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Keywords: cytochrome c
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Articles
Biochem Soc Trans (2021) 49 (6): 2903–2915.
Published: 08 November 2021
... in the ‘classical’ apoptosis triggering pathway. Cytoplasmic release of cytochrome c (cyt c ), a mitochondrial electron transporter, is a prominent indicator of such critical step. Therefore, visualizing cyt c efflux in living cells is a convenient approach to address apoptosis triggering and monitor performance...
Articles
Biochem Soc Trans (2014) 42 (1): 47–51.
Published: 23 January 2014
... of a cell to apoptosis. However, once downstream events have resulted in the release of cytochrome c to the cytosol, it is widely considered that cell death is inevitable. Cytochrome c may promote its own release from mitochondria through interactions with the mitochondrial phospholipid cardiolipin...
Articles
Biochem Soc Trans (2013) 41 (1): 118–123.
Published: 29 January 2013
... to increased platelet activation in diabetes, Avila et al. [ 6 ] recently showed that platelets from diabetic patients had decreased rates of oxygen consumption and hallmark signs of increased ROS generation. cybrid cytochrome c redox signalling platelet mitochondria The traditional view...
Articles
Biochem Soc Trans (2012) 40 (4): 609–614.
Published: 20 July 2012
... will be highlighted here. On the one hand, TERS measurements on a single mitochondrion are discussed, monitoring the oxidation state of the central iron ion of cytochrome c , leading towards a single protein characterization scheme in a natural environment. On the other hand, a novel approach of single molecule...
Articles
Biochem Soc Trans (2012) 40 (3): 493–500.
Published: 22 May 2012
... To whom correspondence should be addressed (email d.richardson@uea.ac.uk ). 20 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cytochrome c electron paramagnetic resonance (EPR) electron transfer iron respiration protein film voltammetry Shewanella...
Articles
Biochem Soc Trans (2012) 40 (2): 415–418.
Published: 21 March 2012
... cytochrome c CcP cytochrome c peroxidase Mb myoglobin PRE paramagnetic relaxation enhancement RDC residual dipolar coupling This work was financially supported by the Netherlands Organisation for Scientific Research [grant number 700.58.441]. References 1...
Articles
Biochem Soc Trans (2011) 39 (5): 1293–1298.
Published: 21 September 2011
... biochemical, molecular and spectroscopic methods. Recently, we have applied ultrafast 2D-IR (two-dimensional IR) spectroscopy to the analysis of NO–protein interactions using Mb (myoglobin) and Cc (cytochrome c ) as model haem proteins. The ultrafast fluctuations of Cc and Mb show marked differences...
Articles
Biochem Soc Trans (2011) 39 (5): 1538–1543.
Published: 21 September 2011
... achievements in the elucidation of the events leading to PCD that occur as a response to yeast treatment with AA (acetic acid). In particular, ROS (reactive oxygen species) generation, cyt c (cytochrome c ) release and mitochondrial function and proteolytic activity will be dealt with as they vary along the AA...
Articles
Biochem Soc Trans (2008) 36 (6): 1124–1128.
Published: 19 November 2008
...Despoina A.I. Mavridou; Martin Braun; Linda Thöny-Meyer; Julie M. Stevens; Stuart J. Ferguson The CXXCH motif is usually recognized in the bacterial periplasm as a haem attachment site in apocytochromes c . There is evidence that the Escherichia coli Ccm (cytochrome c maturation) system recognizes...
Articles
Biochem Soc Trans (2008) 36 (5): 981–985.
Published: 19 September 2008
...Ajeeta Nyola; Carola Hunte In cellular respiration, cytochrome c transfers electrons from the cytochrome bc 1 complex to cytochrome c oxidase by transiently binding to the membrane proteins. The first X-ray structure of the yeast cytochrome bc 1 complex with bound cytochrome c revealed the general...
Articles
Biochem Soc Trans (2006) 34 (6): 1334–1340.
Published: 25 October 2006
... programmed cell death is prominent. 1 To whom correspondence should be addressed (email carsten.culmsee@cup.uni-muenchen.de ). 19 7 2006 © 2006 The Biochemical Society 2006 apoptosis inducing factor (AIF) Bid caspase cytochrome c mitochondrion programmed cell death...
Articles
Biochem Soc Trans (2006) 34 (6): 1186–1191.
Published: 25 October 2006
... or variant POR and characterized their activities with cytochrome c and P450c17 assays. We have recently completed an extensive study of the range of POR mutations and characterized the mutants/polymorphisms A112V, T139A, M260V, Y456H, A500V, G536R, L562P, R613X, V628I and F643del from sequencing of patient...
Articles
Biochem Soc Trans (2006) 34 (6): 1283–1286.
Published: 25 October 2006
... permeabilization of the outer mitochondrial membrane by forming an inhibitory complex with a protective Bcl-2 family protein, resulting in cytochrome c release in several cell line systems. However, it is unclear how the mitochondrial p53 pathway mediates neuronal apoptosis after cerebral ischaemia. We examined...
Articles
Biochem Soc Trans (2006) 34 (1): 143–145.
Published: 20 January 2006
... The Biochemical Society 2006 active-site channel cytochrome c nitrite reductase NrfA sequence alignment structural alignment The periplasmic cytochrome c nitrite reductase, NrfA, catalyses the 6e − reduction of NO 2 − to NH 4 + during anaerobic respiration in many Gram-negative...
Articles
Biochem Soc Trans (2005) 33 (4): 792–795.
Published: 01 August 2005
... and in vivo studies have provided insight into the function of this protein and into the overall process of cytochrome c biogenesis. © 2005 The Biochemical Society 2005 It has been suggested that radical chemistry may be involved in the function of CcmE. The involvement of a radical has been proposed...
Articles
Biochem Soc Trans (2005) 33 (4): 724–727.
Published: 01 August 2005
... apoptosis carbonic anhydrase cell cycle coxib cytochrome c NAG-1 (non-steroidal anti-inflammatory drug-activated gene) Cancer prevention, at present a better option than cancer treatment, is entering an era when it appears to be a realistic possibility. The seminal epidemiological observation...
Articles
Biochem Soc Trans (2005) 33 (4): 829–831.
Published: 01 August 2005
...J. Salje; B. Ludwig; O.-M.H. Richter Despite the existence of several three-dimensional structures of cytochrome c oxidases, a detailed understanding of pathways involved in proton movements through the complex remains largely elusive. Next to the two well-established pathways (termed D and K...
Articles
Biochem Soc Trans (2005) 33 (1): 149–151.
Published: 01 February 2005
... cytochrome c maturation in Bacillus subtilis with particular emphasis on the crystal structures of ResA. The crystal structure of a soluble, functional, domain of ResA has been determined in both oxidized and reduced redox states [ 6 ]. ResA has a thioredoxin-like fold with two insertions ( Figure 2 ). A β...
Articles
Biochem Soc Trans (2005) 33 (1): 137–140.
Published: 01 February 2005
... c haem magnetic CD (MCD) nitrite reductase oxidoreductase protein-film voltammetry (PFV) Bacterial nitrite reduction can be coupled with energy conservation by three distinct types of enzyme: cytochrome cd 1 nitrite reductases, copper nitrite reductases and cytochrome c nitrite...
Articles
Biochem Soc Trans (2004) 32 (6): 1078–1080.
Published: 26 October 2004
... in cell and mitochondrial membrane. 1 To whom correspondence should be addressed (email paul@mail.ncku.edu.tw ). 23 7 2004 © 2004 The Biochemical Society 2004 apoptosis cyclo-oxygenase cytochrome c mitochondrion prostaglandin receptor Research Colloquia: Research...
Articles
Biochem Soc Trans (2003) 31 (6): 1312–1315.
Published: 01 December 2003
...M.O. Pereverzev; T.V. Vygodina; A.A. Konstantinov; V.P. Skulachev Generation of Δψ (membrane potential) by cytochrome oxidase proteoliposomes oxidizing superoxide-reduced cytochrome c has been demonstrated. XO+HX (xanthine oxidase and hypoxanthine) were used to produce superoxide. It was found...
Articles
Biochem Soc Trans (2003) 31 (3): 502–505.
Published: 01 June 2003
...: autoinhibition, calmodulin, cytochrome c, electron transfer, nitric oxide, reductase domain. Abbreviations used: NOS, nitric oxide synthase; nNOS, iNOS, eNOS, neuronal, induced and endothelial NOS respectively; nNOSrd, nNOS reductase domain; nNOStr, nNOS truncation mutant; H4B, (6R)-5,6,7,8-tetrahydro-l...
Articles
Biochem Soc Trans (2002) 30 (4): 638–642.
Published: 01 August 2002
... a.hemmings@uea.ac.uk ) 1 Present address: Department of Biochemistry, University of Oxford, Oxford OX1 3QU, U.K. 21 3 2002 © 2002 Biochemical Society 2002 cytochrome c electron transfer SoxAX complex Biochemical Society Transactions (2002) Volume 30, part 4 39 40 41 42 43...
Articles
Biochem Soc Trans (2000) 28 (2): 56–61.
Published: 01 February 2000
... is required for the damage-induced mitochondrial pathway. This is suggested by the finding that the depletion of glutathione, a common event in damage-induced apoptosis, is necessary and sufficient to induce cytochrome c release, the key event of this pathway. A model is proposed with GSH efflux...
Articles
Biochem Soc Trans (2000) 28 (2): 164–169.
Published: 01 February 2000
... as a prerequisite for the action of ADP shuttles via creatine kinases or adenylate kinases. If the outer membrane becomes leaky, cytochrome c and apoptosis-inducing factor can be released, leading to apoptosis, and as a bioenergetic consequence the cytosolic phosphorylation potential decreases. Leaky outer...
Articles
Biochem Soc Trans (2000) 28 (2): 170–177.
Published: 01 February 2000
... MPTP opening directly. Recovery of hearts correlates with subsequent closure, and agents that prevent opening or enhance closure protect from injury. Transient MPTP opening may also be involved in apoptosis by initially causing swelling and rupture of the outer membrane to release cytochrome c (cyt c...