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Keywords: cystic fibrosis
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Biochem Soc Trans (2020) 48 (5): 2347–2357.
Published: 20 October 2020
... ) 12 8 2020 21 9 2020 22 9 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 asthma chronic obstructive pulmonary disease cilia cystic fibrosis mucus Xenopus As we breathe, we inhale particles, toxins...
Biochem Soc Trans (2018) 46 (3): 619–630.
Published: 09 May 2018
... based on their size or function. Two of the more well-known and widely studied ncRNA species are microRNAs (miRNAs) and lncRNAs. These are regulatory RNAs and their altered expression has been implicated in the pathogenesis of a variety of human diseases. Failure to express a functional cystic fibrosis...
Biochem Soc Trans (2015) 43 (5): 975–982.
Published: 09 October 2015
...Samuel J. Bose; Toby S. Scott-Ward; Zhiwei Cai; David N. Sheppard The anion channel cystic fibrosis transmembrane conductance regulator (CFTR) is a unique ATP-binding cassette (ABC) transporter. CFTR plays a pivotal role in transepithelial ion transport as its dysfunction in the genetic disease...
Includes: Supplementary data
Biochem Soc Trans (2011) 39 (4): 1023–1027.
Published: 20 July 2011
... in nasal polyp epithelial cells in air/liquid interface cultures has also been reported [ 18 ]. Expression of SPLUNC1 has been determined in a number of inflammatory and/or infectious disorders. In end-stage CF (cystic fibrosis), expression was significantly elevated in diseased airways, but was not co...
Biochem Soc Trans (2011) 39 (4): 1045–1050.
Published: 20 July 2011
... defence molecules such as BPI, are of exceptional relevance. In the present review, we highlight possible functions of BPI during acute pneumonia and CF (cystic fibrosis)-associated chronic infections in the lung. 1 To whom correspondence should be addressed (email andre.gessner@klinik.uni...
Biochem Soc Trans (2010) 38 (2): 695–701.
Published: 22 March 2010
... review, we discuss a plausible use of genistein in treatment of two genetic disorders: CF (cystic fibrosis) and MPS (mucopolysaccharidosis). Although various biological actions of genistein are employed in these two cases, in vitro studies, tests on animal models and pilot clinical trials suggest...
Biochem Soc Trans (2009) 37 (4): 863–867.
Published: 22 July 2009
...Paul J. Buchanan; Robert K. Ernst; J. Stuart Elborn; Bettina Schock CF (cystic fibrosis) is a severe autosomal recessive disease most common in Northwest European populations. Underlying mutations in the CFTR (CF transmembrane conductance regulator) gene cause deregulation of ion transport...
Biochem Soc Trans (2003) 31 (4): 770–773.
Published: 01 August 2003
... subjects with MBL deficiency remain healthy. MBL deficiency is also associated with non-infectious diseases including systemic lupus erythematosus, rheumatoid arthritis, cystic fibrosis and common variable immunodeficiency. MBL deficiency may affect susceptibility to (e.g. meningococcal disease), or alter...