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Keywords: crystallography
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Articles
Biochem Soc Trans (2023) 51 (4): 1533–1543.
Published: 10 August 2023
... a transformative agreement with Individual. cannabinoids cryo-electron microscopy crystallography G-protein-coupled receptors Human endocannabinoid signaling is primarily mediated by the class A G protein-coupled receptors (GPCRs) CB1 and CB2. Class A GPCRs consist of an extracellular N-terminal...
Articles
Biochem Soc Trans (2023) 51 (4): 1505–1520.
Published: 10 August 2023
... the crystal structures of free kinesin fitted into the lower resolution maps. Fully open motor domain conformations were observed for the first time for kinesin-1 in the Apo state in complex with tubulin by X-ray crystallography [ 17 ] and with microtubules by cryo-EM at improved resolution (5–6 Å) than...
Includes: Supplementary data
Articles
Biochem Soc Trans (2022) 50 (3): 1091–1103.
Published: 06 May 2022
... of knowledge of protein–protein and protein–lipid interactions governing the apoptotic function of BAK and BAX, as determined through X-ray crystallography and NMR spectroscopy studies. BAK and BAX are dormant, globular α-helical proteins that participate in protein–protein interactions with other pro-death...
Includes: Supplementary data
Articles
Biochem Soc Trans (2022) 50 (2): 877–893.
Published: 31 March 2022
... inhibitors bound in cyt bc complexes resolved by X-ray crystallography and cryo-EM structures. Although the Q i site architecture of cyt bc 1 complex and cyt bcc complex differs considerably, quinone molecules were resolved at the respective Q i sites in very similar distance to haem b H . In contrast, more...
Articles
Biochem Soc Trans (2021) 49 (5): 2345–2355.
Published: 28 September 2021
... in the structural biology of GPCRs as currently only about one quarter of human non-odorant receptors have had their structure determined. Initially, all the structures were determined by X-ray crystallography, but recent advances in electron cryo-microscopy (cryo-EM) now make GPCRs tractable targets for single...
Articles
Biochem Soc Trans (2020) 48 (6): 2505–2524.
Published: 10 November 2020
... biology toolbox. Considered as one of the pillars of structural biology, X-ray crystallography has been the most successful method for solving three-dimensional protein structures at atomic level to date. It is however limited by the success in obtaining well-ordered protein crystals that diffract at high...
Articles
Biochem Soc Trans (2020) 48 (4): 1765–1780.
Published: 29 July 2020
... with Portland Press and the Biochemical Society under a transformative agreement with JISC. beta-catenin cancer crystallography frizzled glycogen synthase kinase Wnt proteins Wnt signalling involves a series of complex pathways and underpins developmental processes [ 1 ]. When dysregulated...
Articles
Biochem Soc Trans (2020) 48 (4): 1661–1673.
Published: 17 July 2020
... Press Limited on behalf of the Biochemical Society 2020 binder proteins crystallography high-throughput screening recombinant proteins X-ray crystallography has been essential to the determination of the atomic structure of proteins for more than 60 years. Even with recent advances...
Articles
Biochem Soc Trans (2020) 48 (3): 1255–1268.
Published: 29 June 2020
... Limited on behalf of the Biochemical Society 2020 cell binding crystallography galectin-8 glycan array glycan specificity sialylation The galectin family is a group of evolutionary-conserved soluble lectins characterized by their ability to recognize β-galactosides through...
Includes: Supplementary data
Articles
Articles
Biochem Soc Trans (2019) 47 (2): 541–557.
Published: 05 March 2019
... 2019 crystallography fibrinolysis protease inhibitor Plasminogen (Plg) is the zymogen form of the serine protease plasmin (Plm) which is well known for its fibrinolytic function ( Figure 1 ) together with many other indispensable roles such as cell migration [ 1 ], wound healing [ 2 , 3...
Includes: Supplementary data
Articles
Biochem Soc Trans (2017) 45 (3): 709–717.
Published: 15 June 2017
...) and the regulation of Myc protein turnover. The development of inhibitors that block the interaction of Myc with chromatin, and its subsequent recruitment of the transcriptional regulatory apparatus, is a major avenue of current investigation [ 12 , 19 , 20 ]. aurora kinases crystallography intrinsically...
Articles
Biochem Soc Trans (2016) 44 (6): 1659–1666.
Published: 02 December 2016
.... difficile , C. tetani , and C. botulinum . Correspondence: Eric J. Sundberg ( esundberg@ihv.umaryland.edu ) 2 8 2016 27 9 2016 29 9 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 crystallography Gram-positive...
Articles
Biochem Soc Trans (2004) 32 (6): 904–909.
Published: 26 October 2004
... for therapeutic application. 1 email marmor@wistar.upenn.edu 28 6 2004 © 2004 The Biochemical Society 2004 chromatin regulation crystallography enzymology histone deacetylase NAD + silent information regulator-2 (Sir2) The enzymes that mediate post-translational...
Articles
Biochem Soc Trans (2004) 32 (1): 17–20.
Published: 01 February 2004
... crystallography inhibitor matrix metalloprotease (MMP) optimization selectivity structure Abbreviation used: MMP, matrix metalloprotease. Design of Inhibitors for Proteolytic Cascades 17 Matrix metalloprotease inhibitors: design from structure N. Borkakoti1 Chemical Technologies, Roche Products...
Articles
Biochem Soc Trans (2003) 31 (3): 537–542.
Published: 01 June 2003
...-erythritol (CDP-ME) and Key words: cytidylyltranferase, enzyme, manganese, synthase, X-ray crystallography, zinc. Abbreviations used: IPP, isopentenyl pyrophosphate; DMAPP, dimethylallyl pyrophosphate; DOXP, 1-deoxy-d-xylulose 5-phosphate; MEP, 2C-methyl-d-erythritol 4-phosphate; CDP-ME, 4- diphosphocytidyl...
Articles
Biochem Soc Trans (2000) 28 (6): 601–607.
Published: 01 December 2000
.... The structures of the Arabidopsis thaliana KAS family are compared. 26 6 2000 1 To whom correspondence should be addressed (e-mail knowles@biobase.dk ) © 2000 Biochemical Society 2000 Claisen condensation crystallography fatty acid synthase in vitro mutagenesis thiolase fold...