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Biochem Soc Trans (2013) 41 (4): 1008–1016.
Published: 18 July 2013
...Jane A. Endicott; Martin E.M. Noble Structural studies of members of the CDK (cyclin-dependent protein kinase) family have made a significant contribution to our understanding of the regulation of protein kinases. The structure of monomeric unphosphorylated CDK2 was the first of an inactive protein...
Biochem Soc Trans (2010) 38 (1): 72–77.
Published: 19 January 2010
...Wouter van Zon; Rob M.F. Wolthuis Active cyclin B1–Cdk1 (cyclin-dependent kinase 1) keeps cells in mitosis, allowing time for spindle microtubules to capture the chromosomes and for incorrect chromosome-spindle attachments to be repaired. Meanwhile, securin, an inhibitor of separase, secures...
Biochem Soc Trans (2007) 35 (1): 7–11.
Published: 22 January 2007
... involved with the cell cycle, including cyclins and cyclin-dependent kinases. We solved the structure of the enzyme in each of its two states, the unphosphorylated glycogen phosphorylase b (GPb) and the phosphorylated glycogen phosphorylase a (GPa), and showed that there was a significant...
Biochem Soc Trans (2003) 31 (2): 366–370.
Published: 01 April 2003
...S.M. Oredsson The driving force of the cell cycle is the activities of cyclin-dependent kinases (CDKs). Key steps in the regulation of the cell cycle therefore must impinge upon the activities of the CDKs. CDKs exert their functions when bound to cyclins that are expressed cyclically during...