...Jane A. Endicott; Martin E.M. Noble Structural studies of members of the CDK (cyclin-dependent protein kinase) family have made a significant contribution to our understanding of the regulation of protein kinases. The structure of monomeric unphosphorylated CDK2 was the first of an inactive protein...

...Wouter van Zon; Rob M.F. Wolthuis Active cyclin B1–Cdk1 (cyclin-dependent kinase 1) keeps cells in mitosis, allowing time for spindle microtubules to capture the chromosomes and for incorrect chromosome-spindle attachments to be repaired. Meanwhile, securin, an inhibitor of separase, secures...

... involved with the cell cycle, including cyclins and cyclin-dependent kinases. Most protein kinases are switched on in response to a cellular signal. They catalyse the transfer of the γ-phosphate from ATP to a serine, threonine or tyrosine hydroxy group in the target protein. The change from a non...

...S.M. Oredsson The driving force of the cell cycle is the activities of cyclin-dependent kinases (CDKs). Key steps in the regulation of the cell cycle therefore must impinge upon the activities of the CDKs. CDKs exert their functions when bound to cyclins that are expressed cyclically during...