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Keywords: cytochrome c
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Biochem Soc Trans (2021) 49 (6): 2903–2915.
Published: 08 November 2021
... in the ‘classical’ apoptosis triggering pathway. Cytoplasmic release of cytochrome c (cyt c ), a mitochondrial electron transporter, is a prominent indicator of such critical step. Therefore, visualizing cyt c efflux in living cells is a convenient approach to address apoptosis triggering and monitor performance...
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Biochem Soc Trans (2014) 42 (1): 47–51.
Published: 23 January 2014
... of a cell to apoptosis. However, once downstream events have resulted in the release of cytochrome c to the cytosol, it is widely considered that cell death is inevitable. Cytochrome c may promote its own release from mitochondria through interactions with the mitochondrial phospholipid cardiolipin...
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Biochem Soc Trans (2013) 41 (1): 118–123.
Published: 29 January 2013
.... Tendi E.A. Murri L. Rapoport S.I. Solaini G. Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease Neurobiol. Aging 2002 23 371 376 36 Krige D. Carroll M.T. Cooper J.M. Marsden...
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Biochem Soc Trans (2012) 40 (4): 609–614.
Published: 20 July 2012
... will be highlighted here. On the one hand, TERS measurements on a single mitochondrion are discussed, monitoring the oxidation state of the central iron ion of cytochrome c , leading towards a single protein characterization scheme in a natural environment. On the other hand, a novel approach of single molecule...
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Biochem Soc Trans (2012) 40 (2): 415–418.
Published: 21 March 2012
... can be clearly seen in Figure 2 (A), with 95% of Cc covering a mere 15% of the CcP surface. cytochrome c dynamics myoglobin redox protein Protein complex formation is a complicated process with a very small success rate. To form a specific complex, protein must bind in a defined...
Articles
Biochem Soc Trans (2011) 39 (5): 1293–1298.
Published: 21 September 2011
... biochemical, molecular and spectroscopic methods. Recently, we have applied ultrafast 2D-IR (two-dimensional IR) spectroscopy to the analysis of NO–protein interactions using Mb (myoglobin) and Cc (cytochrome c ) as model haem proteins. The ultrafast fluctuations of Cc and Mb show marked differences...
Articles
Biochem Soc Trans (2011) 39 (5): 1538–1543.
Published: 21 September 2011
... achievements in the elucidation of the events leading to PCD that occur as a response to yeast treatment with AA (acetic acid). In particular, ROS (reactive oxygen species) generation, cyt c (cytochrome c ) release and mitochondrial function and proteolytic activity will be dealt with as they vary along the AA...
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Biochem Soc Trans (2006) 34 (6): 1334–1340.
Published: 25 October 2006
... programmed cell death is prominent. 1 To whom correspondence should be addressed (email carsten.culmsee@cup.uni-muenchen.de ). 19 7 2006 © 2006 The Biochemical Society 2006 apoptosis inducing factor (AIF) Bid caspase cytochrome c mitochondrion programmed cell death...
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Biochem Soc Trans (2006) 34 (6): 1186–1191.
Published: 25 October 2006
... or variant POR and characterized their activities with cytochrome c and P450c17 assays. We have recently completed an extensive study of the range of POR mutations and characterized the mutants/polymorphisms A112V, T139A, M260V, Y456H, A500V, G536R, L562P, R613X, V628I and F643del from sequencing of patient...
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Biochem Soc Trans (2006) 34 (6): 1283–1286.
Published: 25 October 2006
... permeabilization of the outer mitochondrial membrane by forming an inhibitory complex with a protective Bcl-2 family protein, resulting in cytochrome c release in several cell line systems. However, it is unclear how the mitochondrial p53 pathway mediates neuronal apoptosis after cerebral ischaemia. We examined...
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Biochem Soc Trans (2005) 33 (4): 792–795.
Published: 01 August 2005
... and in vivo studies have provided insight into the function of this protein and into the overall process of cytochrome c biogenesis. 1 To whom correspondence should be addressed (email julie.stevens@bioch.ox.ac.uk ). 5 4 2005 © 2005 The Biochemical Society 2005 CcmE chaperone...
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Biochem Soc Trans (2005) 33 (4): 724–727.
Published: 01 August 2005
... apoptosis carbonic anhydrase cell cycle coxib cytochrome c NAG-1 (non-steroidal anti-inflammatory drug-activated gene) The initial response of many investigators, including ourselves, to the epidemiological data showing that NSAIDs are associated with a decreased incidence of cancer...
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Biochem Soc Trans (2005) 33 (4): 829–831.
Published: 01 August 2005
...J. Salje; B. Ludwig; O.-M.H. Richter Despite the existence of several three-dimensional structures of cytochrome c oxidases, a detailed understanding of pathways involved in proton movements through the complex remains largely elusive. Next to the two well-established pathways (termed D and K...
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Biochem Soc Trans (2005) 33 (1): 149–151.
Published: 01 February 2005
... cytochrome c maturation in Bacillus subtilis with particular emphasis on the crystal structures of ResA. 1 To whom correspondence should be addressed (email a.oubrie@uea.ac.uk ). 15 9 2004 © 2005 The Biochemical Society 2005 cytochrome c disulphide Gram-positive haem...
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Biochem Soc Trans (2004) 32 (6): 1078–1080.
Published: 26 October 2004
... in cell and mitochondrial membrane. 1 To whom correspondence should be addressed (email paul@mail.ncku.edu.tw ). 23 7 2004 © 2004 The Biochemical Society 2004 apoptosis cyclo-oxygenase cytochrome c mitochondrion prostaglandin receptor Research Colloquia: Research...
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Biochem Soc Trans (2003) 31 (6): 1312–1315.
Published: 01 December 2003
...M.O. Pereverzev; T.V. Vygodina; A.A. Konstantinov; V.P. Skulachev Generation of Δψ (membrane potential) by cytochrome oxidase proteoliposomes oxidizing superoxide-reduced cytochrome c has been demonstrated. XO+HX (xanthine oxidase and hypoxanthine) were used to produce superoxide. It was found...
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Biochem Soc Trans (2003) 31 (3): 502–505.
Published: 01 June 2003
...: autoinhibition, calmodulin, cytochrome c, electron transfer, nitric oxide, reductase domain. Abbreviations used: NOS, nitric oxide synthase; nNOS, iNOS, eNOS, neuronal, induced and endothelial NOS respectively; nNOSrd, nNOS reductase domain; nNOStr, nNOS truncation mutant; H4B, (6R)-5,6,7,8-tetrahydro-l...
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Biochem Soc Trans (2002) 30 (4): 638–642.
Published: 01 August 2002
... haemoproteins where both partners adopt the c -type cytochrome fold. The packing of c -type cytochrome domains both within SoxA and at the interface between the subunits of the complex has been compared with other examples and found to be unique. cytochrome c electron transfer SoxAX complex 2...
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Biochem Soc Trans (2000) 28 (2): 56–61.
Published: 01 February 2000
... is required for the damage-induced mitochondrial pathway. This is suggested by the finding that the depletion of glutathione, a common event in damage-induced apoptosis, is necessary and sufficient to induce cytochrome c release, the key event of this pathway. A model is proposed with GSH efflux...
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Biochem Soc Trans (2000) 28 (2): 164–169.
Published: 01 February 2000
... as a prerequisite for the action of ADP shuttles via creatine kinases or adenylate kinases. If the outer membrane becomes leaky, cytochrome c and apoptosis-inducing factor can be released, leading to apoptosis, and as a bioenergetic consequence the cytosolic phosphorylation potential decreases. Leaky outer...
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Biochem Soc Trans (2000) 28 (2): 170–177.
Published: 01 February 2000
... MPTP opening directly. Recovery of hearts correlates with subsequent closure, and agents that prevent opening or enhance closure protect from injury. Transient MPTP opening may also be involved in apoptosis by initially causing swelling and rupture of the outer membrane to release cytochrome c (cyt c...