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Keywords: cytochrome c
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Articles

Regulation of electron transfer in the terminal step of the respiratory chain

Wataru Sato, Koichiro Ishimori
Journal: Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1611–1619.
https://doi.org/10.1042/BST20221449
Published: 06 July 2023
... by the reduction in molecular oxygen at Complex IV, cytochrome c oxidase (C c O) that is coupled with the proton pumping from the matrix to the inner membrane space. Unlike the ET reactions from Complex I to Complex III, the ET reaction to C c O, mediated by cytochrome c (Cyt c ), is quite specific...
View article titled, Regulation of electron transfer in the terminal step of the respiratory chain
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Articles

Sometimes less is more: inhibitory infrared light during early reperfusion calms hyperactive mitochondria and suppresses reperfusion injury

Paul T. Morse, Junmei Wan, Jamie Bell, Icksoo Lee, Dennis J. Goebel, Moh H. Malek, Thomas H. Sanderson, Maik Hüttemann
Journal: Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1377–1388.
https://doi.org/10.1042/BST20220446
Published: 06 September 2022
.... This review covers the relationship between the mitochondrial membrane potential (ΔΨ m ) and ROS production. We also discuss physiological mechanisms that couple mitochondrial energy production to cellular energy demand, focusing on serine 47 dephosphorylation of cytochrome c (Cyt c ) in the brain during...
View article titled, Sometimes less is more: inhibitory infrared light during early reperfusion calms hyperactive mitochondria and suppresses reperfusion injury
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Articles

Live-cell visualization of cytochrome c : a tool to explore apoptosis

João Pessoa
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2903–2915.
https://doi.org/10.1042/BST20211028
Published: 08 November 2021
... in the ‘classical’ apoptosis triggering pathway. Cytoplasmic release of cytochrome c (cyt c ), a mitochondrial electron transporter, is a prominent indicator of such critical step. Therefore, visualizing cyt c efflux in living cells is a convenient approach to address apoptosis triggering and monitor performance...
View article titled, Live-cell visualization of <span class="search-highlight">cytochrome</span> <span class="search-highlight">c</span> : a tool to explore apoptosis
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Articles

Explorations of time and electrochemical potential: opportunities for fresh perspectives on signalling proteins

Julea N. Butt
Journal: Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (1): 47–51.
https://doi.org/10.1042/BST20130256
Published: 23 January 2014
... of a cell to apoptosis. However, once downstream events have resulted in the release of cytochrome c to the cytosol, it is widely considered that cell death is inevitable. Cytochrome c may promote its own release from mitochondria through interactions with the mitochondrial phospholipid cardiolipin...
View article titled, Explorations of time and electrochemical potential: opportunities for fresh perspectives on signalling proteins
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Articles

Platelet mitochondrial function: from regulation of thrombosis to biomarker of disease

Sergey Zharikov, Sruti Shiva
Journal: Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 118–123.
https://doi.org/10.1042/BST20120327
Published: 29 January 2013
... 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 cybrid cytochrome c redox signalling platelet mitochondria The traditional view of the mitochondrion as the ‘powerhouse’ of the cell has greatly evolved over the last few decades. It is now clear...
View article titled, Platelet mitochondrial function: from regulation of thrombosis to biomarker of disease
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Articles

Advances in TERS (tip-enhanced Raman scattering) for biochemical applications

Regina Treffer, René Böhme, Tanja Deckert-Gaudig, Katherine Lau, Stephan Tiede, Xiumei Lin, Volker Deckert
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 609–614.
https://doi.org/10.1042/BST20120033
Published: 20 July 2012
... will be highlighted here. On the one hand, TERS measurements on a single mitochondrion are discussed, monitoring the oxidation state of the central iron ion of cytochrome c , leading towards a single protein characterization scheme in a natural environment. On the other hand, a novel approach of single molecule...
View article titled, Advances in TERS (tip-enhanced Raman scattering) for biochemical applications
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Articles

Exploring the biochemistry at the extracellular redox frontier of bacterial mineral Fe(III) respiration

David J. Richardson, Marcus J. Edwards, Gaye F. White, Nanakow Baiden, Robert S. Hartshorne, Jim Fredrickson, Liang Shi, John Zachara, Andrew J. Gates, Julea N. Butt, Thomas A. Clarke
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (3): 493–500.
https://doi.org/10.1042/BST20120018
Published: 22 May 2012
... To whom correspondence should be addressed (email d.richardson@uea.ac.uk ). 20 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cytochrome c electron paramagnetic resonance (EPR) electron transfer iron respiration protein film voltammetry Shewanella...
View article titled, Exploring the biochemistry at the extracellular redox frontier of bacterial mineral Fe(III) respiration
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Articles

Dynamics in transient complexes of redox proteins

Marcellus Ubbink
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (2): 415–418.
https://doi.org/10.1042/BST20110698
Published: 21 March 2012
.... These proteins catalyse the transport of electrons from one redox enzyme to another. Well-known examples are Cc (cytochrome c ) and plastocyanin, which shuttle electrons in the respiratory and photosynthetic redox chains respectively. The electron flux through these chains is high, to maximize energy conversion...
View article titled, Dynamics in transient complexes of redox proteins
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Articles

Spectroscopic analysis of protein Fe–NO complexes

César Bellota-Antón, John Munnoch, Kirsty Robb, Katrin Adamczyk, Marco Candelaresi, Anthony W. Parker, Ray Dixon, Matthew I. Hutchings, Neil T. Hunt, Nicholas P. Tucker
Journal: Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1293–1298.
https://doi.org/10.1042/BST0391293
Published: 21 September 2011
... biochemical, molecular and spectroscopic methods. Recently, we have applied ultrafast 2D-IR (two-dimensional IR) spectroscopy to the analysis of NO–protein interactions using Mb (myoglobin) and Cc (cytochrome c ) as model haem proteins. The ultrafast fluctuations of Cc and Mb show marked differences...
View article titled, Spectroscopic analysis of protein Fe–NO complexes
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Articles

Achievements and perspectives in yeast acetic acid-induced programmed cell death pathways

Nicoletta Guaragnella, Lucia Antonacci, Salvatore Passarella, Ersilia Marra, Sergio Giannattasio
Journal: Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1538–1543.
https://doi.org/10.1042/BST0391538
Published: 21 September 2011
... achievements in the elucidation of the events leading to PCD that occur as a response to yeast treatment with AA (acetic acid). In particular, ROS (reactive oxygen species) generation, cyt c (cytochrome c ) release and mitochondrial function and proteolytic activity will be dealt with as they vary along the AA...
View article titled, Achievements and perspectives in yeast acetic acid-induced programmed cell death pathways
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Articles

Avoidance of the cytochrome c biogenesis system by periplasmic CXXCH motifs

Despoina A.I. Mavridou, Martin Braun, Linda Thöny-Meyer, Julie M. Stevens, Stuart J. Ferguson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1124–1128.
https://doi.org/10.1042/BST0361124
Published: 19 November 2008
...Despoina A.I. Mavridou; Martin Braun; Linda Thöny-Meyer; Julie M. Stevens; Stuart J. Ferguson The CXXCH motif is usually recognized in the bacterial periplasm as a haem attachment site in apocytochromes c . There is evidence that the Escherichia coli Ccm (cytochrome c maturation) system recognizes...
View article titled, Avoidance of the <span class="search-highlight">cytochrome</span> <span class="search-highlight">c</span> biogenesis system by periplasmic CXXCH motifs
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Articles

A structural analysis of the transient interaction between the cytochrome bc 1 complex and its substrate cytochrome c

Ajeeta Nyola, Carola Hunte
Journal: Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 981–985.
https://doi.org/10.1042/BST0360981
Published: 19 September 2008
...Ajeeta Nyola; Carola Hunte In cellular respiration, cytochrome c transfers electrons from the cytochrome bc 1 complex to cytochrome c oxidase by transiently binding to the membrane proteins. The first X-ray structure of the yeast cytochrome bc 1 complex with bound cytochrome c revealed the general...
View article titled, A structural analysis of the transient interaction between the cytochrome bc 1 complex and its substrate <span class="search-highlight">cytochrome</span> <span class="search-highlight">c</span>
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Articles

Mitochondrial translocation of p53 underlies the selective death of hippocampal CA1 neurons after global cerebral ischaemia

H. Endo, A. Saito, P.H. Chan
Journal: Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1283–1286.
https://doi.org/10.1042/BST0341283
Published: 25 October 2006
... permeabilization of the outer mitochondrial membrane by forming an inhibitory complex with a protective Bcl-2 family protein, resulting in cytochrome c release in several cell line systems. However, it is unclear how the mitochondrial p53 pathway mediates neuronal apoptosis after cerebral ischaemia. We examined...
View article titled, Mitochondrial translocation of p53 underlies the selective death of hippocampal CA1 neurons after global cerebral ischaemia
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Articles

Targeting Bid to prevent programmed cell death in neurons

C. Culmsee, N. Plesnila
Journal: Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1334–1340.
https://doi.org/10.1042/BST0341334
Published: 25 October 2006
... programmed cell death is prominent. 1 To whom correspondence should be addressed (email carsten.culmsee@cup.uni-muenchen.de ). 19 7 2006 © 2006 The Biochemical Society 2006 apoptosis inducing factor (AIF) Bid caspase cytochrome c mitochondrion programmed cell death...
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Articles

Biochemical analysis of mutations in P450 oxidoreductase

A.V. Pandey
Journal: Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1186–1191.
https://doi.org/10.1042/BST0341186
Published: 25 October 2006
... or variant POR and characterized their activities with cytochrome c and P450c17 assays. We have recently completed an extensive study of the range of POR mutations and characterized the mutants/polymorphisms A112V, T139A, M260V, Y456H, A500V, G536R, L562P, R613X, V628I and F643del from sequencing of patient...
View article titled, Biochemical analysis of mutations in P450 oxidoreductase
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Articles

Comparison of the structural and kinetic properties of the cytochrome c nitrite reductases from Escherichia coli , Wolinella succinogenes , Sulfurospirillum deleyianum and Desulfovibrio desulfuricans

T.A. Clarke, A.M. Hemmings, B. Burlat, J.N. Butt, J.A. Cole, D.J. Richardson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (1): 143–145.
https://doi.org/10.1042/BST0340143
Published: 20 January 2006
... The Biochemical Society 2006 active-site channel cytochrome c nitrite reductase NrfA sequence alignment structural alignment The periplasmic cytochrome c nitrite reductase, NrfA, catalyses the 6e − reduction of NO 2 − to NH 4 + during anaerobic respiration in many Gram-negative...
View article titled, Comparison of the structural and kinetic properties of the <span class="search-highlight">cytochrome</span> <span class="search-highlight">c</span> nitrite reductases from Escherichia coli , Wolinella succinogenes , Sulfurospirillum deleyianum and Desulfovibrio desulfuricans
Open the PDF for Comparison of the structural and kinetic properties of the <span class="search-highlight">cytochrome</span> <span class="search-highlight">c</span> nitrite reductases from Escherichia coli , Wolinella succinogenes , Sulfurospirillum deleyianum and Desulfovibrio desulfuricans in another window
Articles

Is a third proton-conducting pathway operative in bacterial cytochrome c oxidase?

J. Salje, B. Ludwig, O.-M.H. Richter
Journal: Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (4): 829–831.
https://doi.org/10.1042/BST0330829
Published: 01 August 2005
...J. Salje; B. Ludwig; O.-M.H. Richter Despite the existence of several three-dimensional structures of cytochrome c oxidases, a detailed understanding of pathways involved in proton movements through the complex remains largely elusive. Next to the two well-established pathways (termed D and K...
View article titled, Is a third proton-conducting pathway operative in bacterial <span class="search-highlight">cytochrome</span> <span class="search-highlight">c</span> oxidase?
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Articles

Covalent cofactor attachment to proteins: cytochrome c biogenesis

J.M. Stevens, T. Uchida, O. Daltrop, S.J. Ferguson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (4): 792–795.
https://doi.org/10.1042/BST0330792
Published: 01 August 2005
... and in vivo studies have provided insight into the function of this protein and into the overall process of cytochrome c biogenesis. © 2005 The Biochemical Society 2005 CcmE chaperone cofactor covalent bond cytochrome c haem 1 To whom correspondence should be addressed (email...
View article titled, Covalent cofactor attachment to proteins: <span class="search-highlight">cytochrome</span> <span class="search-highlight">c</span> biogenesis
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Articles

Is COX-2 a ‘collateral’ target in cancer prevention?

K. Kashfi, B. Rigas
Journal: Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (4): 724–727.
https://doi.org/10.1042/BST0330724
Published: 01 August 2005
... Society 2005 apoptosis carbonic anhydrase cell cycle coxib cytochrome c NAG-1 (non-steroidal anti-inflammatory drug-activated gene) Cancer prevention, at present a better option than cancer treatment, is entering an era when it appears to be a realistic possibility. The seminal...
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Articles

The role of ResA in type II cytochrome c maturation

A. Crow, N.E. Le Brun, A. Oubrie
Journal: Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (1): 149–151.
https://doi.org/10.1042/BST0330149
Published: 01 February 2005
... cytochrome c maturation in Bacillus subtilis with particular emphasis on the crystal structures of ResA. Because of the intimate nature of the thiol–disulphide redox chemistry (which involves the formation of a transient disulphide bond between redox partners) and short distance between the cleft...
View article titled, The role of ResA in type II <span class="search-highlight">cytochrome</span> <span class="search-highlight">c</span> maturation
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Articles

Cytochrome c nitrite reductase: from structural to physicochemical analysis

B. Burlat, J.D. Gwyer, S. Poock, T. Clarke, J.A. Cole, A.M. Hemmings, M.R. Cheesman, J.N. Butt, D.J. Richardson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (1): 137–140.
https://doi.org/10.1042/BST0330137
Published: 01 February 2005
... and Technical Research) Office and the ESF (European Science Foundation). cytochrome c haem magnetic CD (MCD) nitrite reductase oxidoreductase protein-film voltammetry (PFV) MCD spectra have been reported for oxidized NrfA from two sources [ 4 , 10 ]. Spectra of E. coli NrfA...
View article titled, <span class="search-highlight">Cytochrome</span> <span class="search-highlight">c</span> nitrite reductase: from structural to physicochemical analysis
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Articles

Study of prostaglandin receptors in mitochondria on apoptosis of human lung carcinoma cell line A549

K.M. Fang, W.H. Shu, H.C. Chang, J.J. Wang, O.T. Mak
Journal: Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (6): 1078–1080.
https://doi.org/10.1042/BST0321078
Published: 26 October 2004
... in cell and mitochondrial membrane. 1 To whom correspondence should be addressed (email paul@mail.ncku.edu.tw ). 23 7 2004 © 2004 The Biochemical Society 2004 apoptosis cyclo-oxygenase cytochrome c mitochondrion prostaglandin receptor Research Colloquia: Research...
View article titled, Study of prostaglandin receptors in mitochondria on apoptosis of human lung carcinoma cell line A549
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Articles

Cytochrome c, an ideal antioxidant

M.O. Pereverzev, T.V. Vygodina, A.A. Konstantinov, V.P. Skulachev
Journal: Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1312–1315.
https://doi.org/10.1042/bst0311312
Published: 01 December 2003
...M.O. Pereverzev; T.V. Vygodina; A.A. Konstantinov; V.P. Skulachev Generation of Δψ (membrane potential) by cytochrome oxidase proteoliposomes oxidizing superoxide-reduced cytochrome c has been demonstrated. XO+HX (xanthine oxidase and hypoxanthine) were used to produce superoxide. It was found...
View article titled, <span class="search-highlight">Cytochrome</span> <span class="search-highlight">c</span>, an ideal antioxidant
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Articles

Calmodulin-dependent regulation of mammalian nitric oxide synthase

S. Daff
Journal: Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (3): 502–505.
https://doi.org/10.1042/bst0310502
Published: 01 June 2003
...; the resultant domain mobility leads to activation. autoinhibition calmodulin cytochrome c electron transfer nitric oxide reductase domain Abbreviations used: NOS, nitric oxide synthase; nNOS, iNOS, eNOS, neuronal, induced and endothelial NOS respectively; nNOSrd, nNOS reductase domain...
View article titled, Calmodulin-dependent regulation of mammalian nitric oxide synthase
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Articles

Novel domain packing in the crystal structure of a thiosulphate-oxidizing enzyme

V. A. Bamford, B. C. Berks, A. M. Hemmings
Journal: Biochemical Society Transactions
Biochem Soc Trans (2002) 30 (4): 638–642.
https://doi.org/10.1042/bst0300638
Published: 01 August 2002
... haemoproteins where both partners adopt the c -type cytochrome fold. The packing of c -type cytochrome domains both within SoxA and at the interface between the subunits of the complex has been compared with other examples and found to be unique. cytochrome c electron transfer SoxAX complex 2...
View article titled, Novel domain packing in the crystal structure of a thiosulphate-oxidizing enzyme
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Articles

GSH extrusion and the mitochondrial pathway of apoptotic signalling

S. Coppola, L. Ghibelli
Journal: Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (2): 56–61.
https://doi.org/10.1042/bst0280056
Published: 01 February 2000
... is required for the damage-induced mitochondrial pathway. This is suggested by the finding that the depletion of glutathione, a common event in damage-induced apoptosis, is necessary and sufficient to induce cytochrome c release, the key event of this pathway. A model is proposed with GSH efflux...
View article titled, GSH extrusion and the mitochondrial pathway of apoptotic signalling
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Articles

Function of the mitochondrial outer membrane as a diffusion barrier in health and diseases

F. N. Gellerich, S. Trumbeckaite, J. R. Opalka, E. Seppet, H. N. Rasmussen, C. Neuhoff, S. Zierz
Journal: Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (2): 164–169.
https://doi.org/10.1042/bst0280164
Published: 01 February 2000
... as a prerequisite for the action of ADP shuttles via creatine kinases or adenylate kinases. If the outer membrane becomes leaky, cytochrome c and apoptosis-inducing factor can be released, leading to apoptosis, and as a bioenergetic consequence the cytosolic phosphorylation potential decreases. Leaky outer...
View article titled, Function of the mitochondrial outer membrane as a diffusion barrier in health and diseases
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Articles

Mitochondria and cell death

A. P. Halestrap, E. Doran, J. P. Gillespie, A. O'Toole
Journal: Biochemical Society Transactions
Biochem Soc Trans (2000) 28 (2): 170–177.
https://doi.org/10.1042/bst0280170
Published: 01 February 2000
... MPTP opening directly. Recovery of hearts correlates with subsequent closure, and agents that prevent opening or enhance closure protect from injury. Transient MPTP opening may also be involved in apoptosis by initially causing swelling and rupture of the outer membrane to release cytochrome c (cyt c...
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