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Keywords: crystallography
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Biochem Soc Trans (2022) 50 (3): 1091–1103.
Published: 06 May 2022
... of knowledge of protein–protein and protein–lipid interactions governing the apoptotic function of BAK and BAX, as determined through X-ray crystallography and NMR spectroscopy studies. BAK and BAX are dormant, globular α-helical proteins that participate in protein–protein interactions with other pro-death...
Includes: Supplementary data
Biochem Soc Trans (2022) 50 (2): 877–893.
Published: 31 March 2022
... inhibitors bound in cyt bc complexes resolved by X-ray crystallography and cryo-EM structures. Although the Q i site architecture of cyt bc 1 complex and cyt bcc complex differs considerably, quinone molecules were resolved at the respective Q i sites in very similar distance to haem b H . In contrast, more...
Biochem Soc Trans (2021) 49 (5): 2345–2355.
Published: 28 September 2021
... in the structural biology of GPCRs as currently only about one quarter of human non-odorant receptors have had their structure determined. Initially, all the structures were determined by X-ray crystallography, but recent advances in electron cryo-microscopy (cryo-EM) now make GPCRs tractable targets for single...
Biochem Soc Trans (2020) 48 (6): 2505–2524.
Published: 10 November 2020
... biology toolbox. Considered as one of the pillars of structural biology, X-ray crystallography has been the most successful method for solving three-dimensional protein structures at atomic level to date. It is however limited by the success in obtaining well-ordered protein crystals that diffract at high...
Biochem Soc Trans (2020) 48 (4): 1765–1780.
Published: 29 July 2020
... with Portland Press and the Biochemical Society under a transformative agreement with JISC. beta-catenin cancer crystallography frizzled glycogen synthase kinase Wnt proteins Wnt signalling involves a series of complex pathways and underpins developmental processes [ 1 ]. When dysregulated...
Biochem Soc Trans (2020) 48 (4): 1661–1673.
Published: 17 July 2020
... Press Limited on behalf of the Biochemical Society 2020 binder proteins crystallography high-throughput screening recombinant proteins X-ray crystallography has been essential to the determination of the atomic structure of proteins for more than 60 years. Even with recent advances...
Biochem Soc Trans (2020) 48 (3): 1255–1268.
Published: 29 June 2020
... Limited on behalf of the Biochemical Society 2020 cell binding crystallography galectin-8 glycan array glycan specificity sialylation The galectin family is a group of evolutionary-conserved soluble lectins characterized by their ability to recognize β-galactosides through...
Includes: Supplementary data
Biochem Soc Trans (2019) 47 (3): 779–791.
Published: 24 May 2019
... interaction bone morphogenetic protein 9 crystallography endothelial cells ligand competition pulmonary arterial hypertension In summary, human genetics studies support a central role of compromised BMP9 signalling in PAH and HHT, and preclinical studies suggest the beneficial effects...
Biochem Soc Trans (2019) 47 (2): 541–557.
Published: 05 March 2019
... 10 2018 28 1 2019 31 1 2019 crystallography fibrinolysis protease inhibitor Plasminogen (Plg) is the zymogen form of the serine protease plasmin (Plm) which is well known for its fibrinolytic function ( Figure 1 ) together with many other indispensable roles such as cell...
Includes: Supplementary data
Biochem Soc Trans (2017) 45 (3): 709–717.
Published: 15 June 2017
..., suggesting that Aurora-A must act through a kinase-independent mechanism. Certain Aurora-A inhibitors, such as MLN8237/alisertib and CD532, can destabilize N-Myc or c-Myc by disrupting the complex, while other Aurora-A inhibitors have little effect [ 42 – 44 ]. aurora kinases crystallography...
Biochem Soc Trans (2016) 44 (6): 1659–1666.
Published: 02 December 2016
... on behalf of the Biochemical Society 2016 crystallography Gram-positive bacteria type IV pili Pili or fimbriae are hair-like appendages present on the surface of bacterial cells. They are universally oligomeric fibers composed of protein subunits called pilins. They can be assembled...
Biochem Soc Trans (2004) 32 (6): 904–909.
Published: 26 October 2004
... to play dynamic roles in NAD + association and protein catalysis. chromatin regulation crystallography enzymology histone deacetylase NAD + silent information regulator-2 (Sir2) The enzymes that mediate post-translational modification of the N-terminal tails of the histone proteins...
Biochem Soc Trans (2004) 32 (1): 17–20.
Published: 01 February 2004
... crystallography inhibitor matrix metalloprotease (MMP) optimization selectivity structure Abbreviation used: MMP, matrix metalloprotease. Design of Inhibitors for Proteolytic Cascades 17 Matrix metalloprotease inhibitors: design from structure N. Borkakoti1 Chemical Technologies, Roche Products...
Biochem Soc Trans (2003) 31 (3): 537–542.
Published: 01 June 2003
...-erythritol (CDP-ME) and Key words: cytidylyltranferase, enzyme, manganese, synthase, X-ray crystallography, zinc. Abbreviations used: IPP, isopentenyl pyrophosphate; DMAPP, dimethylallyl pyrophosphate; DOXP, 1-deoxy-d-xylulose 5-phosphate; MEP, 2C-methyl-d-erythritol 4-phosphate; CDP-ME, 4- diphosphocytidyl...
Biochem Soc Trans (2000) 28 (6): 601–607.
Published: 01 December 2000
.... The structures of the Arabidopsis thaliana KAS family are compared. 26 6 2000 1 To whom correspondence should be addressed (e-mail knowles@biobase.dk ) © 2000 Biochemical Society 2000 Claisen condensation crystallography fatty acid synthase in vitro mutagenesis thiolase fold...