... a transformative agreement with Individual. cannabinoids cryo-electron microscopy crystallography G-protein-coupled receptors Human endocannabinoid signaling is primarily mediated by the class A G protein-coupled receptors (GPCRs) CB1 and CB2. Class A GPCRs consist of an extracellular N-terminal...

... of Medicine in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society. cryo-electron microscopy crystallography kinesin microtubule molecular motors tubulin Kinesins are a superfamily of motor proteins that drive a variety of essential cell...

... of knowledge of protein–protein and protein–lipid interactions governing the apoptotic function of BAK and BAX, as determined through X-ray crystallography and NMR spectroscopy studies. BAK and BAX are dormant, globular α-helical proteins that participate in protein–protein interactions with other pro-death...

... inhibitors bound in cyt bc complexes resolved by X-ray crystallography and cryo-EM structures. Although the Q i site architecture of cyt bc 1 complex and cyt bcc complex differs considerably, quinone molecules were resolved at the respective Q i sites in very similar distance to haem b H . In contrast, more...

... in the structural biology of GPCRs as currently only about one quarter of human non-odorant receptors have had their structure determined. Initially, all the structures were determined by X-ray crystallography, but recent advances in electron cryo-microscopy (cryo-EM) now make GPCRs tractable targets for single...

... biology toolbox. Considered as one of the pillars of structural biology, X-ray crystallography has been the most successful method for solving three-dimensional protein structures at atomic level to date. It is however limited by the success in obtaining well-ordered protein crystals that diffract at high...

... was initially determined by NMR, revealing an immunoglobulin-like fold and the location of the putative lipid-binding site [ 44 ] ( Figure 3B ). The site was subsequently confirmed by X-ray crystallography, as well as the involvement of WIF epidermal growth factor-like domains in binding glycosaminoglycans [ 45...

... for high-throughput screenings. Correspondence: Atsuko Yamashita ( a_yama@okayama-u.ac.jp ) X-ray crystallography has been essential to the determination of the atomic structure of proteins for more than 60 years. Even with recent advances in cryo-electron microscopy (cryo-EM) [ 1...

... for glycan complexes [ 23 , 24 ] are numerated. Correspondence: María T. Elola ( mt_elola@yahoo.com ) 24 3 2020 25 5 2020 8 6 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cell binding crystallography...

... and activity. Correspondence: Wei Li ( wl225@cam.ac.uk ) 2 4 2019 30 4 2019 2 5 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 BMP:receptor interaction bone morphogenetic protein 9 crystallography endothelial cells...

... 2019 crystallography fibrinolysis protease inhibitor Plasminogen (Plg) is the zymogen form of the serine protease plasmin (Plm) which is well known for its fibrinolytic function ( Figure 1 ) together with many other indispensable roles such as cell migration [ 1 ], wound healing [ 2 , 3...

...) and the regulation of Myc protein turnover. The development of inhibitors that block the interaction of Myc with chromatin, and its subsequent recruitment of the transcriptional regulatory apparatus, is a major avenue of current investigation [ 12 , 19 , 20 ]. aurora kinases crystallography intrinsically...

.... difficile , C. tetani , and C. botulinum . Correspondence: Eric J. Sundberg ( esundberg@ihv.umaryland.edu ) 2 8 2016 27 9 2016 29 9 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 crystallography Gram-positive...

... for therapeutic application. 1 email marmor@wistar.upenn.edu 28 6 2004 © 2004 The Biochemical Society 2004 chromatin regulation crystallography enzymology histone deacetylase NAD + silent information regulator-2 (Sir2) The enzymes that mediate post-translational...

... crystallography inhibitor matrix metalloprotease (MMP) optimization selectivity structure Abbreviation used: MMP, matrix metalloprotease. Design of Inhibitors for Proteolytic Cascades 17 Matrix metalloprotease inhibitors: design from structure N. Borkakoti1 Chemical Technologies, Roche Products...

...-erythritol (CDP-ME) and Key words: cytidylyltranferase, enzyme, manganese, synthase, X-ray crystallography, zinc. Abbreviations used: IPP, isopentenyl pyrophosphate; DMAPP, dimethylallyl pyrophosphate; DOXP, 1-deoxy-d-xylulose 5-phosphate; MEP, 2C-methyl-d-erythritol 4-phosphate; CDP-ME, 4- diphosphocytidyl...

.... The structures of the Arabidopsis thaliana KAS family are compared. 26 6 2000 1 To whom correspondence should be addressed (e-mail knowles@biobase.dk ) © 2000 Biochemical Society 2000 Claisen condensation crystallography fatty acid synthase in vitro mutagenesis thiolase fold...