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Articles

Sometimes less is more: inhibitory infrared light during early reperfusion calms hyperactive mitochondria and suppresses reperfusion injury

Paul T. Morse, Junmei Wan, Jamie Bell, Icksoo Lee, Dennis J. Goebel, Moh H. Malek, Thomas H. Sanderson, Maik Hüttemann

Biochem Soc Trans (2022) 50 (5): 1377–1388.

DOI: https://doi.org/10.1042/BST20220446

Published: 06 September 2022

.... This review covers the relationship between the mitochondrial membrane potential (ΔΨ m ) and ROS production. We also discuss physiological mechanisms that couple mitochondrial energy production to cellular energy demand, focusing on serine 47 dephosphorylation of cytochrome c (Cyt c ) in the brain during...

View article titled, Sometimes less is more: inhibitory infrared light during early reperfusion calms hyperactive mitochondria and suppresses reperfusion injury

Articles

Live-cell visualization of cytochrome c : a tool to explore apoptosis

João Pessoa

Biochem Soc Trans (2021) 49 (6): 2903–2915.

DOI: https://doi.org/10.1042/BST20211028

Published: 08 November 2021

... in the ‘classical’ apoptosis triggering pathway. Cytoplasmic release of cytochrome c (cyt c ), a mitochondrial electron transporter, is a prominent indicator of such critical step. Therefore, visualizing cyt c efflux in living cells is a convenient approach to address apoptosis triggering and monitor performance...

View article titled, Live-cell visualization of cytochrome c : a tool to explore apoptosis

Articles

Explorations of time and electrochemical potential: opportunities for fresh perspectives on signalling proteins

Julea N. Butt

Biochem Soc Trans (2014) 42 (1): 47–51.

DOI: https://doi.org/10.1042/BST20130256

Published: 23 January 2014

... of a cell to apoptosis. However, once downstream events have resulted in the release of cytochrome c to the cytosol, it is widely considered that cell death is inevitable. Cytochrome c may promote its own release from mitochondria through interactions with the mitochondrial phospholipid cardiolipin...

View article titled, Explorations of time and electrochemical potential: opportunities for fresh perspectives on signalling proteins

Articles

Platelet mitochondrial function: from regulation of thrombosis to biomarker of disease

Sergey Zharikov, Sruti Shiva

Biochem Soc Trans (2013) 41 (1): 118–123.

DOI: https://doi.org/10.1042/BST20120327

Published: 29 January 2013

.... Tendi E.A. Murri L. Rapoport S.I. Solaini G. Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease Neurobiol. Aging 2002 23 371 376 36 Krige D. Carroll M.T. Cooper J.M. Marsden...

View article titled, Platelet mitochondrial function: from regulation of thrombosis to biomarker of disease

Articles

Advances in TERS (tip-enhanced Raman scattering) for biochemical applications

Regina Treffer, René Böhme, Tanja Deckert-Gaudig, Katherine Lau, Stephan Tiede, Xiumei Lin, Volker Deckert

Biochem Soc Trans (2012) 40 (4): 609–614.

DOI: https://doi.org/10.1042/BST20120033

Published: 20 July 2012

... will be highlighted here. On the one hand, TERS measurements on a single mitochondrion are discussed, monitoring the oxidation state of the central iron ion of cytochrome c , leading towards a single protein characterization scheme in a natural environment. On the other hand, a novel approach of single molecule...

View article titled, Advances in TERS (tip-enhanced Raman scattering) for biochemical applications

Articles

Exploring the biochemistry at the extracellular redox frontier of bacterial mineral Fe(III) respiration

David J. Richardson, Marcus J. Edwards, Gaye F. White, Nanakow Baiden, Robert S. Hartshorne, Jim Fredrickson, Liang Shi, John Zachara, Andrew J. Gates, Julea N. Butt, Thomas A. Clarke

Biochem Soc Trans (2012) 40 (3): 493–500.

DOI: https://doi.org/10.1042/BST20120018

Published: 22 May 2012

... To whom correspondence should be addressed (email d.richardson@uea.ac.uk ). 20 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cytochrome c electron paramagnetic resonance (EPR) electron transfer iron respiration protein film voltammetry Shewanella...

View article titled, Exploring the biochemistry at the extracellular redox frontier of bacterial mineral Fe(III) respiration

Articles

Dynamics in transient complexes of redox proteins

Marcellus Ubbink

Biochem Soc Trans (2012) 40 (2): 415–418.

DOI: https://doi.org/10.1042/BST20110698

Published: 21 March 2012

... can be clearly seen in Figure 2 (A), with 95% of Cc covering a mere 15% of the CcP surface. cytochrome c dynamics myoglobin redox protein Protein complex formation is a complicated process with a very small success rate. To form a specific complex, protein must bind in a defined...

View article titled, Dynamics in transient complexes of redox proteins

Articles

Spectroscopic analysis of protein Fe–NO complexes

César Bellota-Antón, John Munnoch, Kirsty Robb, Katrin Adamczyk, Marco Candelaresi, Anthony W. Parker, Ray Dixon, Matthew I. Hutchings, Neil T. Hunt, Nicholas P. Tucker

Biochem Soc Trans (2011) 39 (5): 1293–1298.

DOI: https://doi.org/10.1042/BST0391293

Published: 21 September 2011

... biochemical, molecular and spectroscopic methods. Recently, we have applied ultrafast 2D-IR (two-dimensional IR) spectroscopy to the analysis of NO–protein interactions using Mb (myoglobin) and Cc (cytochrome c ) as model haem proteins. The ultrafast fluctuations of Cc and Mb show marked differences...

View article titled, Spectroscopic analysis of protein Fe–NO complexes

Articles

Achievements and perspectives in yeast acetic acid-induced programmed cell death pathways

Nicoletta Guaragnella, Lucia Antonacci, Salvatore Passarella, Ersilia Marra, Sergio Giannattasio

Biochem Soc Trans (2011) 39 (5): 1538–1543.

DOI: https://doi.org/10.1042/BST0391538

Published: 21 September 2011

... achievements in the elucidation of the events leading to PCD that occur as a response to yeast treatment with AA (acetic acid). In particular, ROS (reactive oxygen species) generation, cyt c (cytochrome c ) release and mitochondrial function and proteolytic activity will be dealt with as they vary along the AA...

View article titled, Achievements and perspectives in yeast acetic acid-induced programmed cell death pathways

Articles

Avoidance of the cytochrome c biogenesis system by periplasmic CXXCH motifs

Despoina A.I. Mavridou, Martin Braun, Linda Thöny-Meyer, Julie M. Stevens, Stuart J. Ferguson

Biochem Soc Trans (2008) 36 (6): 1124–1128.

DOI: https://doi.org/10.1042/BST0361124

Published: 19 November 2008

...Despoina A.I. Mavridou; Martin Braun; Linda Thöny-Meyer; Julie M. Stevens; Stuart J. Ferguson The CXXCH motif is usually recognized in the bacterial periplasm as a haem attachment site in apocytochromes c . There is evidence that the Escherichia coli Ccm (cytochrome c maturation) system recognizes...

View article titled, Avoidance of the cytochrome c biogenesis system by periplasmic CXXCH motifs

Articles

A structural analysis of the transient interaction between the cytochrome bc 1 complex and its substrate cytochrome c

Ajeeta Nyola, Carola Hunte

Biochem Soc Trans (2008) 36 (5): 981–985.

DOI: https://doi.org/10.1042/BST0360981

Published: 19 September 2008

...Ajeeta Nyola; Carola Hunte In cellular respiration, cytochrome c transfers electrons from the cytochrome bc 1 complex to cytochrome c oxidase by transiently binding to the membrane proteins. The first X-ray structure of the yeast cytochrome bc 1 complex with bound cytochrome c revealed the general...

View article titled, A structural analysis of the transient interaction between the cytochrome bc 1 complex and its substrate cytochrome c

Articles

Targeting Bid to prevent programmed cell death in neurons

C. Culmsee, N. Plesnila

Biochem Soc Trans (2006) 34 (6): 1334–1340.

DOI: https://doi.org/10.1042/BST0341334

Published: 25 October 2006

... programmed cell death is prominent. 1 To whom correspondence should be addressed (email carsten.culmsee@cup.uni-muenchen.de ). 19 7 2006 © 2006 The Biochemical Society 2006 apoptosis inducing factor (AIF) Bid caspase cytochrome c mitochondrion programmed cell death...

View article titled, Targeting Bid to prevent programmed cell death in neurons

Articles

Biochemical analysis of mutations in P450 oxidoreductase

A.V. Pandey

Biochem Soc Trans (2006) 34 (6): 1186–1191.

DOI: https://doi.org/10.1042/BST0341186

Published: 25 October 2006

... or variant POR and characterized their activities with cytochrome c and P450c17 assays. We have recently completed an extensive study of the range of POR mutations and characterized the mutants/polymorphisms A112V, T139A, M260V, Y456H, A500V, G536R, L562P, R613X, V628I and F643del from sequencing of patient...

View article titled, Biochemical analysis of mutations in P450 oxidoreductase

Articles

Mitochondrial translocation of p53 underlies the selective death of hippocampal CA1 neurons after global cerebral ischaemia

H. Endo, A. Saito, P.H. Chan

Biochem Soc Trans (2006) 34 (6): 1283–1286.

DOI: https://doi.org/10.1042/BST0341283

Published: 25 October 2006

... permeabilization of the outer mitochondrial membrane by forming an inhibitory complex with a protective Bcl-2 family protein, resulting in cytochrome c release in several cell line systems. However, it is unclear how the mitochondrial p53 pathway mediates neuronal apoptosis after cerebral ischaemia. We examined...

View article titled, Mitochondrial translocation of p53 underlies the selective death of hippocampal CA1 neurons after global cerebral ischaemia

Articles

Comparison of the structural and kinetic properties of the cytochrome c nitrite reductases from Escherichia coli , Wolinella succinogenes , Sulfurospirillum deleyianum and Desulfovibrio desulfuricans

T.A. Clarke, A.M. Hemmings, B. Burlat, J.N. Butt, J.A. Cole, D.J. Richardson

Biochem Soc Trans (2006) 34 (1): 143–145.

DOI: https://doi.org/10.1042/BST0340143

Published: 20 January 2006

... The Biochemical Society 2006 active-site channel cytochrome c nitrite reductase NrfA sequence alignment structural alignment The periplasmic cytochrome c nitrite reductase, NrfA, catalyses the 6e − reduction of NO 2 − to NH 4 + during anaerobic respiration in many Gram-negative...

View article titled, Comparison of the structural and kinetic properties of the cytochrome c nitrite reductases from Escherichia coli , Wolinella succinogenes , Sulfurospirillum deleyianum and Desulfovibrio desulfuricans

Articles

Covalent cofactor attachment to proteins: cytochrome c biogenesis

J.M. Stevens, T. Uchida, O. Daltrop, S.J. Ferguson

Biochem Soc Trans (2005) 33 (4): 792–795.

DOI: https://doi.org/10.1042/BST0330792

Published: 01 August 2005

... and in vivo studies have provided insight into the function of this protein and into the overall process of cytochrome c biogenesis. 1 To whom correspondence should be addressed (email julie.stevens@bioch.ox.ac.uk ). 5 4 2005 © 2005 The Biochemical Society 2005 CcmE chaperone...

View article titled, Covalent cofactor attachment to proteins: cytochrome c biogenesis

Articles

Is COX-2 a ‘collateral’ target in cancer prevention?

K. Kashfi, B. Rigas

Biochem Soc Trans (2005) 33 (4): 724–727.

DOI: https://doi.org/10.1042/BST0330724

Published: 01 August 2005

... apoptosis carbonic anhydrase cell cycle coxib cytochrome c NAG-1 (non-steroidal anti-inflammatory drug-activated gene) The initial response of many investigators, including ourselves, to the epidemiological data showing that NSAIDs are associated with a decreased incidence of cancer...

View article titled, Is COX-2 a ‘collateral’ target in cancer prevention?

Articles

Is a third proton-conducting pathway operative in bacterial cytochrome c oxidase?

J. Salje, B. Ludwig, O.-M.H. Richter

Biochem Soc Trans (2005) 33 (4): 829–831.

DOI: https://doi.org/10.1042/BST0330829

Published: 01 August 2005

...J. Salje; B. Ludwig; O.-M.H. Richter Despite the existence of several three-dimensional structures of cytochrome c oxidases, a detailed understanding of pathways involved in proton movements through the complex remains largely elusive. Next to the two well-established pathways (termed D and K...

View article titled, Is a third proton-conducting pathway operative in bacterial cytochrome c oxidase?

Articles

Cytochrome c nitrite reductase: from structural to physicochemical analysis

B. Burlat, J.D. Gwyer, S. Poock, T. Clarke, J.A. Cole, A.M. Hemmings, M.R. Cheesman, J.N. Butt, D.J. Richardson

Biochem Soc Trans (2005) 33 (1): 137–140.

DOI: https://doi.org/10.1042/BST0330137

Published: 01 February 2005

.... Dev. Biochem. 2003 4 159 180 1 To whom correspondence should be addressed (email b.burlat@uea.ac.uk ). 18 10 2004 © 2005 The Biochemical Society 2005 cytochrome c haem magnetic CD (MCD) nitrite reductase oxidoreductase protein-film voltammetry (PFV...

View article titled, Cytochrome c nitrite reductase: from structural to physicochemical analysis

Articles

The role of ResA in type II cytochrome c maturation

A. Crow, N.E. Le Brun, A. Oubrie

Biochem Soc Trans (2005) 33 (1): 149–151.

DOI: https://doi.org/10.1042/BST0330149

Published: 01 February 2005

... cytochrome c maturation in Bacillus subtilis with particular emphasis on the crystal structures of ResA. 1 To whom correspondence should be addressed (email a.oubrie@uea.ac.uk ). 15 9 2004 © 2005 The Biochemical Society 2005 cytochrome c disulphide Gram-positive haem...

View article titled, The role of ResA in type II cytochrome c maturation

Articles

Study of prostaglandin receptors in mitochondria on apoptosis of human lung carcinoma cell line A549

K.M. Fang, W.H. Shu, H.C. Chang, J.J. Wang, O.T. Mak

Biochem Soc Trans (2004) 32 (6): 1078–1080.

DOI: https://doi.org/10.1042/BST0321078

Published: 26 October 2004

... in cell and mitochondrial membrane. 1 To whom correspondence should be addressed (email paul@mail.ncku.edu.tw ). 23 7 2004 © 2004 The Biochemical Society 2004 apoptosis cyclo-oxygenase cytochrome c mitochondrion prostaglandin receptor Research Colloquia: Research...

View article titled, Study of prostaglandin receptors in mitochondria on apoptosis of human lung carcinoma cell line A549

Articles

Cytochrome c, an ideal antioxidant

M.O. Pereverzev, T.V. Vygodina, A.A. Konstantinov, V.P. Skulachev

Biochem Soc Trans (2003) 31 (6): 1312–1315.

DOI: https://doi.org/10.1042/bst0311312

Published: 01 December 2003

...M.O. Pereverzev; T.V. Vygodina; A.A. Konstantinov; V.P. Skulachev Generation of Δψ (membrane potential) by cytochrome oxidase proteoliposomes oxidizing superoxide-reduced cytochrome c has been demonstrated. XO+HX (xanthine oxidase and hypoxanthine) were used to produce superoxide. It was found...

View article titled, Cytochrome c, an ideal antioxidant

Articles

Calmodulin-dependent regulation of mammalian nitric oxide synthase

S. Daff

Biochem Soc Trans (2003) 31 (3): 502–505.

DOI: https://doi.org/10.1042/bst0310502

Published: 01 June 2003

...: autoinhibition, calmodulin, cytochrome c, electron transfer, nitric oxide, reductase domain. Abbreviations used: NOS, nitric oxide synthase; nNOS, iNOS, eNOS, neuronal, induced and endothelial NOS respectively; nNOSrd, nNOS reductase domain; nNOStr, nNOS truncation mutant; H4B, (6R)-5,6,7,8-tetrahydro-l...

View article titled, Calmodulin-dependent regulation of mammalian nitric oxide synthase

Articles

Novel domain packing in the crystal structure of a thiosulphate-oxidizing enzyme

V. A. Bamford, B. C. Berks, A. M. Hemmings

Biochem Soc Trans (2002) 30 (4): 638–642.

DOI: https://doi.org/10.1042/bst0300638

Published: 01 August 2002

... haemoproteins where both partners adopt the c -type cytochrome fold. The packing of c -type cytochrome domains both within SoxA and at the interface between the subunits of the complex has been compared with other examples and found to be unique. cytochrome c electron transfer SoxAX complex 2...

View article titled, Novel domain packing in the crystal structure of a thiosulphate-oxidizing enzyme

Articles

GSH extrusion and the mitochondrial pathway of apoptotic signalling

S. Coppola, L. Ghibelli

Biochem Soc Trans (2000) 28 (2): 56–61.

DOI: https://doi.org/10.1042/bst0280056

Published: 01 February 2000

... is required for the damage-induced mitochondrial pathway. This is suggested by the finding that the depletion of glutathione, a common event in damage-induced apoptosis, is necessary and sufficient to induce cytochrome c release, the key event of this pathway. A model is proposed with GSH efflux...

View article titled, GSH extrusion and the mitochondrial pathway of apoptotic signalling

Articles

Function of the mitochondrial outer membrane as a diffusion barrier in health and diseases

F. N. Gellerich, S. Trumbeckaite, J. R. Opalka, E. Seppet, H. N. Rasmussen, C. Neuhoff, S. Zierz

Biochem Soc Trans (2000) 28 (2): 164–169.

DOI: https://doi.org/10.1042/bst0280164

Published: 01 February 2000

... as a prerequisite for the action of ADP shuttles via creatine kinases or adenylate kinases. If the outer membrane becomes leaky, cytochrome c and apoptosis-inducing factor can be released, leading to apoptosis, and as a bioenergetic consequence the cytosolic phosphorylation potential decreases. Leaky outer...

View article titled, Function of the mitochondrial outer membrane as a diffusion barrier in health and diseases

Articles

Mitochondria and cell death

A. P. Halestrap, E. Doran, J. P. Gillespie, A. O'Toole

Biochem Soc Trans (2000) 28 (2): 170–177.

DOI: https://doi.org/10.1042/bst0280170

Published: 01 February 2000

... MPTP opening directly. Recovery of hearts correlates with subsequent closure, and agents that prevent opening or enhance closure protect from injury. Transient MPTP opening may also be involved in apoptosis by initially causing swelling and rupture of the outer membrane to release cytochrome c (cyt c...

View article titled, Mitochondria and cell death

NARROW

Sometimes less is more: inhibitory infrared light during early reperfusion calms hyperactive mitochondria and suppresses reperfusion injury

Live-cell visualization of cytochrome c : a tool to explore apoptosis

Explorations of time and electrochemical potential: opportunities for fresh perspectives on signalling proteins

Platelet mitochondrial function: from regulation of thrombosis to biomarker of disease

Advances in TERS (tip-enhanced Raman scattering) for biochemical applications

Exploring the biochemistry at the extracellular redox frontier of bacterial mineral Fe(III) respiration

Dynamics in transient complexes of redox proteins

Spectroscopic analysis of protein Fe–NO complexes

Achievements and perspectives in yeast acetic acid-induced programmed cell death pathways

Avoidance of the cytochrome c biogenesis system by periplasmic CXXCH motifs

A structural analysis of the transient interaction between the cytochrome bc 1 complex and its substrate cytochrome c

Targeting Bid to prevent programmed cell death in neurons

Biochemical analysis of mutations in P450 oxidoreductase

Mitochondrial translocation of p53 underlies the selective death of hippocampal CA1 neurons after global cerebral ischaemia

Comparison of the structural and kinetic properties of the cytochrome c nitrite reductases from Escherichia coli , Wolinella succinogenes , Sulfurospirillum deleyianum and Desulfovibrio desulfuricans

Covalent cofactor attachment to proteins: cytochrome c biogenesis

Is COX-2 a ‘collateral’ target in cancer prevention?

Is a third proton-conducting pathway operative in bacterial cytochrome c oxidase?

Cytochrome c nitrite reductase: from structural to physicochemical analysis

The role of ResA in type II cytochrome c maturation

Study of prostaglandin receptors in mitochondria on apoptosis of human lung carcinoma cell line A549

Cytochrome c, an ideal antioxidant

Calmodulin-dependent regulation of mammalian nitric oxide synthase

Novel domain packing in the crystal structure of a thiosulphate-oxidizing enzyme

GSH extrusion and the mitochondrial pathway of apoptotic signalling

Function of the mitochondrial outer membrane as a diffusion barrier in health and diseases

Mitochondria and cell death

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