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Keywords: crystallography
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Articles
Biochem Soc Trans (2023) 51 (4): 1533–1543.
Published: 10 August 2023
... a transformative agreement with Individual. cannabinoids cryo-electron microscopy crystallography G-protein-coupled receptors Human endocannabinoid signaling is primarily mediated by the class A G protein-coupled receptors (GPCRs) CB1 and CB2. Class A GPCRs consist of an extracellular N-terminal...
Articles
Biochem Soc Trans (2023) 51 (4): 1505–1520.
Published: 10 August 2023
... of Medicine in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society. cryo-electron microscopy crystallography kinesin microtubule molecular motors tubulin Kinesins are a superfamily of motor proteins that drive a variety of essential cell...
Includes: Supplementary data
Articles
Biochem Soc Trans (2022) 50 (3): 1091–1103.
Published: 06 May 2022
... of knowledge of protein–protein and protein–lipid interactions governing the apoptotic function of BAK and BAX, as determined through X-ray crystallography and NMR spectroscopy studies. BAK and BAX are dormant, globular α-helical proteins that participate in protein–protein interactions with other pro-death...
Includes: Supplementary data
Articles
Biochem Soc Trans (2022) 50 (2): 877–893.
Published: 31 March 2022
... inhibitors bound in cyt bc complexes resolved by X-ray crystallography and cryo-EM structures. Although the Q i site architecture of cyt bc 1 complex and cyt bcc complex differs considerably, quinone molecules were resolved at the respective Q i sites in very similar distance to haem b H . In contrast, more...
Articles
Biochem Soc Trans (2021) 49 (5): 2345–2355.
Published: 28 September 2021
... in the structural biology of GPCRs as currently only about one quarter of human non-odorant receptors have had their structure determined. Initially, all the structures were determined by X-ray crystallography, but recent advances in electron cryo-microscopy (cryo-EM) now make GPCRs tractable targets for single...
Articles
Biochem Soc Trans (2020) 48 (6): 2505–2524.
Published: 10 November 2020
... biology toolbox. Considered as one of the pillars of structural biology, X-ray crystallography has been the most successful method for solving three-dimensional protein structures at atomic level to date. It is however limited by the success in obtaining well-ordered protein crystals that diffract at high...
Articles
Biochem Soc Trans (2020) 48 (4): 1765–1780.
Published: 29 July 2020
... was initially determined by NMR, revealing an immunoglobulin-like fold and the location of the putative lipid-binding site [ 44 ] ( Figure 3B ). The site was subsequently confirmed by X-ray crystallography, as well as the involvement of WIF epidermal growth factor-like domains in binding glycosaminoglycans [ 45...
Articles
Biochem Soc Trans (2020) 48 (4): 1661–1673.
Published: 17 July 2020
... for high-throughput screenings. Correspondence: Atsuko Yamashita ( a_yama@okayama-u.ac.jp ) X-ray crystallography has been essential to the determination of the atomic structure of proteins for more than 60 years. Even with recent advances in cryo-electron microscopy (cryo-EM) [ 1...
Articles
Biochem Soc Trans (2020) 48 (3): 1255–1268.
Published: 29 June 2020
... for glycan complexes [ 23 , 24 ] are numerated. Correspondence: María T. Elola ( mt_elola@yahoo.com ) 24 3 2020 25 5 2020 8 6 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cell binding crystallography...
Includes: Supplementary data
Articles
Articles
Biochem Soc Trans (2019) 47 (2): 541–557.
Published: 05 March 2019
... 2019 crystallography fibrinolysis protease inhibitor Plasminogen (Plg) is the zymogen form of the serine protease plasmin (Plm) which is well known for its fibrinolytic function ( Figure 1 ) together with many other indispensable roles such as cell migration [ 1 ], wound healing [ 2 , 3...
Includes: Supplementary data
Articles
Biochem Soc Trans (2017) 45 (3): 709–717.
Published: 15 June 2017
...) and the regulation of Myc protein turnover. The development of inhibitors that block the interaction of Myc with chromatin, and its subsequent recruitment of the transcriptional regulatory apparatus, is a major avenue of current investigation [ 12 , 19 , 20 ]. aurora kinases crystallography intrinsically...
Articles
Biochem Soc Trans (2016) 44 (6): 1659–1666.
Published: 02 December 2016
.... difficile , C. tetani , and C. botulinum . Correspondence: Eric J. Sundberg ( esundberg@ihv.umaryland.edu ) 2 8 2016 27 9 2016 29 9 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 crystallography Gram-positive...
Articles
Biochem Soc Trans (2004) 32 (6): 904–909.
Published: 26 October 2004
... for therapeutic application. 1 email marmor@wistar.upenn.edu 28 6 2004 © 2004 The Biochemical Society 2004 chromatin regulation crystallography enzymology histone deacetylase NAD + silent information regulator-2 (Sir2) The enzymes that mediate post-translational...
Articles
Biochem Soc Trans (2004) 32 (1): 17–20.
Published: 01 February 2004
... crystallography inhibitor matrix metalloprotease (MMP) optimization selectivity structure Abbreviation used: MMP, matrix metalloprotease. Design of Inhibitors for Proteolytic Cascades 17 Matrix metalloprotease inhibitors: design from structure N. Borkakoti1 Chemical Technologies, Roche Products...
Articles
Biochem Soc Trans (2003) 31 (3): 537–542.
Published: 01 June 2003
...-erythritol (CDP-ME) and Key words: cytidylyltranferase, enzyme, manganese, synthase, X-ray crystallography, zinc. Abbreviations used: IPP, isopentenyl pyrophosphate; DMAPP, dimethylallyl pyrophosphate; DOXP, 1-deoxy-d-xylulose 5-phosphate; MEP, 2C-methyl-d-erythritol 4-phosphate; CDP-ME, 4- diphosphocytidyl...
Articles
Biochem Soc Trans (2000) 28 (6): 601–607.
Published: 01 December 2000
.... The structures of the Arabidopsis thaliana KAS family are compared. 26 6 2000 1 To whom correspondence should be addressed (e-mail knowles@biobase.dk ) © 2000 Biochemical Society 2000 Claisen condensation crystallography fatty acid synthase in vitro mutagenesis thiolase fold...