... cell epithelial cells [ 9 ]. In 1999, Hinz et al. [ 7 ] demonstrated that NF-κB can promote G 1 /S transition in both carcinoma cells and mouse embryonic fibroblasts, an effect typically dependent on regulation of cyclin D1 expression [ 7 ]. Direct NF-κB-dependent regulation of cyclin D1 was later...

...Ini-Isabée Witzel; Li Fang Koh; Neil D. Perkins Cyclin D1 is a key regulator of cell proliferation and its expression is subject to both transcriptional and post-transcriptional regulation. In different cellular contexts, different pathways assume a dominant role in regulating its expression...