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Keywords: cryo-electron microscopy
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Articles
Biochem Soc Trans (2022) 50 (5): 1403–1414.
Published: 05 October 2022
... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cryo-electron microscopy molecular chaperones molecular mechanisms protein conformation All organisms depend on properly folded and functioning proteins...
Articles
Biochem Soc Trans (2022) 50 (1): 569–581.
Published: 25 February 2022
...John W. Vant; Daipayan Sarkar; Jonathan Nguyen; Alexander T. Baker; Josh V. Vermaas; Abhishek Singharoy Single particle analysis cryo-electron microscopy (EM) and molecular dynamics (MD) have been complimentary methods since cryo-EM was first applied to the field of structural biology...
Articles
Biochem Soc Trans (2022) 50 (1): 459–22W.
Published: 07 February 2022
... have been described: contractile tails of Myoviridae -like phages; short non-contractile tails of Podoviridae -like phages; and long and flexible non-contractile tails of Siphoviridae -like phages. While early cryo-electron microscopy (cryo-EM) work elucidated the organisation of the syringe-like...
Articles
Biochem Soc Trans (2021) 49 (6): 2711–2726.
Published: 02 December 2021
... invaluable, the ‘resolution revolution’ of cryo-electron microscopy has transformed our structural investigations, enabling large, dynamic and often transient transcription complexes to be resolved that in many cases had resisted crystallisation. In this review, we highlight the impact cryo-electron...
Articles
Biochem Soc Trans (2021) 49 (6): 2639–2653.
Published: 08 November 2021
... of the Biochemical Society 2021 chromatin cryo-electron microscopy epigenetics eukaryotic gene expression transcription Eukaryotic cells pack their DNA (∼6 billion bases) into the small volume of the nucleus (1 × 10 2 –1 × 10 5  µm 3 ) by organizing their DNA into complex but defined structures...
Articles
Biochem Soc Trans (2021) 49 (5): 2287–2298.
Published: 28 October 2021
...: Robert M. Glaeser ( rmglaeser@lbl.gov ) 6 9 2021 29 9 2021 5 10 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cryo-electron microscopy divide and conquer structure determination Figure 1. Some examples...
Articles
Biochem Soc Trans (2021) 49 (5): 2345–2355.
Published: 28 September 2021
... Laboratory of Molecular Biology in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. cryo-electron microscopy crystallography G-protein-coupled receptors G protein-coupled receptors (GPCRs) are the largest...
Articles
Biochem Soc Trans (2021) 49 (3): 1349–1359.
Published: 10 June 2021
.... cryo-electron microscopy membrane proteins protein complexes protein–lipid interactions SMALP Membrane proteins carry out a wide range of critical functions and are key targets for drug discovery [ 1 ]. However, their location embedded within a lipid bilayer has made them more difficult...
Articles
Biochem Soc Trans (2020) 48 (5): 2261–2272.
Published: 14 October 2020
... biology, but recent advances in cryo-electron microscopy and cryo-electron tomography have further uncovered exciting new snapshots of reconstituted retromer structures. These new structures reveal retromer assembles into an arch-shaped scaffold and suggest the scaffold may be flexible and adaptable...
Articles
Biochem Soc Trans (2020) 48 (3): 1057–1066.
Published: 05 May 2020
... Society under a transformative agreement with JISC. biochemistry cryo-electron microscopy DNA replication in silico reconstitution single molecule Accurate transfer of genetic information from parental to daughter cells requires that chromosome replication is finely tuned, so that DNA...
Articles
Biochem Soc Trans (2019) 47 (1): 37–45.
Published: 15 January 2019
... BY-NC-ND) . AAA proteins cryo-electron microscopy endosomal sorting protein disassembly protein structure E ndosomal S orting C omplex R equired for T ransport (ESCRT) pathways drive membrane fission in numerous cellular processes, including cytokinesis, multivesicular...
Articles
Biochem Soc Trans (2018) 46 (6): 1407–1422.
Published: 12 November 2018
...-resolution structural information that was mostly limited to individual proteins and smaller sub-complexes. Recent developments in the field of cryo-electron microscopy allowed the visualisation of fully assembled yeast and human spliceosomes, providing unprecedented insights into substrate recognition...
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Biochem Soc Trans (2018) 46 (4): 807–816.
Published: 22 June 2018
... 2018 The Author(s) 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cryo-electron microscopy cryo-electron tomography subtomogram averaging...
Articles
Biochem Soc Trans (2017) 45 (6): 1263–1269.
Published: 03 November 2017
... 2017 © 2017 The Author(s) 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cowpea mosaic virus cryo-electron microscopy mutagenesis transient...
Articles
Biochem Soc Trans (2016) 44 (4): 1177–1182.
Published: 15 August 2016
... serves as a resource for structural biologists seeking solutions for difficult structure determination projects. 1 email pcramer@mpibpc.mpg.de 29 3 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 cryo-electron microscopy...
Articles
Biochem Soc Trans (2008) 36 (4): 677–683.
Published: 22 July 2008
...Robert J.C. Gilbert; Ian Brierley; John E.G. McCarthy High-resolution structures have given an extremely detailed view of aspects of ribosomes, including some near-functional states. Here, we review the importance of cryo-electron microscopy, among other techniques, in giving an understanding...
Articles
Biochem Soc Trans (2006) 34 (1): 1–6.
Published: 20 January 2006
... The Biochemical Society 2006 ADP-ribosylation cryo-electron microscopy diphthamide diphtheria toxin elongation factor 2 (EF2) exotoxin A In the elongation cycle of protein synthesis, elongation factor 1A delivers aminoacylated tRNA to the ribosomal A-site, whereafter the peptidyl transferase...