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Keywords: conformational change
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Biochem Soc Trans (2014) 42 (6): 1477–1483.
Published: 17 November 2014
... and temporal dynamics of PKC signalling comes from regulation through various mechanisms, such as phosphorylation, binding to second messengers, conformational changes and binding to scaffolds. Perturbation of any of these mechanisms of control can lead to pathophysiological states. In fact, dysregulation...
Biochem Soc Trans (2013) 41 (5): 1219–1226.
Published: 23 September 2013
... changes of ϵ. The present mini-review summarizes smFRET rotation experiments and previews new smFRET data on the conformational changes of the CTD (C-terminal domain) of ϵ in the E. coli enzyme. 1 Correspondence may be addressed to either author (email michael.boersch@med.uni-jena.de or duncant...
Biochem Soc Trans (2013) 41 (2): 620–624.
Published: 21 March 2013
... conformational change knot mitochondrion molecular dynamics protein translocation In recent years, there has been a surge of interest in the properties and functions of knotted proteins. As more and more knotted structures are deposited in the PDB, it becomes increasingly important to understand how...
Biochem Soc Trans (2013) 41 (1): 205–212.
Published: 29 January 2013
... in the extracellular interhelical space between TM1 and TM7; and (iv) several novel structural water molecules. allosteric regulation conformational change GPCR (G-protein-coupled receptor) molecular dynamics web service The function of GPCRs (G-protein-coupled receptors) is governed...
Biochem Soc Trans (2006) 34 (1): 162–164.
Published: 20 January 2006
... the protein competent to respond to the nitrogen signal conveyed by the signal transduction protein GlnK have also been isolated. Our results suggest that the topological relationship between the central region and the GHKL domain may alter as a consequence of conformational changes induced in response...
Biochem Soc Trans (2004) 32 (5): 721–723.
Published: 26 October 2004
... ligand binding and low-pH ligand release. 1 Correspondence may be addressed to either of these authors (email sblacklow@rics.bwh.harvard.edu or nbeglova@rics.bwh.harvard.edu ). 1 7 2004 © 2004 The Biochemical Society 2004 conformational change interdomain linkers ligand...
Biochem Soc Trans (2003) 31 (3): 631–633.
Published: 01 June 2003
...B.A. Wallace; Robert W. Janes CD spectroscopy is an established and valuable technique for examining protein structure, dynamics and folding. Because of its ability to sensitively detect conformational changes, it has important potential for drug discovery, enabling screening for ligand and drug...
Biochem Soc Trans (2002) 30 (6): 1116–1119.
Published: 01 November 2002
... of the hairpin ribozyme has been established by crystallography, and is well supported by biochemical and biophysical evidence that has identified conformational changes and key nucleotides required for catalysis. Analogous work is under way to establish the active structure of the hammerhead ribozyme...