaguchi, S. Bancos, A.-M. Szatmári, M. Szekeres
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1199–1201.
Published: 25 October 2006
... (cytochrome P450) enzymes involved in BR biosynthesis indicates a role for these hormones in plant growth and development. Since the mid-1990s, collaborative research has been geared towards developing a better understanding of the CYP85 class of CYPs involved in BR biosynthesis in both Arabidopsis and tomato...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1161–1164.
Published: 25 October 2006
...G.I. Lepesheva; T.Y. Hargrove; R.D. Ott; W.D. Nes; M.R. Waterman Sterol 14α-demethylases (CYP51) are metabolic cytochromes P450, found in each biological kingdom. They catalyse a single three-step reaction included in all sterol biosynthetic pathways. Plant CYP51s have strict preference towards...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1202–1205.
Published: 25 October 2006
... -sterols containing a double bond at C-22 in the sterol side chain specifically occur in fungi (ergosterol) and plants (stigmasterol and brassicasterol), and several lines of experimental evidence have suggested specific physiological roles of Δ 22 -sterols in plants. Fungal cytochrome P450 (P450), CYP61...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1159–1160.
Published: 25 October 2006
...S.L. Kelly; D.C. Lamb; D.E. Kelly CYP (cytochrome P450) biodiversity and biotechnology is of importance given the industrial applications and potential for the huge array of genes and proteins that can constitute up to 1% of a coding genome. Historical biotechnological roles for CYPs in mutant...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 975–978.
Published: 25 October 2006
... recently, cytochrome P450 cam (the camphor-metabolizing cytochrome P450 from Pseudomonas putida ) has also received considerable interest. In spite of sharing the same prosthetic group, the Fe(II)-haem, these proteins are structurally unrelated and they perform different functions. Recent works show...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1219–1222.
Published: 25 October 2006
.... In human pathogens, particularly Candida albicans , mutations encoding alterations in the target cytochrome P450 sterol 14α-demethylase (CYP51; where CYP is cytochrome P450) enzyme are the primary determinants of triazole resistance. In fungal pathogens of cereals, CYP51A1 modifications, some at positions...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1256–1260.
Published: 25 October 2006
... into the active ecdysteroid of insects, 20E (20-hydroxyecdysone), are mediated by four cytochrome P450 (P450) enzymes, encoded by genes in the Halloween family. Orthologues of the Drosophila Halloween genes phantom ( phm ; CYP306A1 ), disembodied ( dib ; CYP302A1 ), shadow ( sad ; CYP315A1 ) and shade ( shd...
Articles
K.J. McLean, A.J. Dunford, M. Sabri, R. Neeli, H.M. Girvan, P.R. Balding, D. Leys, H.E. Seward, K.R. Marshall, A.W. Munro
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1178–1182.
Published: 25 October 2006
...K.J. McLean; A.J. Dunford; M. Sabri; R. Neeli; H.M. Girvan; P.R. Balding; D. Leys; H.E. Seward; K.R. Marshall; A.W. Munro An extraordinary array of P450 (cytochrome P450) enzymes are encoded on the genome of the human pathogen Mycobacterium tuberculosis (Mtb) and in related mycobacteria...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1183–1185.
Published: 25 October 2006
...Y.-J. Chun; T. Shimada; M.R. Waterman; F.P. Guengerich Streptomyces spp. are known to produce various types of biologically active compounds including antibiotics, antiparasitic agents, herbicides and immunosuppressants. P450 (cytochrome P450) enzymes may have key roles in these biosynthetic...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1192–1198.
Published: 25 October 2006
...J. Ehlting; N.J. Provart; D. Werck-Reichhart Cytochrome P450 mono-oxygenases play prominent roles in a diverse set of metabolic pathways, but the function of most of these enzymes remains obscure. A bottleneck in the functional genomics of this superfamily constitutes hypothesis generation...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1170–1172.
Published: 25 October 2006
...A. Verras; P.R. Ortiz de Montellano P450 (cytochrome P450) enzymes have major roles in the biosynthesis of endogenous factors such as steroids and eicosanoids, in the termination of the action of endogenous factors such as retinoic acid, in the metabolism of most drugs and xenobiotics...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1246–1251.
Published: 25 October 2006
...Y. Wang; A. Al-Gazzar; C. Seibert; A. Sharif; C. Lane; W.J. Griffiths In human, the CYP (cytochrome P450) superfamily comprises 57 genes arranged in 18 families and 42 subfamiles. These genes encode for enzymes involved in the metabolism of drugs, foreign chemicals, fatty acids, eicosanoids...
Articles
K.J. McLean, M. Sabri, K.R. Marshall, R.J. Lawson, D.G. Lewis, D. Clift, P.R. Balding, A.J. Dunford, A.J. Warman, J.P. McVey, A.-M. Quinn, M.J. Sutcliffe, N.S. Scrutton, A.W. Munro
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (4): 796–801.
Published: 01 August 2005
...K.J. McLean; M. Sabri; K.R. Marshall; R.J. Lawson; D.G. Lewis; D. Clift; P.R. Balding; A.J. Dunford; A.J. Warman; J.P. McVey; A.-M. Quinn; M.J. Sutcliffe; N.S. Scrutton; A.W. Munro P450s (cytochrome P450 mono-oxygenases) are a superfamily of haem-containing mono-oxygenase enzymes that participate...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (3): 611–614.
Published: 01 June 2003
... for cytochrome-P450-mediated drug–drug interactions, metabolic stability and assays for toxicology, we have orders of magnitude more data that will facilitate model building. A recursive partitioning model for human liver microsomal metabolic stability based on over 800 structurally diverse molecules was used...
Articles
S. Daff, M. A. Noble, D. H. Craig, S. L. Rivers, S. K. Chapman, A. W. Munro, S. Fujiwara, E. Rozhkova, I. Sagami, T. Shimizu
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (2): 147–152.
Published: 01 May 2001
...S. Daff; M. A. Noble; D. H. Craig; S. L. Rivers; S. K. Chapman; A. W. Munro; S. Fujiwara; E. Rozhkova; I. Sagami; T. Shimizu The nitric oxide synthases (NOSs) are dimeric flavocytochromes consisting of an oxygenase domain with cytochrome P450-like Cys-ligated haem, coupled to a diflavin reductase...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (2): 135–139.
Published: 01 May 2001
... extrapolate to humans. The major drug metabolizing human hepatic cytochrome P450s (CYPs; CYP1A2, 2C9, 2C19, 2D6 and 3A4) have been co-expressed functionally in Escherichia coli with human NADPH-cytochrome P450 reductase and validated as surrogates to their counterparts in human liver microsomes (HLM...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2001) 29 (2): 128–135.
Published: 01 May 2001
... hydrocarbon combinatorial mutagenesis cytochrome P450 shuffling Ah, aryl hydrocarbon CYP, cytochrome P450 PAH, polycyclic aromatic hydrocarbon SRS, substrate-recognition site Biochemical Society Transactions (200 I ) Volume 29, part 2 References I Kalb, V. F., Loper, J. C., Dey, C. R., Woods, C...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (6): 867–870.
Published: 01 December 2000
... R , 10 S enantiomers were incubated separately. We determined respective K m and V max values of 1.2±0.1 μM and 19.2±0.3 nmol/min per nmol of cytochrome P450 for the 9 R , 10 S enantiomer and of 5.9±0.1 μM and 20.2±1.0 nmol/min per nmol of cytochrome P450 for the 9 S , 10 R enantiomer...
