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Keywords: cryo-EM
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Biochem Soc Trans (2023) 51 (4): 1701–1711.
Published: 10 August 2023
...Miles Graham; Peijun Zhang Developments in cryo-electron microscopy (cryo-EM) have been interwoven with the study of viruses ever since its first applications to biological systems. Following the success of single particle cryo-EM in the last decade, cryo-electron tomography (cryo-ET) is now...
Biochem Soc Trans (2023) 51 (3): 1347–1360.
Published: 02 June 2023
... by the technological advancements in cryo-EM analysis, which has elucidated many new P-type ATPase structures and mechanisms and revealed several new ways of regulation. In this review, we highlight the progress of the field and focus on special features that are present in the five subfamilies. Hence, we outline...
Biochem Soc Trans (2023) 51 (1): 427–434.
Published: 25 January 2023
... studies in recent years provide in-depth understanding of how the MLL1 and homologous yeast SET1 complexes interact with the nucleosome core particle (NCP) and how their activities for H3K4 methylation are regulated by the conserved core components. Here, we will discuss the recent single molecule cryo-EM...
Biochem Soc Trans (2022) 50 (6): 1953–1962.
Published: 16 December 2022
... microtubule . Cell 179 , 909 – 22.e12 10.1016/j.cell.2019.09.030 18 Wang , X. , Fu , Y. , Beatty , W.L. , Ma , M. , Brown , A. , Sibley , L.D. et al. ( 2021 ) Cryo-EM structure of cortical microtubules from human parasite Toxoplasma gondii identifies...
Biochem Soc Trans (2022) 50 (6): 1763–1772.
Published: 23 November 2022
... Limited on behalf of the Biochemical Society 2022 cryo-EM membrane proteins palmitoleation WLS Wnt proteins Though sequence similarity between WLS and GPCRs is low (≤ 10%), the Wnt/WLS structures reveal a close resemblance of WLS with the GPCR fold. TM helices 2–8 of WLS align to GPCRs...
Biochem Soc Trans (2022) 50 (1): 231–239.
Published: 22 February 2022
... these, the electron cryomicroscopy (cryo-EM) method microcrystal electron diffraction (MicroED) has produced atomic resolution structures of important biological and small molecules. Since its inception in 2013, MicroED established a demonstrated ability for solving structures of difficult samples using vanishingly...
Biochem Soc Trans (2022) 50 (1): 309–320.
Published: 07 February 2022
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . chromatin CMG cryo-EM Ctf18 Pol epsilon replisome In all replicating systems a hexameric, ring-shaped helicase is loaded around DNA and uses the energy derived from nucleotide hydrolysis to unwind the double helix...
Biochem Soc Trans (2021) 49 (6): 2627–2638.
Published: 23 November 2021
...Joshua A. Lees; Joao M. Dias; Seungil Han Electron cryo-microscopy (cryo-EM) is a powerful technique for the structural characterization of biological macromolecules, enabling high-resolution analysis of targets once inaccessible to structural interrogation. In recent years, pharmaceutical...
Biochem Soc Trans (2021) 49 (5): 1927–1939.
Published: 08 October 2021
... structural advances, as well as highlights how the future structural work will further advance our understanding of this enzyme. Figure 2. Structures of human telomerase holoenzyme determined by electron microscopy. ( A ) 30 Å negative stain EM structure. ( B ) 8 Å cryo-EM structure. ( C ) Sub-4 Å cryo...
Biochem Soc Trans (2019) 47 (1): 399–410.
Published: 07 February 2019
..., Middle and Tail, was published in 1999. Within the last few years, optimization of Mediator purification combined with technical and methodological advances in cryo-electron microscopy (cryo-EM) have revealed unprecedented details of Mediator subunit organization, interactions with RNA polymerase II...
Includes: Supplementary data
In Collection
Biochem Soc Trans (2019) 47 (1): 281–293.
Published: 15 January 2019
... adoption of cryo-EM is the expansion of protein target classes for which structural information can drive project decisions, either through an improved mechanistic understanding of disease biology or through high-quality atomistic experimental models of ligand–protein complexes. Perhaps, the best example...
Biochem Soc Trans (2016) 44 (3): 851–855.
Published: 09 June 2016
... of the rotor. Figure 2 Subunit interactions about the collar region of the V-ATPase in 3 different conformational states Surface representations of collar subunits based on yeast cryo-EM structures for three rotational states [protein data bank (PDB): 3J9T, 3J9U, 3J9V] showing interactions between...
Biochem Soc Trans (2016) 44 (2): 534–540.
Published: 11 April 2016
... implications, with special emphasis on the emerging contributions of cryo-ET. 1 email ruben@biochem.mpg.de 15 1 2016 © 2016 Authors; published by Portland Press Limited 2016 cryo-EM extended-synaptotagmin lipid transfer Orai ryanodine receptor STIM Compartmentalization...