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Keywords: crystallography
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Articles
Biochem Soc Trans (2022) 50 (3): 1091–1103.
Published: 06 May 2022
... of knowledge of protein–protein and protein–lipid interactions governing the apoptotic function of BAK and BAX, as determined through X-ray crystallography and NMR spectroscopy studies. BAK and BAX are dormant, globular α-helical proteins that participate in protein–protein interactions with other pro-death...
Includes: Supplementary data
Articles
Biochem Soc Trans (2022) 50 (2): 877–893.
Published: 31 March 2022
... inhibitors bound in cyt bc complexes resolved by X-ray crystallography and cryo-EM structures. Although the Q i site architecture of cyt bc 1 complex and cyt bcc complex differs considerably, quinone molecules were resolved at the respective Q i sites in very similar distance to haem b H . In contrast, more...
Articles
Biochem Soc Trans (2021) 49 (5): 2345–2355.
Published: 28 September 2021
... in the structural biology of GPCRs as currently only about one quarter of human non-odorant receptors have had their structure determined. Initially, all the structures were determined by X-ray crystallography, but recent advances in electron cryo-microscopy (cryo-EM) now make GPCRs tractable targets for single...
Articles
Biochem Soc Trans (2020) 48 (6): 2505–2524.
Published: 10 November 2020
... biology toolbox. Considered as one of the pillars of structural biology, X-ray crystallography has been the most successful method for solving three-dimensional protein structures at atomic level to date. It is however limited by the success in obtaining well-ordered protein crystals that diffract at high...
Articles
Biochem Soc Trans (2020) 48 (4): 1765–1780.
Published: 29 July 2020
... with Portland Press and the Biochemical Society under a transformative agreement with JISC. beta-catenin cancer crystallography frizzled glycogen synthase kinase Wnt proteins Wnt signalling involves a series of complex pathways and underpins developmental processes [ 1 ]. When dysregulated...
Articles
Biochem Soc Trans (2020) 48 (4): 1661–1673.
Published: 17 July 2020
... Press Limited on behalf of the Biochemical Society 2020 binder proteins crystallography high-throughput screening recombinant proteins X-ray crystallography has been essential to the determination of the atomic structure of proteins for more than 60 years. Even with recent advances...
Articles
Biochem Soc Trans (2020) 48 (3): 1255–1268.
Published: 29 June 2020
... Limited on behalf of the Biochemical Society 2020 cell binding crystallography galectin-8 glycan array glycan specificity sialylation The galectin family is a group of evolutionary-conserved soluble lectins characterized by their ability to recognize β-galactosides through...
Includes: Supplementary data
Articles
Biochem Soc Trans (2019) 47 (3): 779–791.
Published: 24 May 2019
... interaction bone morphogenetic protein 9 crystallography endothelial cells ligand competition pulmonary arterial hypertension In summary, human genetics studies support a central role of compromised BMP9 signalling in PAH and HHT, and preclinical studies suggest the beneficial effects...
Articles
Biochem Soc Trans (2019) 47 (2): 541–557.
Published: 05 March 2019
... 10 2018 28 1 2019 31 1 2019 crystallography fibrinolysis protease inhibitor Plasminogen (Plg) is the zymogen form of the serine protease plasmin (Plm) which is well known for its fibrinolytic function ( Figure 1 ) together with many other indispensable roles such as cell...
Includes: Supplementary data
Articles
Biochem Soc Trans (2017) 45 (3): 709–717.
Published: 15 June 2017
..., suggesting that Aurora-A must act through a kinase-independent mechanism. Certain Aurora-A inhibitors, such as MLN8237/alisertib and CD532, can destabilize N-Myc or c-Myc by disrupting the complex, while other Aurora-A inhibitors have little effect [ 42 – 44 ]. aurora kinases crystallography...
Articles
Biochem Soc Trans (2016) 44 (6): 1659–1666.
Published: 02 December 2016
... on behalf of the Biochemical Society 2016 crystallography Gram-positive bacteria type IV pili Pili or fimbriae are hair-like appendages present on the surface of bacterial cells. They are universally oligomeric fibers composed of protein subunits called pilins. They can be assembled...
Articles
Biochem Soc Trans (2004) 32 (6): 904–909.
Published: 26 October 2004
... to play dynamic roles in NAD + association and protein catalysis. chromatin regulation crystallography enzymology histone deacetylase NAD + silent information regulator-2 (Sir2) The enzymes that mediate post-translational modification of the N-terminal tails of the histone proteins...
Articles
Biochem Soc Trans (2004) 32 (1): 17–20.
Published: 01 February 2004
... crystallography inhibitor matrix metalloprotease (MMP) optimization selectivity structure Abbreviation used: MMP, matrix metalloprotease. Design of Inhibitors for Proteolytic Cascades 17 Matrix metalloprotease inhibitors: design from structure N. Borkakoti1 Chemical Technologies, Roche Products...
Articles
Biochem Soc Trans (2003) 31 (3): 537–542.
Published: 01 June 2003
...-erythritol (CDP-ME) and Key words: cytidylyltranferase, enzyme, manganese, synthase, X-ray crystallography, zinc. Abbreviations used: IPP, isopentenyl pyrophosphate; DMAPP, dimethylallyl pyrophosphate; DOXP, 1-deoxy-d-xylulose 5-phosphate; MEP, 2C-methyl-d-erythritol 4-phosphate; CDP-ME, 4- diphosphocytidyl...
Articles
Biochem Soc Trans (2000) 28 (6): 601–607.
Published: 01 December 2000
.... The structures of the Arabidopsis thaliana KAS family are compared. 26 6 2000 1 To whom correspondence should be addressed (e-mail knowles@biobase.dk ) © 2000 Biochemical Society 2000 Claisen condensation crystallography fatty acid synthase in vitro mutagenesis thiolase fold...