... are not expressed in the mouse heart and could possibly form the basis for the differing phenotype in the rodent heart [ 52 ]. cardiac arrhythmia cyclic nucleotide intracellular signaling muscular dystrophy Popeye domain-containing protein–protein interaction The cyclic nucleotide 3′,5′-cyclic...

...M.J. Cann Cyclic nucleotide PDEs (phosphodiesterases) regulate cellular levels of cAMP and cGMP by controlling the rate of degradation. Several mammalian PDE isoforms possess N-terminal GAF (found in cGMP PDEs, Anabaena adenylate cyclases and Escherichia coli FhlA; where FhlA is formate hydrogen...